Apple Cider Vinegar for the Prevention of Urinary Lithiasis (APUL)
NCT ID: NCT04073719
Last Updated: 2019-08-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2019-09-01
2022-05-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Apple Cider Vinegar + Coconut Water
Patients will drink apple cider vinegar for 7 days. After a washout period of 2 weeks, patients will then drink coconut water for 7 days.
Apple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
Apple Cider Vinegar + Citric Soda
Patients will drink apple cider vinegar for 7 days. After a washout period of 2 weeks, patients will then drink citric soda for 7 days.
Apple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
Apple Cider Vinegar + Lemonade
Patients will drink apple cider vinegar for 7 days. After a washout period of 2 weeks, patients will then drink lemonade for 7 days.
Apple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
Coconut Water + Apple Cider Vinegar
Patients will drink coconut water for 7 days. After a washout period of 2 weeks, patients will then drink apple cider vinegar for 7 days.
Apple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
Coconut Water + Citric Soda
Patients will drink coconut water for 7 days. After a washout period of 2 weeks, patients will then drink citric soda for 7 days.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Coconut Water + Lemonade
Patients will drink coconut water for 7 days. After a washout period of 2 weeks, patients will then drink lemonade for 7 days.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Citric Soda + Apple Cider Vinegar
Patients will drink citric soda for 7 days. After a washout period of 2 weeks, patients will then drink apple cider vinegar for 7 days.
Apple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Citric Soda + Coconut Water
Patients will drink citric soda for 7 days. After a washout period of 2 weeks, patients will then drink coconut water for 7 days.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Citric Soda + Lemonade
Patients will drink citric soda for 7 days. After a washout period of 2 weeks, patients will then drink lemonade for 7 days.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Lemonade + Apple Cider Vinegar
Patients will drink lemonade for 7 days. After a washout period of 2 weeks, patients will then drink apple cider vinegar for 7 days.
Apple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
Lemonade + Coconut Water
Patients will drink lemonade for 7 days. After a washout period of 2 weeks, patients will then drink coconut water for 7 days.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Lemonade + Citric Soda
Patients will drink lemonade for 7 days. After a washout period of 2 weeks, patients will then drink citric soda for 7 days.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Interventions
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Apple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
Other Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Pregnant females
* History of chronic kidney disease
* History of urolithiasis
* Currently taking medications that interfere with urinary electrolyte excretion (thiazide and loop diuretics)javascript:document.
* History of Diabetes
18 Years
65 Years
ALL
Yes
Sponsors
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United States Naval Medical Center, San Diego
FED
Responsible Party
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Christine Herforth
Urology Resident
Central Contacts
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References
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Barcelo P, Wuhl O, Servitge E, Rousaud A, Pak CY. Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol. 1993 Dec;150(6):1761-4. doi: 10.1016/s0022-5347(17)35888-3.
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Kang DE, Maloney MM, Haleblian GE, Springhart WP, Honeycutt EF, Eisenstein EL, Marguet CG, Preminger GM. Effect of medical management on recurrent stone formation following percutaneous nephrolithotomy. J Urol. 2007 May;177(5):1785-8; discussion 1788-9. doi: 10.1016/j.juro.2007.01.061.
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Shishehbor F, Mansoori A, Sarkaki AR, Jalali MT, Latifi SM. Apple cider vinegar attenuates lipid profile in normal and diabetic rats. Pak J Biol Sci. 2008 Dec 1;11(23):2634-8. doi: 10.3923/pjbs.2008.2634.2638.
Other Identifiers
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NMCSD.2019.0026
Identifier Type: -
Identifier Source: org_study_id