Trial Outcomes & Findings for Patient Portal Reminder/Recall for Influenza Vaccination in a Health System- RCT 2 (NCT NCT04110314)

Last Updated: 2022-05-05

Results Overview

Receipt of the annual influenza vaccination (between 10/2/19 - 4/1/20) among index patients. Outcomes will be assessed via vaccine data extraction from the electronic health record and external claims and pharmacy data. Index patients will be randomly selected individuals within an included household, eligible for the following groups (\<18, 18-64 non-diabetic, 65+ non-diabetic, and 18+ diabetic). One index patient per group may be selected from each household. The index patients must also be an active UCLA Health MyChart user (\>= 1 login over the last 12 months from 8/1/19, excluding activity on the user's initial profile activation date). Individuals not affiliated with any primary care practice will be excluded from the primary analysis.

Recruitment status

COMPLETED

Study phase

Target enrollment

430636 participants

Primary outcome timeframe

6 months

Results posted on

2022-05-05

Participant Flow

Participant milestones

Participant milestones
Measure	Gain-framed Portal Reminders + Pre-commitment Prompts Participants receive gain-framed reminder/recall messages regarding influenza vaccination via the patient portal and a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Gain-framed: Patients receive gain-framed reminder/recall messages via the patient portal to get an influenza vaccination. Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	Gain-framed Portal Reminders + No Pre-commitment Prompt Participants receive gain-framed reminder/recall messages regarding influenza vaccination via the patient portal and no pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Gain-framed: Patients receive gain-framed reminder/recall messages via the patient portal to get an influenza vaccination.	Loss-framed Portal Reminders + Pre-commitment Prompt Participants receive loss-framed reminder/recall messages regarding influenza vaccination via the patient portal and a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Loss-framed: Patients receive loss-framed reminder/recall messages via the patient portal to get an influenza vaccination. Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	Loss-framed Portal Reminders + No Pre-commitment Prompt Participants receive loss-framed reminder/recall messages regarding influenza vaccination via the patient portal and a no pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Loss-framed: Patients receive loss-framed reminder/recall messages via the patient portal to get an influenza vaccination.	No Portal Reminder + Pre-commitment Prompt Participants do not receive any reminder/recall messages regarding influenza vaccination via the patient portal but do receive a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	No Portal Reminders + No Pre-commitment Prompt Participants do not receive any reminder/recall messages regarding influenza vaccination via the patient portal and do not receive a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season
Overall Study STARTED	71781	71492	72177	71512	71536	72138
Overall Study Patients Who Met Inclusion	36526	36388	36541	36377	36289	36411
Overall Study COMPLETED	36526	36388	36541	36377	36289	36411
Overall Study NOT COMPLETED	35255	35104	35636	35135	35247	35727

Reasons for withdrawal

Reasons for withdrawal
Measure	Gain-framed Portal Reminders + Pre-commitment Prompts Participants receive gain-framed reminder/recall messages regarding influenza vaccination via the patient portal and a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Gain-framed: Patients receive gain-framed reminder/recall messages via the patient portal to get an influenza vaccination. Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	Gain-framed Portal Reminders + No Pre-commitment Prompt Participants receive gain-framed reminder/recall messages regarding influenza vaccination via the patient portal and no pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Gain-framed: Patients receive gain-framed reminder/recall messages via the patient portal to get an influenza vaccination.	Loss-framed Portal Reminders + Pre-commitment Prompt Participants receive loss-framed reminder/recall messages regarding influenza vaccination via the patient portal and a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Loss-framed: Patients receive loss-framed reminder/recall messages via the patient portal to get an influenza vaccination. Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	Loss-framed Portal Reminders + No Pre-commitment Prompt Participants receive loss-framed reminder/recall messages regarding influenza vaccination via the patient portal and a no pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Loss-framed: Patients receive loss-framed reminder/recall messages via the patient portal to get an influenza vaccination.	No Portal Reminder + Pre-commitment Prompt Participants do not receive any reminder/recall messages regarding influenza vaccination via the patient portal but do receive a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	No Portal Reminders + No Pre-commitment Prompt Participants do not receive any reminder/recall messages regarding influenza vaccination via the patient portal and do not receive a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season
Overall Study Did not meet inclusion criteria	35255	35104	35636	35135	35247	35727

Baseline Characteristics

Patient Portal Reminder/Recall for Influenza Vaccination in a Health System- RCT 2

