Expression Levels of Nicotinamide Metabolism-related Protein (NMAP) in Newly Diagnosed Renal Cancer and Non-renal Cancer Populations

NCT ID: NCT04113486

Last Updated: 2020-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-01

Study Completion Date

2022-06-30

Brief Summary

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This study aims to observe the difference between NMAP (nicotinamide metabolism associated protein) serum levels in primary diagnosed renal cancer patients and non-renal cancer patient controls, plot the ROC curve and establish appropriate cut-off values.

Detailed Description

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Conditions

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Carcinoma, Renal Cell

Keywords

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renal cancer tumor biomarker

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Renal cancer group

Patients which imaging studies have found renal mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.

Blood test

Intervention Type OTHER

About 4 ml of blood draw

Urothiasis group

Patients which imaging studies have found renal or ureteral stones, and rule out of renal mass, about 100.

Blood test

Intervention Type OTHER

About 4 ml of blood draw

Renal cysts group

Patients which imaging studies have found renal cysts (simple or complex) about 100.

Blood test

Intervention Type OTHER

About 4 ml of blood draw

Liver cancer group

Patients which imaging studies have found hepatic mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.

Blood test

Intervention Type OTHER

About 4 ml of blood draw

Interventions

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Blood test

About 4 ml of blood draw

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. The tumor group patients were found to have renal or hepatic mass, plan to receive surgical treatment (except for radiofrequency ablation, cryoablation, etc., which were not available for pathological examination). The control group patients were ruled out of tumor based on radiological tests and commonly used tumor biomarkers
2. Age ≥ 18 years old and able to provide written informed consent;
3. Have not received any systemic or topical treatment for kidney/liver tumors.
4. Cardiopulmonary, liver and kidney functions are able to tolerate surgery and can comply with research requirements.

Exclusion Criteria

1. The investigators believe that the subject may be unsuitable for inclusion due to severe concurrent diseases, infections, and etc.
2. The subjects is known or suspected of other malignancies.
3. There has been another history of malignancy in the past 5 years.
4. Major surgery (surgery requiring general anesthesia) was performed within 4 weeks prior to screening visits.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Jie Ding

Attending doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Min NA Shi, MD

Role: CONTACT

Phone: 021-25076143

Email: [email protected]

Facility Contacts

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Jie NA Ding, MD

Role: primary

Other Identifiers

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XHEC-C-2019-104

Identifier Type: -

Identifier Source: org_study_id