SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study

NCT ID: NCT04054401

Last Updated: 2023-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-06

Study Completion Date

2024-10-31

Brief Summary

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The purpose of the study is to evaluate the safety and tolerability of DRG stimulation when placing a neurostimulator during the same procedure as implantation of spinal fixation with or without interbody cage systems in patients with chronic back and/or leg pain requiring single level spinal fusion.

Detailed Description

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Conditions

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Spinal Fusion Radiculopathy Lumbar Chronic Pain

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Single group
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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DRG Neurostimulation with Spinal Fusion

Group Type EXPERIMENTAL

DRG Neurostimulation with Spinal Fusion

Intervention Type DEVICE

Surgeons will implant a neurostimulator during the same open back procedure as fusion devices (spinal fusion hardware and interbody cage) and begin neurostimulation in a short time following surgery (24 hours).

Interventions

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DRG Neurostimulation with Spinal Fusion

Surgeons will implant a neurostimulator during the same open back procedure as fusion devices (spinal fusion hardware and interbody cage) and begin neurostimulation in a short time following surgery (24 hours).

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Indicated for a single level or two level adjacent spinal fusion having back pain and radiculopathy
* Have been diagnosed with chronic, intractable pain of the lower back and/or leg refractory to conservative therapy for at least 3 of months
* At least 6 months since last surgical procedure on the spine
* Be 21 years of age or older at the time of enrollment
* Be willing and capable of giving informed consent
* Be willing and able to comply with study-related requirements

Exclusion Criteria

* Any prior spinal fusion at index or adjacent level
* Pregnant
* Have a life expectancy of less than 1 year
* Be concomitantly participating in another clinical study
* Be involved in an injury claim under current litigation
* Baseline narcotic use of ≥ 100 MME per day
* Significant untreated addiction to dependency producing medications
* Current active implantable medical device
* Cancer
* Have osteoporosis
* Active infection
* Allergies to system components
* AGE \> 80
* Expected need to undergo MRI imaging in the future
* Other significant comorbidities
Minimum Eligible Age

21 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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SynerFuse, Inc

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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South Bend Orthopaedics

Mishawaka, Indiana, United States

Site Status RECRUITING

University of Minnesota

Minneapolis, Minnesota, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Gabi Molnar

Role: CONTACT

612-217-2914

Facility Contacts

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Derek Yocum, PhD

Role: primary

574-247-9441

Kristin Frenn

Role: primary

Other Identifiers

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G190045

Identifier Type: -

Identifier Source: org_study_id