Osteoradionecrosis and PENTOCLO Protocol: Retrospective Study

NCT ID: NCT04097847

Last Updated: 2019-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

96 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-02

Study Completion Date

2019-04-01

Brief Summary

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osteoradionecrosis (ORN) affects up to 30% of irradiated patients and can occur up to several decades after stopping treatment. Differents therapeutics exist but there is no consensus concerning the management of the maxillary ORN. The understanding of new pathological mechanisms opens the way to new therapeutic perspectives.

Detailed Description

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Conditions

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Osteoradionecrosis of Jaw

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Pentoxifylline-Tocopherol-Clodronate

the aim of this retrospective study is to analyze from patient records the impact of the PENTOCLO protocol on maxillofacial osteoradionecrosis at Brest Hospital University, France.

Intervention Type DRUG

Other Intervention Names

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Pentoclo

Eligibility Criteria

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Inclusion Criteria

* Patient over 18 being or having been treated by pentoclo combination for an osteoradionecrosis of the jaw

Exclusion Criteria

* Tumoral recidivism
* Precocious stop of pentoclo
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHRU de Brest

Brest, , France

Site Status

Countries

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France

Other Identifiers

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OPEN (29BRC17.0115)

Identifier Type: -

Identifier Source: org_study_id

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