Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
159 participants
OBSERVATIONAL
2014-12-31
2017-09-13
Brief Summary
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Detailed Description
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This is retrospective case-control study. The data will be analyzed to examine the relationship between exposure to ketamine used as an analgesic agent in combat related trauma care and the expression of psychiatric symptoms measured in the follow-up on the Post Deployment Health Assessment Tool (PDHAT), in use 2003-2007 and the Post Deployment Behavioral Health Assessment (PDBHA), in use 2007 to current date. Coded behavioral health assessment data will be extracted from the research data bank (Protocol IRBnet # 360023, titled "Use of Post Deployment Behavioral Health Assessment Data from Aerovaced Military Admitted to Walter Reed from the Theater of Operations in Iraq and Afghanistan to Establish a Research Data Bank"). This protocol, approved in 2012, has retrospective and prospective components and was designed for studies of this nature. The second objective of this study is to explore demographic and clinical risk factors associated with psychological factors.
Service members who completed the PDHAT or the PDBHA after being AEROVAC-ED from theater for medical care will be grouped according to whether or not they received ketamine for pain before their follow-up assessments. The comparison group for this study will be selected from among those not exposed to ketamine by matching two service members to each in the ketamine group using Injury Severity Scores (ISSs) and Abbreviated Injury Scores (AISs). These scores, originally collected by the US Army Institute of Surgical Research (USAISR) and stored in the Department of Defense Trauma Registry (DoDTR), are an IRB approved addition to the DoP research data bank. WRNMMC and the USAISR have a Memorandum of Understanding allowing use of the scores for research purposes.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Ketamine Group
Active duty military service member injured in theater, AEROVAC-ED out, and received ketamine.
Ketamine
Non-Ketamine Comparison Group
Active duty military service member injured in theater, AEROVAC-ED out, and did NOT receive ketamine treatment for pain.
No interventions assigned to this group
Interventions
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Ketamine
Eligibility Criteria
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Inclusion Criteria
* Active duty military service member injured in theater and treated at WRAMC or at WRNMMC
* 18 years of age or older
* Completed the PBBHA or PDHAT initial and follow up assessment post aerovac from theater
* Received ketamine infusion to treat pain after aero-evacuation for inpatient medical care between Sep 2005 and June 2014
* Received ketamine before completion of the PDHAT or PDBHA follow-up assessment
* ISS scores are available for each individual
Group II. Non-Ketamine Comparison Group
* Active duty military service member injured in theater and treated at WRAMC or at WRNMMC
* 18 years of age or older
* Completed the PBBHA or PDHAT initial and follow up assessment post aerovac from theater
* Did not receive ketamine treatment for pain after aero-evacuation for inpatient medical care before follow-up
* ISS are available for each individual
* Patient will have ISS scores similar to a Ketamine Group patient and a similar timing of injury to the same Ketamine Group patient.
Exclusion Criteria
* Not active duty, activated National Guard, or activated Reserve service members
* Younger than 18 years of age
* Did not complete the PDBHA or PDHAT initial and follow-up assessments
* ISS scores are not available
18 Years
ALL
No
Sponsors
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Defense and Veterans Center for Integrative Pain Management
OTHER
Responsible Party
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Locations
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Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Countries
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Other Identifiers
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380486
Identifier Type: -
Identifier Source: org_study_id
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