Trial Outcomes & Findings for The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function (NCT NCT04092439)

NCT ID: NCT04092439

Last Updated: 2024-07-30

Results Overview

Flow mediated dilation

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 18 participants
• Primary outcome timeframe: Two weeks
• Results posted on: 2024-07-30

Participant Flow

Participant milestones

Measure	Experimental: Watermelon Juice Drink, Then Placebo Participants first received 500 ml of watermelon juice for the first 2 weeks. After a 2 week washout, they then received 500 ml of a watermelon-flavored placebo drink.	Experimental: Placebo, Then Watermelon Juice Drink Participants first received 500 ml of watermelon flavor placebo drink for two weeks. After a 2 week washout, participants then received 2 week of 500 ml of watermelon juice for daily consumption.
Overall Study STARTED	10	8
Overall Study COMPLETED	10	7
Overall Study NOT COMPLETED	0	1

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Measure	Watermelon Juice First, Then Placebo n=10 Participants 100% watermelon juice Watermelon Juice: 100% Watermelon Juice	Placebo First Then, Watermelon Juice n=8 Participants Fructose matched control Watermelon Juice: 100% Watermelon Juice	Total n=18 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=10 Participants	0 Participants n=8 Participants	0 Participants n=18 Participants
Age, Categorical Between 18 and 65 years	10 Participants n=10 Participants	8 Participants n=8 Participants	18 Participants n=18 Participants
Age, Categorical >=65 years	0 Participants n=10 Participants	0 Participants n=8 Participants	0 Participants n=18 Participants
Age, Continuous	23.4 years STANDARD_DEVIATION 2.7 • n=10 Participants	24.2 years STANDARD_DEVIATION 3.4 • n=8 Participants	23.8 years STANDARD_DEVIATION 3.0 • n=18 Participants
Sex: Female, Male Female	8 Participants n=10 Participants	4 Participants n=8 Participants	12 Participants n=18 Participants
Sex: Female, Male Male	2 Participants n=10 Participants	4 Participants n=8 Participants	6 Participants n=18 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
Region of Enrollment United States	10 Participants n=10 Participants	8 Participants n=8 Participants	18 Participants n=18 Participants
Body Mass Index	21.9 kg/m2 STANDARD_DEVIATION 1.6 • n=10 Participants	25.0 kg/m2 STANDARD_DEVIATION 3.9 • n=8 Participants	23.3 kg/m2 STANDARD_DEVIATION 3.2 • n=18 Participants

PRIMARY outcome

Timeframe: Two weeks

Population: Young healthy adults

Flow mediated dilation

Outcome measures

Measure	Placebo n=17 Participants 500 ml of watermelon flavored drink	Watermelon Juice n=17 Participants Young healthy adults
Endothelial Function	3.31 millimeters Standard Deviation 0.65	3.53 millimeters Standard Deviation .65

SECONDARY outcome

Timeframe: Two weeks

Population: Young healthy adults

microvascular blood flow

Outcome measures

Measure	Placebo n=17 Participants 500 ml of watermelon flavored drink	Watermelon Juice n=17 Participants Young healthy adults
Postprandial Blood Flow	36.0 100 ml tissue/min Standard Deviation 20.5	51.0 100 ml tissue/min Standard Deviation 29.1

Adverse Events

Watermelon Juice

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Placebo

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Tim Allerton, Ph.D.

Pennington Biomedical Research Center

Phone: 225-763-2940

Email: timothy.allerton@pbrc.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place