Benralizumab Exacerbation Study

NCT ID: NCT04102800

Last Updated: 2024-04-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 157 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-09-30
• Study Completion Date: 2024-04-23

Brief Summary

This is an exploratory study, the focus of which is to understand the nature of asthma exacerbations that occur despite open label benralizumab therapy in severe eosinophilic asthma.

Detailed Description

A phase IV, open-label, prospective, multi-centre cohort study in patients with severe eosinophilic asthma (Global Initiative for Asthma [GINA] steps 4 and 5 classification of asthma severity) who will be treated with benralizumab injections. The study is exploratory and will assess deteriorations in asthma control (exacerbations) to characterise the clinical severity of each exacerbation and the airway and systemic inflammatory phenotype associated with these events. Clinical assessment and management of each exacerbation will be in line with standard clinical guidelines. 150 participants will be recruited and receive treatment for either 56 or 80 weeks.

Conditions

Asthma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment

Benralizumab 30mg by subcutaneous injection, 18 months treatment for the first 75 participants enrolled, 12 months treatment for participants 76-150

Group Type: OTHER

Benralizumab

Intervention Type: DRUG

subcutaneous injection

Interventions

Benralizumab

subcutaneous injection

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• able and willing to provide written informed consent and to comply with the study protocol, including being able to attend for assessment during a symptomatic deterioration
• severe asthma confirmed after assessment by an asthma specialist, requiring treatment with high dose inhaled corticosteroids (ICS) as per BTS criteria [>1000 fluticasone proportionate equivalent] and >1 additional drug for asthma (e.g. long acting beta 2 antagonist (LABA)/leukotriene receptor antagonist/theophylline/long acting muscarinic antagonist) at screening [participants may be included with a lower dose of current ICS at the discretion of the investigator if previous high ICS dose had led to side effects]
• Adherent with background asthma medication in the opinion of the investigator [adherence assessments as per local practice]
• Assessed and treatment optimised for any significant asthma-related co-morbidities
• Considered suitable by an asthma specialist for treatment with a monoclonal antibody to block the Interleukin-5 pathway as per local practice. Participants will have: a) recorded blood eosinophil count ≥0.3 x 109/L within the past year along with a history of either ≥4 asthma exacerbations requiring high dose oral corticosteroids* and/or maintenance systemic corticosteroids equivalent to prednisolone ≥5 mg/day for 6 months or longer OR b) recorded blood eosinophil count ≥0.4 x 109/L within the past year along with a history of ≥ 3 asthma exacerbations requiring high dose oral corticosteroids*

• [Exacerbations of asthma in the past year will be defined as worsening of asthma symptoms leading to treatment with prednisolone ≥30 mg oral corticosteroids for ≥3 days or an increase ≥ 10mg in oral corticosteroids for at least 3 days for patients on maintenance oral steroids] as defined by the ERS/ATS Task Force

5. Other ongoing immunosuppressive/ immunomodulating therapy [e.g. methotrexate, ciclosporine, azathioprine] other than oral corticosteroids for asthma.

• Bronchial thermoplasty conducted within 6 months of Visit 1.
• History of known immunodeficiency disorder including a previous positive human immunodeficiency virus (HIV) test
• Active or suspected Helminth infection. Patients with helminth infections must be excluded until the infection has been treated
• Known hypersensitivity to benralizumab (the active substance) or any of the excipients [Histidine, Histidine hydrochloride monohydrate, Trehalose dihydrate, Polysorbate 20, water for injections]
• Women of child bearing potential (WoCBP) who are not willing to use highly effective contraception during treatment with benralizumab and for 16 weeks after the last dose. WoCBP will be required to undergo a urine pregnancy test prior to administration of each benralizumab injection.
• Current malignancy, or history of malignancy, except for:

1. patients who have had non-melanoma skin cancers or in situ carcinoma of the cervix - these patients are eligible provided that the patient is in remission and curative therapy was completed at least 12 months prior to the date informed consent is obtained. b) Patients who have had other malignancies are eligible provided that the patient is in remission and curative therapy was completed at least 5 years prior to the date informed consent is obtained.

Exclusion Criteria

• Acute exacerbation requiring high dose oral corticosteroids in the 2 weeks prior to Visit 1 or during the screening period. Such patients would be re-assessed after 2 weeks for re-screening.
• Other clinically significant medical disease or uncontrolled concomitant disease that is likely, in the opinion of the investigator, to require a change in therapy or impact the ability to participate in the study.
• History of current alcohol, drug, or chemical abuse or past abuse that would impair or risk the subject's full participation in the study, in the opinion of the investigator.
• Female patients who are pregnant or lactating or planning a family
• Current smoker [history of smoking [including e-cigarettes] in the past 3 months prior to Visit 1.
• Treatment with any of the following prior to Visit 1 or during the study

1. any biologic medicine for asthma or an immunomodulating biologic agent for other conditions in the 3 months prior to Visit 1

2. an investigational agent within 30 days of Visit 1 (or five half lives of the investigational agent, whichever is longer).

3. Administration of live attenuated vaccine 30 days prior to Visit 1. Other types of approved vaccines are allowed.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Glasgow

OTHER

Sponsor Role: collaborator

AstraZeneca

INDUSTRY

Sponsor Role: collaborator

Queen's University, Belfast

OTHER

Sponsor Role: collaborator

Bosch Healthcare Solutions GmbH

INDUSTRY

Sponsor Role: collaborator

InHealthcare

UNKNOWN

Sponsor Role: collaborator

University of Leicester

OTHER

Sponsor Role: collaborator

University of Plymouth

OTHER

Sponsor Role: collaborator

Vitalograph

UNKNOWN

Sponsor Role: collaborator

NHS Greater Glasgow and Clyde

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Belfast City Hospital

Belfast, , United Kingdom

Birmingham Heartlands Hospital

Birmingham, , United Kingdom

Bradford Royal Infirmary

Bradford, , United Kingdom

Gartnavel General Hospital

Glasgow, , United Kingdom

Castle Hill Hospital

Hull, , United Kingdom

Glenfield Hospital

Leicester, , United Kingdom

Royal Liverpool University Hospital

Liverpool, , United Kingdom

Guy's and St Thomas's Hospital

London, , United Kingdom

Royal Brompton Hospital

London, , United Kingdom

Royal Free Hospital

London, , United Kingdom

Wythenshawe Hospital

Manchester, , United Kingdom

Freeman Hospital

Newcastle, , United Kingdom

Churchill Hospital

Oxford, , United Kingdom

Queen Alexandra Hospital

Portsmouth, , United Kingdom

Southampton General Hospital

Southampton, , United Kingdom

Countries

United Kingdom

References

Butler CA, Heaney LG. Fractional exhaled nitric oxide and asthma treatment adherence. Curr Opin Allergy Clin Immunol. 2021 Feb 1;21(1):59-64. doi: 10.1097/ACI.0000000000000704.

Reference Type: DERIVED

PMID: 33369570 (View on PubMed)

Other Identifiers

GN17RM684

Identifier Type: -

Identifier Source: org_study_id