Optimal Positive End-expiratory Pressure (PEEP) in Prone Position During Spine Surgery
NCT ID: NCT04024410
Last Updated: 2021-10-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
20 participants
OBSERVATIONAL
2019-06-03
2021-02-22
Brief Summary
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There is a lack of studies regarding Optimal (best) positive end-expiratory pressure (PEEP) in prone position during surgery, and its relation with optimal PEEP in supine position.
Hypothesis:
In patients undergoing scheduled spinal surgery, optimal PEEP in the prone position is lower than optimal PEEP in the supine position.
Aims:
To assess the difference optimal PEEP in supine vs. prone positions in patients undergoing spine surgery.
To evaluate the changes in optimal PEEP in prone position throughout the surgical procedure.
Methods:
Observational study, one center. Main variable: optimal PEEP. Secondary variables: PaO2, pCO2 and dynamic compliance (Crd) in prone and supine position.
Detailed Description
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Secondary outcomes: Pulmonary compliance, blood gas analysis and hemodynamic parameters
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Evaluation of PEEP in prone position
Assessment of optimal Positive End-Expiratory Pressure (PEEP) in patients undergoing scheduled spine surgery in prone position.
Eligibility Criteria
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Inclusion Criteria
* Spine prone surgery lasting ≥2 hours.
* Absence of known pulmonary pathology.
Exclusion Criteria
* Contraindication to alveolar recruitment maneuvers (risk of barotrauma, hemodynamic instability).
* Body mass index (BMI) \>35.
* Heart failure defined as IC \<2.5 L/min/m2 and/or inotropic support requirements prior to surgery.
* Diagnosis or suspicion of intracranial hypertension (intracranial pressure \>15 mmHg).
18 Years
ALL
No
Sponsors
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Parc de Salut Mar
OTHER
Responsible Party
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Principal Investigators
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Lluís Gallart, Dr
Role: PRINCIPAL_INVESTIGATOR
Hospital del Mar (Barcelona, Spain)
Locations
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Hospital del Mar
Barcelona, , Spain
Countries
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References
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Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS, Talmor D, Thompson BT, Wunsch H, Uleryk E, Brozek J, Brochard LJ; American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine. An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263. doi: 10.1164/rccm.201703-0548ST.
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Other Identifiers
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2018/8270/I
Identifier Type: -
Identifier Source: org_study_id