A Study to Evaluate the Long Term Safety of OTX-TP (Sustained Release Travoprost) Intracanalicular Insert

NCT ID: NCT04061044

Last Updated: 2023-06-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-07-10

Study Completion Date

2020-09-22

Brief Summary

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To evaluate the long term safety of repeat dose OTX-TP, a sustained release travoprost drug product, placed in the canaliculus of the eyelid in the treatment of subjects with open-angle glaucoma or ocular hypertension.

Detailed Description

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Conditions

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Open Angle Glaucoma and Ocular Hypertension

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment

Group Type EXPERIMENTAL

Ophthalmic Insert

Intervention Type DRUG

Travoprost, 0.32 mg

Interventions

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Ophthalmic Insert

Travoprost, 0.32 mg

Intervention Type DRUG

Other Intervention Names

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OTX-TP

Eligibility Criteria

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Inclusion Criteria

* Had prior bilateral treatment and completion, through a minimum of week 12, of the OTX-16-002 trial
* Are informed of the nature of the study and subject is able to comply with study requirements and visit schedule for one year
* Have provided written informed consent, approved by the appropriate Institutional Review Board

Exclusion Criteria

* Had more than 1 replacement, per eye, during participation in the OTX-16-002 trial
* Had punctal or canaliculi related adverse events during the OTX-16-002 trial which required discontinuation (e.g., canaliculitis)
* Used prohibited medications during the OTX-16-002 study, or the period between OTX-16-002 and this trial (with the exception of short term medication used to treat an adverse event or rescue therapy)
* Missed more than 2 visits during participation in the OTX-16-002 trial
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ocular Therapeutix, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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ApexEye

Cincinnati, Ohio, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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CLN-Protocol-0047

Identifier Type: -

Identifier Source: org_study_id

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