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Gain-framed Portal Reminders + Pre-commitment Prompts n=36526 Participants Participants receive gain-framed reminder/recall messages regarding influenza vaccination via the patient portal and a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Gain-framed: Patients receive gain-framed reminder/recall messages via the patient portal to get an influenza vaccination. Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	Gain-framed Portal Reminders + No Pre-commitment Prompt n=36388 Participants Participants receive gain-framed reminder/recall messages regarding influenza vaccination via the patient portal and no pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Gain-framed: Patients receive gain-framed reminder/recall messages via the patient portal to get an influenza vaccination.	Loss-framed Portal Reminders + Pre-commitment Prompt n=36541 Participants Participants receive loss-framed reminder/recall messages regarding influenza vaccination via the patient portal and a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Loss-framed: Patients receive loss-framed reminder/recall messages via the patient portal to get an influenza vaccination. Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	Loss-framed Portal Reminders + No Pre-commitment Prompt n=36377 Participants Participants receive loss-framed reminder/recall messages regarding influenza vaccination via the patient portal and a no pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Portal Reminders for Influenza Vaccination: Loss-framed: Patients receive loss-framed reminder/recall messages via the patient portal to get an influenza vaccination.	No Portal Reminder + Pre-commitment Prompt n=36289 Participants Participants do not receive any reminder/recall messages regarding influenza vaccination via the patient portal but do receive a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season Pre-commitment prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination	No Portal Reminders + No Pre-commitment Prompt n=36411 Participants Participants do not receive any reminder/recall messages regarding influenza vaccination via the patient portal and do not receive a pre-commitment prompt asking if they plan to receive the influenza vaccine in the upcoming season	Total n=218532 Participants Total of all reporting groups
Age, Categorical <=18 years	3686 Participants n=5 Participants	3632 Participants n=7 Participants	3727 Participants n=5 Participants	3610 Participants n=4 Participants	3655 Participants n=21 Participants	3736 Participants n=10 Participants	22046 Participants n=115 Participants
Age, Categorical Between 18 and 65 years	26288 Participants n=5 Participants	26191 Participants n=7 Participants	26265 Participants n=5 Participants	26170 Participants n=4 Participants	26180 Participants n=21 Participants	26077 Participants n=10 Participants	157171 Participants n=115 Participants
Age, Categorical >=65 years	6552 Participants n=5 Participants	6565 Participants n=7 Participants	6549 Participants n=5 Participants	6597 Participants n=4 Participants	6454 Participants n=21 Participants	6598 Participants n=10 Participants	39315 Participants n=115 Participants
Sex/Gender, Customized Female Female	21088 Participants n=5 Participants	20881 Participants n=7 Participants	21058 Participants n=5 Participants	21057 Participants n=4 Participants	20947 Participants n=21 Participants	20835 Participants n=10 Participants	125866 Participants n=115 Participants
Sex/Gender, Customized Male	15437 Participants n=5 Participants	15506 Participants n=7 Participants	15482 Participants n=5 Participants	15319 Participants n=4 Participants	15342 Participants n=21 Participants	15575 Participants n=10 Participants	92661 Participants n=115 Participants
Sex/Gender, Customized Other	0 Participants n=5 Participants	0 Participants n=7 Participants	1 Participants n=5 Participants	0 Participants n=4 Participants	0 Participants n=21 Participants	0 Participants n=10 Participants	1 Participants n=115 Participants
Sex/Gender, Customized Unknown	1 Participants n=5 Participants	1 Participants n=7 Participants	0 Participants n=5 Participants	1 Participants n=4 Participants	0 Participants n=21 Participants	1 Participants n=10 Participants	4 Participants n=115 Participants
Race/Ethnicity, Customized White	20096 Participants n=5 Participants	20133 Participants n=7 Participants	20115 Participants n=5 Participants	20056 Participants n=4 Participants	20401 Participants n=21 Participants	20401 Participants n=10 Participants	121202 Participants n=115 Participants
Race/Ethnicity, Customized Black/African American	1674 Participants n=5 Participants	1666 Participants n=7 Participants	1657 Participants n=5 Participants	1649 Participants n=4 Participants	1727 Participants n=21 Participants	1533 Participants n=10 Participants	9906 Participants n=115 Participants
Race/Ethnicity, Customized Asian	3867 Participants n=5 Participants	3789 Participants n=7 Participants	3886 Participants n=5 Participants	3900 Participants n=4 Participants	3715 Participants n=21 Participants	3828 Participants n=10 Participants	22985 Participants n=115 Participants
Race/Ethnicity, Customized Other/Unknown	10889 Participants n=5 Participants	10800 Participants n=7 Participants	10883 Participants n=5 Participants	10772 Participants n=4 Participants	10815 Participants n=21 Participants	10649 Participants n=10 Participants	64808 Participants n=115 Participants
Region of Enrollment United States	36526 participants n=5 Participants	36388 participants n=7 Participants	36541 participants n=5 Participants	36377 participants n=4 Participants	36289 participants n=21 Participants	36411 participants n=10 Participants	218532 participants n=115 Participants
Insurance Type Private	31307 Participants n=5 Participants	31164 Participants n=7 Participants	31302 Participants n=5 Participants	31129 Participants n=4 Participants	31148 Participants n=21 Participants	31167 Participants n=10 Participants	187217 Participants n=115 Participants
Insurance Type Public	4642 Participants n=5 Participants	4646 Participants n=7 Participants	4671 Participants n=5 Participants	4690 Participants n=4 Participants	4584 Participants n=21 Participants	4675 Participants n=10 Participants	27908 Participants n=115 Participants
Insurance Type Other/UNK	577 Participants n=5 Participants	578 Participants n=7 Participants	568 Participants n=5 Participants	558 Participants n=4 Participants	557 Participants n=21 Participants	569 Participants n=10 Participants	3407 Participants n=115 Participants
Adults with diabetes	3660 Participants n=5 Participants	3644 Participants n=7 Participants	3663 Participants n=5 Participants	3485 Participants n=4 Participants	3534 Participants n=21 Participants	3539 Participants n=10 Participants	21525 Participants n=115 Participants

PRIMARY outcome

Timeframe: 6 months

Population: Each row represents a combination of intervention conditions in our factorial design. Each column represents patient subpopulations which received different versions of the intervention. The number analyzed in each cell is the number from that column's subpopulation assigned to that row's intervention combination.