Global Prospective Case Series Using a Single-Use Duodenoscope

NCT ID: NCT04103749

Last Updated: 2023-12-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

551 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-03-22

Study Completion Date

2023-01-05

Brief Summary

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Confirm procedural performance of the ExaltTM Model D Single-Use Duodenoscope in Endoscopic Retrograde Cholangio-Pancreatography (ERCP) and other duodenoscope-based procedures

Detailed Description

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This study is a prospective, multi-center case series of per standard of care ERCP procedures using a nonsignificant risk single-use duodenoscope. Up to 1000 cases will be included at up to 40 clinical sites. Patients who meet all eligibility criteria will be included and will have a clinically indicated ERCP procedure performed using the study device. Enrolled subjects will be followed for 30 days after their procedure.

Conditions

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Endoscopic Retrograde Cholangiopancreatography

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Exalt DScope 02

Subjects will have a clinically indicated per standard of care ERCP or other duodenoscope-based procedure performed using the Exalt single use duodenoscope study device. Subjects are considered enrolled after completing the study specific informed consent form.

Group Type EXPERIMENTAL

Exalt Model D Single-Use Duodenoscope

Intervention Type DEVICE

Subjects will have a clinically indicated per standard of care ERCP or other duodenoscope-based procedure performed with the Exalt single use duodenoscope study device.

Interventions

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Exalt Model D Single-Use Duodenoscope

Subjects will have a clinically indicated per standard of care ERCP or other duodenoscope-based procedure performed with the Exalt single use duodenoscope study device.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* Willing and able to comply with the study procedures and provide written informed consent to participate in the study
* Scheduled for a clinically indicated ERCP

Exclusion Criteria

* Potentially vulnerable subjects, including, but not limited to pregnant women
* Subjects for whom endoscopic techniques are contraindicated
* Patients who are currently enrolled in another investigational study that would directly interfere with the current study, without prior written approval from the sponsor
* Investigator discretion
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Adam Slivka, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh Medical Center

Marco Bruno, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Erasmus Medical Center

Locations

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University of California Los Angeles Medical Center

Los Angeles, California, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

Indianapolis University Hospital

Indianapolis, Indiana, United States

Site Status

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

North Shore University Hospital

Manhasset, New York, United States

Site Status

Cornell Medical Center

New York, New York, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Site Status

The University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Site Status

Virginia Mason Medical Center

Seattle, Washington, United States

Site Status

Metro North Hospital and Health Services

Brisbane, , Australia

Site Status

St. Michael's Hospital - Unity Health

Toronto, , Canada

Site Status

Institut Paoli-Calmettes

Marseille, , France

Site Status

Evangelisches Krankenhaus Düsseldorf

Düsseldorf, North Rhine-Westphalia, Germany

Site Status

Prince of Wales Hospital

Hong Kong, , Hong Kong

Site Status

Asian Institute of Gastroenterology

Hyderabad, Telangana, India

Site Status

Apollo Multispeciality Hospitals

Kolkata, West Bengal, India

Site Status

Humanitas University

Milan, , Italy

Site Status

Erasmus University Medical Center of Rotterdam

Rotterdam, , Netherlands

Site Status

Singapore General Hospital

Singapore, , Singapore

Site Status

Dr. George Mukhari Academic Hospital

Ga-Rankuwa, , South Africa

Site Status

Countries

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United States Australia Canada France Germany Hong Kong India Italy Netherlands Singapore South Africa

References

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Bruno MJ, Beyna T, Carr-Locke D, Chahal P, Costamagna G, Devereaux B, Giovannini M, Goenka MK, Khor C, Lau J, May G, Muthusamy VR, Patel S, Petersen BT, Pleskow DK, Raijman I, Reddy DN, Repici A, Ross AS, Sejpal DV, Sherman S, Siddiqui UD, Ziady C, Peetermans JA, Rousseau MJ, Slivka A; EXALT Single-use Duodenoscope Study Group. Global prospective case series of ERCPs using a single-use duodenoscope. Endoscopy. 2023 Dec;55(12):1103-1114. doi: 10.1055/a-2131-7180. Epub 2023 Jul 18.

Reference Type DERIVED
PMID: 37463599 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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E7156

Identifier Type: -

Identifier Source: org_study_id