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Correlates of Left Ventricular Global Longitudinal Strain and Surgical Intervention on Myocardial Bridges

NCT ID: NCT04082546

Last Updated: 2020-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-26

Study Completion Date

2020-09-03

Brief Summary

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To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal medical therapy (OMT).

Detailed Description

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The present study is enrolling all the MBs-patients who underwent angina surgical relief or medical treatment at the "Ospedali Riuniti" of Ancona, Italy, and the "University Hospital" of Chieti, Italy. All the participants will be examined utilizing echocardiography before and after the treatment. The two-dimensional speckle-tracking analysis will be performed with an off-line dedicated software from the apical 4-chambers-view. All the unroofing procedures will be performed under cardiopulmonary bypass.

Conditions

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Myocardial Bridge of Coronary Artery

Keywords

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Coronary abnormalities Angina Global longitudinal strain Speckle-traking echocardiography Myocardial ischemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Surgical unroofing

Refractory angina to medical treatment (beta-blockers or calcium channels blockers)

Surgical unroofing of muscle-briged coronary artery

Intervention Type PROCEDURE

Medical therapy with beta-blockers or calcium-channels blockers

Medical treatment

Responders to medical treatment for angina relief

Surgical unroofing of muscle-briged coronary artery

Intervention Type PROCEDURE

Medical therapy with beta-blockers or calcium-channels blockers

Interventions

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Surgical unroofing of muscle-briged coronary artery

Medical therapy with beta-blockers or calcium-channels blockers

Intervention Type PROCEDURE

Other Intervention Names

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Medical treatment

Eligibility Criteria

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Inclusion Criteria

* Myocardial bridge of the anterior descending left coronary artery

Exclusion Criteria

* Poor echocardiographic imaging quality
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Azienda Ospedaliero, Universitaria Ospedali Riuniti

OTHER

Sponsor Role collaborator

ITAB - Institute for Advanced Biomedical Technologies

OTHER

Sponsor Role lead

Responsible Party

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Francesco Bianco

Medical doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Francesco Bianco, MD

Role: PRINCIPAL_INVESTIGATOR

G. d'Annunzio University

Locations

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Ospedali Riuniti

Ancona, , Italy

Site Status

Countries

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Italy

References

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Alegria JR, Herrmann J, Holmes DR Jr, Lerman A, Rihal CS. Myocardial bridging. Eur Heart J. 2005 Jun;26(12):1159-68. doi: 10.1093/eurheartj/ehi203. Epub 2005 Mar 11.

Reference Type BACKGROUND
PMID: 15764618 (View on PubMed)

Corban MT, Hung OY, Eshtehardi P, Rasoul-Arzrumly E, McDaniel M, Mekonnen G, Timmins LH, Lutz J, Guyton RA, Samady H. Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies. J Am Coll Cardiol. 2014 Jun 10;63(22):2346-2355. doi: 10.1016/j.jacc.2014.01.049. Epub 2014 Feb 26.

Reference Type BACKGROUND
PMID: 24583304 (View on PubMed)

Cerit L, Duygu H. Myocardial bridging and sudden death. Int J Cardiol. 2017 Feb 15;229:11. doi: 10.1016/j.ijcard.2016.11.308. Epub 2016 Dec 1. No abstract available.

Reference Type BACKGROUND
PMID: 27923515 (View on PubMed)

Zhang M, Yang J, Ma C, Liu M. Longitudinal strain measured by two-dimensional speckle tracking echocardiography to evaluate left ventricular function in patients with myocardial bridging of the left anterior descending coronary artery. Echocardiography. 2019 Jun;36(6):1066-1073. doi: 10.1111/echo.14357. Epub 2019 May 13.

Reference Type BACKGROUND
PMID: 31087389 (View on PubMed)

Alessandri N, Dei Giudici A, De Angelis S, Urciuoli F, Garante MC, Di Matteo A. Efficacy of calcium channel blockers in the treatment of the myocardial bridging: a pilot study. Eur Rev Med Pharmacol Sci. 2012 Jun;16(6):829-34.

Reference Type BACKGROUND
PMID: 22913217 (View on PubMed)

Other Identifiers

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CCPC001

Identifier Type: -

Identifier Source: org_study_id