Light Therapy on Sleep Quality in Dialysis Patients

NCT ID: NCT04089397

Last Updated: 2020-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-01

Study Completion Date

2020-05-11

Brief Summary

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Sleep disorders are common in dialysis patients. At present, the management of insomnia in patients with chronic renal failure is not significantly different from that of the general population, which focuses on the management of co-factors, sleep hygiene, and cognitive-behavioral therapy.

Light therapy is a paramedical practice that involves exposing a patient to a light intensity greater than 5000 Lux (usually 10,000 Lux) for 30 minutes in the morning between 7:00 and 8:30. Its impact is partly mediated by an improvement in the nycthemeral cycle of melatonin.

Light therapy may improve sleep disorders and anxious-depressive elements as suggested in the literature. This technique has not yet been evaluated in dialysis patients, whereas easy to set up.

Detailed Description

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Sleep disorders are common in dialysis patients. Indeed, several studies have reported that the prevalence of these disorders is higher than that of the general population. At present, the management of insomnia in patients with chronic renal failure is not significantly different from that of the general population, which focuses on the management of co-factors, sleep hygiene, and cognitive-behavioral therapy.

Light therapy is a paramedical practice that involves exposing a patient to a light intensity greater than 5000 Lux (usually 10,000 Lux) for 30 minutes in the morning between 7:00 and 8:30. Its impact is partly mediated by an improvement in the nycthemeral cycle of melatonin. Light therapy has been studied in several pathologies. In the context of renal insufficiency, only one randomized study was conducted in renal transplant patients: out of 30 patients, the effect of light therapy regained an 11-minute increase in sleep latency, an earlier awakening of 24 minutes, and a gain in the DASS-21 depression score of 1.7 points while there was no improvement in his three parameters in the control group. Interest in light therapy has also been evaluated in seasonal and non-seasonal depression. In a meta-analysis of 458 patients, light therapy adjuvant use was as effective as the addition of a second molecule.

Light therapy may improve sleep disorders and anxious-depressive elements as suggested in the literature. This technique has not yet been evaluated in dialysis patients, whereas easy to set up.

We therefore wish to set up a clinical study to determine whether a light therapy technique in the morning during dialysis or at home improves the quality of sleep of chronic hemodialysis patients. The secondary objectives will be to specify the improved sleep parameters, to evaluate the impact on the anxious-depressive score, the arterial hypertension, and the nutritional state, and the residual effect of light therapy.

The aim of this trial is to determine whether a light therapy technique in the morning during dialysis or at home improves the quality of sleep of chronic hemodialysis patients.

Conditions

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Chronic Renal Failure Sleep Disorder Hemodialysis Light Therapy

Keywords

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light therapy in sleep disorders of dialysis patients

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized open-label trial
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Light therapy group

Five weeks of light therapy, with 3 weekly sessions of 30 minutes, to be performed between 8:00 to 10:00, the days of dialysis (at home, for patients dialyzing the afternoon, or during dialysis for patients dialyzing in the morning)

Group Type EXPERIMENTAL

Light Therapy

Intervention Type DEVICE

Five weeks of light therapy, with 3 weekly sessions of 30 minutes, to be performed between 8:00 to 10:00, the days of dialysis

Control group

Usual care, without light therapy

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Light Therapy

Five weeks of light therapy, with 3 weekly sessions of 30 minutes, to be performed between 8:00 to 10:00, the days of dialysis

Intervention Type DEVICE

Other Intervention Names

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Lumie BrazilĀ® (light therapy device for the treatment of seasonal affective disorders)

Eligibility Criteria

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Inclusion Criteria

* Patient in conventional hemodialysis or hemodiafiltration for at least 3 months
* Patient requiring a dialysis session three times a week in the investigational site
* Patient benefiting from a social security scheme
* Patient informed and having given his free and informed consent to participate in the study

Exclusion Criteria

* Patient with binocular blindness and / or age-related macular degeneration
* Eye fatigue
* Patient who has undergone a recent eye surgery (less than 3 months) or for whom such an operation is planned in the next 20 weeks
* Patient taking medications known to be responsible for photosensitivity
* Pregnant or lactating woman
* Patient under guardianship or curatorship
* Patient unable to give free and informed consent

Exclusion during the study - premature stop

* Wishes of the patient or the physician
* Appearance of unexplained visual disturbances
* Kidney transplant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Annecy Genevois

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Benoit Franko, MD

Role: PRINCIPAL_INVESTIGATOR

CH Annecy Genevois

Locations

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CH Annecy Genevois

Pringy, , France

Site Status

Countries

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France

Other Identifiers

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2018-A02276-49

Identifier Type: OTHER

Identifier Source: secondary_id

17-11-LUMIDIAL

Identifier Type: -

Identifier Source: org_study_id