Carbon Ion Radiotherapy for Locally Advanced Pancreatic Cancer

NCT ID: NCT04082455

Last Updated: 2023-12-01

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 49 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-04-01
• Study Completion Date: 2024-06-01

Brief Summary

The aim of this study is to evaluate the toxicity and tolerance of carbon ion radiotherapy for locally advanced pancreatic carcinoma (LAPC)

Detailed Description

The carbon dose of 60-67.5GyE in 15 fractions was delivered to clinical target volume (CTV). The dose limiting toxicity (DLT) was defined as CTCAE grade 3 or higher of non-hematological toxicity (G3). The acute and late toxicities, overall survival (OS), progression-free survival (PFS), local progression-free survival (LPFS) and distant metastasis-free survival (DMFS) were the endpoints.

Conditions

Pancreatic Carcinoma

Keywords

carbon ion radiotherapy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

carbon ion radiotherapy

carbon ion radiotherapy

Group Type: EXPERIMENTAL

carbon ion radiotherapy

Intervention Type: RADIATION

carbon ion radiotherapy

Interventions

carbon ion radiotherapy

carbon ion radiotherapy

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

1. The histologically or cytologically confirmed, or the clinically diagnosed by clinical diagnosis criterion proposed by Pancreatic Cancer Committee of Chinese Anti-Cancer Association, which was based on evidences of (1). Typical symptoms of abdominal and/or back pain; (2). CA19-9 increased over the normal up limit; (3). A pancreatic mass shown on CT or MRI; and (4). SUV of PET-CT in mass increased compared to that in normal pancreas;

2. Unresectable LAPC defined by the criteria of (NCCN) guidelines (Version 1. 2013), or refusal to surgery;

3. Gastrointestinal tract (GI) not invaded;

4. ECOG Performance Status 0-1 within 30 days prior to registration;

5. Age of ≥ 18 years old;

6. Enough hematological function (white blood cell count ≥ 3.0×109/L; platelets ≥50×109/L; hemoglobin ≥ 90 g/L);

7. Enough liver and kidney functions (creatinine <110gmol/L; urea nitrogen <7.1mmol/L; bilirubin < 1.5 x ULN, ALT and AST ≤ 2.5 x ULN);

8. No evidence of distant metastases, based upon PET, CT, or MRI images of the chest, abdomen and pelvis within 30 days prior to registration;

9. Informed consent form obtained.

Exclusion Criteria

1. No pathological evidence of malignant tumor;

2. ECOG>=2；

3. Liver, kidney and bone marrow function are poor and not adequate for treatment;

4. Side effect of previous treatment is not covered yet, eg. The interval between TACE and other anti-tumor therapy is less than one month;

5. Prior radiation therapy to the abdomen or radioactive particle implantation;

6. cardiac pacemaker or other metal implantation whose function may be disturbed by high energy beam or which affect the dose in target volume;

7. Dose constrain of normal liver, digested system and other OAR could not reach the expecting safe dose constrain;

8. The patient could not get benefit from proton or heavy ion radiotherapy in physician's opinion;

9. Comitant diseases or affecters which could affect the proton or heavy ion radiotherapy;

10. Pregnancy（blood or urine β-HCG certified）or lactation;

11. Drug or alcohol abused;

12. HIV positive, including received anti-retrovirus treatment; chronic hepatitis B virus replication stage; hepatitis C active stage; syphilis active stage;

13. HBV positive, hepatitis B virus replication stage, need to be treated with anti-virus treatment, but could not receive anti-virus treatment because of comitant disease;

14. Psychiatric history, possibly affecting the completion of treatment;

15. patients with serious complications that might affect radiotherapy， including 1）unstable angina pectoris requiring hospitalization in the last 6 months，congestive heart failure，myocardial infarction； 2）acute bacterial or systemic fungal infections； 3）exacerbation of chronic obstructive pulmonary disease ( COPD) or other respiratory system disease requiring hospitalization 4）hepatic function insufficiency or renal function insufficiency 5） immunosuppressed patients

16. patients with connective tissue disease such as active scleroderma or lupus and so on, which is contraindication for radiotherapy

17. patients can't understand treatment goal or unwilling/unable to sign up inform consent form；

18. no civil capability or limited civil capacity.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Proton and Heavy Ion Center

OTHER

Sponsor Role: lead

Responsible Party

Guoliang Jiang

director of clinical technical committee, professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Guo-Liang Jiang, Dr.

Role: PRINCIPAL_INVESTIGATOR

Shanghai Proton and Heavy Ion Center

Locations

Shanghai Proton and Heavy Ion Center

Shanghai, Shanghai Municipality, China

Countries

China

Other Identifiers

SPHIC-TR-PaCa2018-03

Identifier Type: -

Identifier Source: org_study_id