Diary-based Study on the Course of Hormone-withdrawal Migraines

NCT ID: NCT04012593

Last Updated: 2021-04-30

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 47 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-01-31
• Study Completion Date: 2019-08-31

Brief Summary

Single centered diary-based study to identify course and characteristics of hormone withdrawal headaches/migraines in users of combined hormonal contraceptives Objectives of the Research Project: to identify the course and characteristics of hormone withdrawal headaches/migraines in users of combined hormonal contraceptives (CHC)

Detailed Description

Participant recruitment is performed through advertisement placed in University Zürich (USZ) online. Advertisement in offices of neurologists and headache specialists, homepage of the Swiss headache society.

Interested women contact the investigators via email and are called back by one of the study doctors or students within 1 day from Monday-Friday. This phone call is thought to inform the women about the study in more detail and for the investigators to check eligibility. During this call the participants are informed about the study procedure and can ask any question. Here most important points are use of a CHC in a 21/7 regimen, regular (at least once on two months) withdrawal migraine/headaches, intention to continue the use of the contraceptive for 3 more months.

If the participants decide to participate, inclusion and exclusion criteria are checked. If women are applicable they receive the consent form and the study information with an envelope for return. If more questions come up the investigators are available per email and phone for answers. If a patient doesn't return the consent form the investigator will delete the personal data, which collected before. Only the year of birth will be noted in the personal data.

After consent participants receive headaches diaries (with mail /post) and a prepaid envelope (for return). Participants are also offered the option to return their diaries electronically via email to the study doctor. Furthermore participants receive in a second phone contact instructions, how to fill in the headache diary and the day of study start (first day of the next pill package).

Headache diaries should be returned monthly (per email or post) and are conducted for 3 pill cycles.

If complete headache diaries are not returned participants will be contacted per email after 1 week to remind the participants. If this email is not being answered within another week a phone contact will take place to identify potential reasons for noncompliance or withdrawal of consent or drop out.

Observation period 3 pill cycles : 3 times 28 days

Outcomes of the Research Project:

• Daily number of headaches and migraine in each day of the observation cycle.and during the Hormone-free interval (HFI)
• First day of migraine in the pill-free interval
• Start of migraine in relation to withdrawal bleeding
• Start of and number of prolonged migraines >24 hours in the pill-free interval and the phase of hormone intake.
• Pain intensity in the pill-free interval in comparison to the pill-phase
• Number of rescue medications/ migraine day during HFI and during pill intake
• efficacy of the medications (did medication stop the attack and did the attack return after maximal 8 hours)
• Within patient variability of the first migraine day in the HFI.

Statistical Methodology:

• Primary and secondary endpoints will be calculated as frequencies and percentages.
• For comparison the number of prolonged attacks during pill use and the HFI prolonged attacks per day of the observation interval are calculated and thereafter chi-square test for comparisons is used .
• Software programme is used for data analyses.

Conditions

Migraine

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

premenopausal women

diary

Diary

Intervention Type: BEHAVIORAL

Interventions

Diary

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Premenopausal women
• Age 18-50 years
• Use of combined hormonal contraceptives 21/7 regimen
• Suffering from headache/migraine in the HFI.
• Women are allowed to use their normal headache medications

Exclusion Criteria

• Withdrawal of consent
• incomplete diaries
• pregnancy
• migraine/headache in only 1 cycle
• inability to follow procedures (e.g. due to psychological disorders or dementia), insufficient knowledge of project language).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Gabriele Merki, Professor

Role: STUDY_DIRECTOR

University Hospital, Zürich

Locations

Universitätsspital Zürich

Zurich, , Switzerland

Countries

Switzerland

Other Identifiers

2016-01791

Identifier Type: -

Identifier Source: org_study_id