Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
48 participants
INTERVENTIONAL
2019-12-04
2022-06-24
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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10 µg/kg LY3471851
Participants received subcutaneous (SC) injection of 10 microgram per kilogram (μg/kg) LY3471851 every 2 weeks for a treatment period of 12 weeks.
LY3471851
Administered SC
12 µg/kg LY3471851
Participants received subcutaneous injection of 12 μg/kg LY3471851 every 2 weeks for a treatment period of 12 weeks.
LY3471851
Administered SC
24 µg/kg LY3471851
Participants received subcutaneous injection of 24 μg/kg LY3471851 every 2 weeks for a treatment period of 12 weeks.
LY3471851
Administered SC
Placebo
Participants received subcutaneous injection of placebo every 2 weeks for a treatment period of 12 weeks.
Placebo
Administered SC
Interventions
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LY3471851
Administered SC
Placebo
Administered SC
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Have active AD according to study specific criteria
* Be willing and able to undergo skin biopsies
Exclusion Criteria
* Have received certain systemic medications for AD within 4 weeks prior to baseline
* Have received LY3471851 previously
18 Years
70 Years
ALL
No
Sponsors
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Eli Lilly and Company
INDUSTRY
Nektar Therapeutics
INDUSTRY
Responsible Party
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Principal Investigators
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Study Director
Role: STUDY_DIRECTOR
Nektar Therapeutics
Locations
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Arkansas Research Trials, LLC
North Little Rock, Arkansas, United States
California Dermatology & Clinical Research Institute
Encinitas, California, United States
Center For Dermatology Clinical Research, Inc.
Fremont, California, United States
Therapeutics Clinical Research
San Diego, California, United States
Clinical Science Institute
Santa Monica, California, United States
Miami Dermatology and Laser Research
Miami, Florida, United States
ForCare Clinical Research
Tampa, Florida, United States
Medical Dermatology Specialists
Sandy Springs, Georgia, United States
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana, United States
Skin Sciences
Louisville, Kentucky, United States
Derm Center
Troy, Michigan, United States
ActivMed Practices and Research
Portsmouth, New Hampshire, United States
Remington-Davis, Inc
Columbus, Ohio, United States
Unity Clinical Research
Oklahoma City, Oklahoma, United States
Paddington Testing Company Inc
Philadelphia, Pennsylvania, United States
DermDox Centers for Dermatology
Sugarloaf, Pennsylvania, United States
Studies in Dermatology, LLC
Cypress, Texas, United States
Rodgers Dermatology
Frisco, Texas, United States
Progressive Clinical Research
San Antonio, Texas, United States
Complete Dermatology
Sugar Land, Texas, United States
Countries
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References
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Silverberg JI, Rosmarin D, Chovatiya R, Bieber T, Schleicher S, Beck L, Gooderham M, Chaudhry S, Fanton C, Yu D, Levy J, Liu Y, Miyazaki T, Tagliaferri M, Schmitz C, Nirula A, Kotzin B, Zalevsky J. The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials. Nat Commun. 2024 Oct 25;15(1):9230. doi: 10.1038/s41467-024-53384-1.
Related Links
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A Study of LY3471851 in Participants With Eczema
Other Identifiers
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J1P-MC-KFAD
Identifier Type: OTHER
Identifier Source: secondary_id
17240
Identifier Type: -
Identifier Source: org_study_id
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