Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains
NCT ID: NCT04025138
Last Updated: 2022-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
75 participants
INTERVENTIONAL
2019-07-02
2019-09-01
Brief Summary
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The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that:
* A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that,
* Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race.
According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.
Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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female subjects involved in races over 100 km (F>100)
Female subjects involved in races over 100 km (F\>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.
Neuromuscular tests in isometric mode
Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures :
* Voluntary maximum forces plantar flexors and knee extensors
* Electrically evoked forces
* ElectroMyoGraphic activity (EMG)
* Three-Modality Evoked Potentials (TMEPs)
Transcranial Magnetic Stimulation (TMS)
Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).
Neuromuscular fatigue assessment test
Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.
treadmill
2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.
Blood sample
Blood sample will be realized to measure hemorrheologic and hematologic parameters.
Urinary sample
Urinary sample will be realized to measure hemorrheologic and hematologic parameters.
female subjects involved in races less than 60 km (F<60)
Female subjects involved in races less than 60 km (F\<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.
Neuromuscular tests in isometric mode
Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures :
* Voluntary maximum forces plantar flexors and knee extensors
* Electrically evoked forces
* ElectroMyoGraphic activity (EMG)
* Three-Modality Evoked Potentials (TMEPs)
Transcranial Magnetic Stimulation (TMS)
Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).
Neuromuscular fatigue assessment test
Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.
treadmill
2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.
Blood sample
Blood sample will be realized to measure hemorrheologic and hematologic parameters.
Urinary sample
Urinary sample will be realized to measure hemorrheologic and hematologic parameters.
male subjects involved in races over 100 km (H>100)
Male subjects involved in races over 100 km (H\>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.
Neuromuscular tests in isometric mode
Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures :
* Voluntary maximum forces plantar flexors and knee extensors
* Electrically evoked forces
* ElectroMyoGraphic activity (EMG)
* Three-Modality Evoked Potentials (TMEPs)
Transcranial Magnetic Stimulation (TMS)
Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).
Neuromuscular fatigue assessment test
Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.
treadmill
2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.
Blood sample
Blood sample will be realized to measure hemorrheologic and hematologic parameters.
Urinary sample
Urinary sample will be realized to measure hemorrheologic and hematologic parameters.
male subjects involved in races less than 60 km (H<60)
Male subjects involved in races less than 60 km (H\<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.
Neuromuscular tests in isometric mode
Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures :
* Voluntary maximum forces plantar flexors and knee extensors
* Electrically evoked forces
* ElectroMyoGraphic activity (EMG)
* Three-Modality Evoked Potentials (TMEPs)
Transcranial Magnetic Stimulation (TMS)
Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).
Neuromuscular fatigue assessment test
Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.
treadmill
2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.
Blood sample
Blood sample will be realized to measure hemorrheologic and hematologic parameters.
Urinary sample
Urinary sample will be realized to measure hemorrheologic and hematologic parameters.
Interventions
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Neuromuscular tests in isometric mode
Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures :
* Voluntary maximum forces plantar flexors and knee extensors
* Electrically evoked forces
* ElectroMyoGraphic activity (EMG)
* Three-Modality Evoked Potentials (TMEPs)
Transcranial Magnetic Stimulation (TMS)
Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).
Neuromuscular fatigue assessment test
Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.
treadmill
2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.
Blood sample
Blood sample will be realized to measure hemorrheologic and hematologic parameters.
Urinary sample
Urinary sample will be realized to measure hemorrheologic and hematologic parameters.
Eligibility Criteria
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Inclusion Criteria
* Affiliates or beneficiaries of social security scheme
* Signed consent
Exclusion Criteria
* Pregnant woman
* Chronic joint diseases
* Chronic or central neurological pathologies
* Taking neuroactive substances that can alter corticospinal excitability
* Contraindication to experimental procedures including Transcranial Magnetic Stimulation (TMS)
* Taking corticosteroids in the previous 3 months
18 Years
ALL
Yes
Sponsors
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Centre Hospitalier Universitaire de Saint Etienne
OTHER
Responsible Party
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Principal Investigators
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Léonard FEASSON, MD PhD
Role: PRINCIPAL_INVESTIGATOR
CHU SAINT-ETIENNE
Guillaume MILLET, PhD
Role: STUDY_DIRECTOR
University of Saint-Etienne
Locations
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CHU Saint-Etienne
Saint-Etienne, , France
Countries
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References
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Robert M, Stauffer E, Nader E, Skinner S, Boisson C, Cibiel A, Feasson L, Renoux C, Robach P, Joly P, Millet GY, Connes P. Impact of Trail Running Races on Blood Viscosity and Its Determinants: Effects of Distance. Int J Mol Sci. 2020 Nov 12;21(22):8531. doi: 10.3390/ijms21228531.
Temesi J, Besson T, Parent A, Singh B, Martin V, Brownstein CG, Espeit L, Royer N, Rimaud D, Lapole T, Feasson L, Millet GY. Effect of race distance on performance fatigability in male trail and ultra-trail runners. Scand J Med Sci Sports. 2021 Sep;31(9):1809-1821. doi: 10.1111/sms.14004. Epub 2021 Jul 12.
Foure A, Besson T, Stauffer E, Skinner SC, Bouvier J, Feasson L, Connes P, Hautier CA, Millet GY. Sex-related differences and effects of short and long trail running races on resting muscle-tendon mechanical properties. Scand J Med Sci Sports. 2022 Oct;32(10):1477-1492. doi: 10.1111/sms.14203. Epub 2022 Jul 6.
Pastor FS, Besson T, Varesco G, Parent A, Fanget M, Koral J, Foschia C, Rupp T, Rimaud D, Feasson L, Millet GY. Performance Determinants in Trail-Running Races of Different Distances. Int J Sports Physiol Perform. 2022 Jun 1;17(6):844-851. doi: 10.1123/ijspp.2021-0362. Epub 2022 Feb 25.
Sabater Pastor F, Varesco G, Besson T, Koral J, Feasson L, Millet GY. Degradation of energy cost with fatigue induced by trail running: effect of distance. Eur J Appl Physiol. 2021 Jun;121(6):1665-1675. doi: 10.1007/s00421-021-04624-5. Epub 2021 Mar 5.
Trama R, Blache Y, Hintzy F, Rossi J, Millet GY, Hautier C. Does neuromuscular fatigue generated by trail running modify foot-ground impact and soft tissue vibrations? Eur J Sport Sci. 2023 Jul;23(7):1155-1163. doi: 10.1080/17461391.2022.2093649. Epub 2022 Jul 10.
Besson T, Parent A, Brownstein CG, Espeit L, Lapole T, Martin V, Royer N, Rimaud D, Sabater Pastor F, Singh B, Varesco G, Rossi J, Temesi J, Millet GY. Sex Differences in Neuromuscular Fatigue and Changes in Cost of Running after Mountain Trail Races of Various Distances. Med Sci Sports Exerc. 2021 Nov 1;53(11):2374-2387. doi: 10.1249/MSS.0000000000002719.
Other Identifiers
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2019-A00736-51
Identifier Type: OTHER
Identifier Source: secondary_id
19CH060
Identifier Type: -
Identifier Source: org_study_id