Clozapine and Haematologic Malignancies: Observational and Retrospective Study Using the WHO Pharmacovigilance Database

NCT ID: NCT04074213

Last Updated: 2019-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1000000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-01

Study Completion Date

2024-08-01

Brief Summary

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Clozapine may lead to various adverse reactions, including neutropenia and agranulocytosis. This study investigates reports of lymphoma and leukaemias for clozapine in the World Health Organization's (WHO) global database of individual safety case reports (VigiBase).

Detailed Description

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Clozapine is responsible of a wide range of adverse side effects.The investigators use VigiBase, the World Health Organization (WHO) database of individual safety case reports, to identify cases of haematologic malignancies following treatment with clozapine.

Conditions

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Lymphoma Leukemia

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Haematologic malignancies with clozapine

Cases reported in the World Health Organization (WHO) database of patients treated by Clozapine, with a chronology compatible with the drug toxicity

Clozapine

Intervention Type DRUG

Clozapine treatment

Interventions

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Clozapine

Clozapine treatment

Intervention Type DRUG

Other Intervention Names

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Clozapine treatment

Eligibility Criteria

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Inclusion Criteria

* Case reported in the World Health Organization (WHO) database of individual safety case reports to 03/05/2019
* Adverse events reported were including the MedDRA terms: Malignant Lymphoma (SMQ), Leukaemia (HLGT)
* Patients treated with at least one liable antipsychotic drug (ATC class N05A)

Exclusion Criteria

* Chronology not compatible between the drug and the toxicity
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Caen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Basile Chrétien, PharmD, MSc

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Caen

Locations

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Caen University Hospital, Department of Pharmacology

Caen, Normandy, France

Site Status RECRUITING

Countries

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France

Central Contacts

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Basile Chrétien, PharmD, MSc

Role: CONTACT

Phone: +33231064672

Email: [email protected]

Facility Contacts

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Basile Chrétien, PharmD, MSc

Role: primary

Other Identifiers

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19-916

Identifier Type: -

Identifier Source: org_study_id