Role of Lung Ultrasound In Assessment Of Recruitment Maneuvers In Ventilated Preterms With Respiratory Distress Syndrome and Its Correlation With Tracheal IL-6 Level
NCT ID: NCT04107090
Last Updated: 2019-09-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
44 participants
INTERVENTIONAL
2018-01-20
2019-05-20
Brief Summary
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1. Evaluate the efficacy of lung ultrasonography in detecting opening and closing lung pressures in ventilated preterm neonates with respiratory distress syndrome.
2. Determine the efficacy of lung ultrasonography in optimizing lung volume and its correlation with pulmonary inflammatory reaction as evidenced by IL-6 level in tracheal aspirate.
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Detailed Description
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The studied population included 44 preterm infants. Then they were allocated randomly to one of 2 groups in order by admission:
Group A: included 22 patients on whom the recruitment maneuver was applied guided by lung ultrasonography.
Group B: included 22 patients on whom the recruitment maneuver was not ultrasound guided. This is considered the control group.
Anthropometric measurements, gestational age, sex, mode of delivery, maternal disease and Apgar score were found to be matched in the two studied groups indicating successful randomization as seen in these balanced demographic variables between the groups.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
Group A: it included 22 patients on whom the recruitment manoeuvre was applied guided by lung ultrasonography.
Group B: it included 22 patients on whom the recruitment maneuver was not ultrasound guided. This is considered the control group.
OTHER
NONE
Study Groups
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US guided lung recruitment
Group A: it included 22 patients on whom the recruitment manoeuvre was applied guided by lung ultrasonography.
lung recruitment maneuver
Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome
tracheal IL-6 level
tracheal IL-6 level was measured before and after recruitment maneuver
US guided lung recruitment maneuver
Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome guided by lung ultrasound
Non US guided lung recruitment
Group B: it included 22 patients on whom the recruitment maneuver was not ultrasound guided. This is considered the control group.
lung recruitment maneuver
Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome
tracheal IL-6 level
tracheal IL-6 level was measured before and after recruitment maneuver
Interventions
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lung recruitment maneuver
Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome
tracheal IL-6 level
tracheal IL-6 level was measured before and after recruitment maneuver
US guided lung recruitment maneuver
Lung recruitment maneuver done for ventilated preterm neonates diagnosed with respiratory distress syndrome guided by lung ultrasound
Eligibility Criteria
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Inclusion Criteria
2. In need for invasive mechanical ventilation for RDS according to Downes Score .
Exclusion Criteria
1. Major upper or lower airway anomalies.
2. Significant congenital anomalies including cardiac, abdominal or respiratory.
3. Surgical cases
4. Inborn errors of metabolism
5. Early onset sepsis.
6. Meconium aspiration syndrome.
7. Hypoxic ischemic encephalopathy.
1 Hour
2 Days
ALL
No
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Dina Reda Fikry Kamel
Assistant Lecturer
Locations
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Ain Shams Univeristy
Cairo, , Egypt
Countries
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Other Identifiers
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Lung Ultrasound
Identifier Type: -
Identifier Source: org_study_id
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