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Dry Eye Evaluation System Based on Bioinformatics

NCT ID: NCT04109170

Last Updated: 2019-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-09-23

Study Completion Date

2020-01-23

Brief Summary

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Dry eye is a common ocular surface disease of multifactorial etiology characterized by elevated tear osmolality and inflammation leading to a disrupted ocular surface. The latter is a risk factor for ocular surface infection, yet overt infection is not commonly seen clinically in the typical dry eye patient. This suggests that important innate mechanisms operate to protect the dry eye from invading pathogens. Understand the pathogenesis of dry eye will be the measure to prevention and treatment of dry eye.

In this essay, the investigators use the data of experiment in the patients with dry eye and normal, acquire their tear production, tear film stability, and surface damage. The investigators use weka to calculate the prediction accuracy of the 6 algorithm and select the best one, optimize the parameters to get the final prediction accuracy.

Detailed Description

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Conditions

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Dry Eye

Keywords

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Dry Eye Bioinformatics Data mining

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Dry Eye Group

This group of subjects were diagnosed with dry eye.

No interventions assigned to this group

Normal Control Group

This group of subjects had no dry eye symptoms and signs and belonged to the normal control group.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Dye Eye

Exclusion Criteria

* systemic disease (such as diabetes, glaucoma, or systemic collagen vascular disease), ocular disease, a history of tear supplement usage or contact lens wear during the past year,and pregnancy
Minimum Eligible Age

10 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Huaxia Eye Hospital Group

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Chi Zhang, PhD,MD

Role: PRINCIPAL_INVESTIGATOR

Huaxia Eye Hospital of Foshan

Locations

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Huaxia Eye Hosptial of Foshan

Foshan, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Chi Zhang, PhD,MD

Role: CONTACT

Phone: +86(757)83908467

Email: [email protected]

Gangping Zhao, MD

Role: CONTACT

Phone: +86(757)83903600

Email: [email protected]

Facility Contacts

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Chi Zhang, MD,PhD

Role: primary

Other Identifiers

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FSHX2019-01

Identifier Type: -

Identifier Source: org_study_id