Maternal Opioid Treatment: Human Experimental Research - Data Yield Appropriate Decisions

NCT ID: NCT04049799

Last Updated: 2024-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

88 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-08

Study Completion Date

2024-02-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will compare medically-supervised withdrawal (MSW, 'detoxification') to opioid agonist treatment (OAT, 'maintenance') with buprenorphine for pregnant women with opioid use disorder in terms of maternal, fetal, and neonatal outcomes. Outcomes will be assessed during pregnancy, at birth and for 12 months postpartum. This study has the potential to impact health service policy and practices in terms of the treatment options of pregnant women with opioid use disorder.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Some inclusion/exclusion criteria are purposely omitted at this time to preserve scientific integrity. They will be included after the trial is complete.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Opioid-use Disorder Opioid Withdrawal Neonatal Abstinence Syndrome Neonatal Opioid Withdrawal Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Medically-supervised withdrawal (MSW)

Medically-supervised withdrawal

Intervention Type OTHER

6-8 day withdrawal with buprenorphine/naloxone

Comprehensive clinical care

Intervention Type BEHAVIORAL

Obstetrical visits, counseling, case management, psychiatry services, and urine drug screening

Opioid agonist treatment (OAT)

Opioid agonist treatment

Intervention Type OTHER

Induction and maintenance with buprenorphine/naloxone

Comprehensive clinical care

Intervention Type BEHAVIORAL

Obstetrical visits, counseling, case management, psychiatry services, and urine drug screening

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Medically-supervised withdrawal

6-8 day withdrawal with buprenorphine/naloxone

Intervention Type OTHER

Opioid agonist treatment

Induction and maintenance with buprenorphine/naloxone

Intervention Type OTHER

Comprehensive clinical care

Obstetrical visits, counseling, case management, psychiatry services, and urine drug screening

Intervention Type BEHAVIORAL

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Detoxification Maintenance

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Be ages 18 to 41, inclusive
* Have a single fetus pregnancy between 6-30 weeks estimated gestational age
* Willing to participate in the study

Exclusion Criteria

* Non-English speaking
Minimum Eligible Age

18 Years

Maximum Eligible Age

41 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of North Carolina, Chapel Hill

OTHER

Sponsor Role collaborator

Virginia Commonwealth University

OTHER

Sponsor Role collaborator

Mountain Area Health Education Center

UNKNOWN

Sponsor Role collaborator

Johns Hopkins University

OTHER

Sponsor Role collaborator

National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

University of Vermont

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Sarah Heil

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Sarah H Heil, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Vermont

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Mountain Area Health Education Center

Asheville, North Carolina, United States

Site Status

UNC Chapel Hill Horizons

Chapel Hill, North Carolina, United States

Site Status

University of Vermont

Burlington, Vermont, United States

Site Status

Virginia Commonwealth University

Richmond, Virginia, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

R01DA047867

Identifier Type: NIH

Identifier Source: secondary_id

View Link

STUDY00000166

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Tobacco Use in Opioid Agonist Treated Pregnant Women
NCT00497068 COMPLETED PHASE2/PHASE3
Maternal Brain Imaging in Opioid Use Disorder
NCT06008990 ACTIVE_NOT_RECRUITING