Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples
NCT ID: NCT04011228
Last Updated: 2019-09-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
224 participants
OBSERVATIONAL
2016-02-29
2020-01-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Type 2 diabetic patients
Blood sampling
After a fasting period over night blood samples will be taken.
Saliva and blood samples
After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.
Magnet Resonance Spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.
Prediabetic patients
Blood sampling
After a fasting period over night blood samples will be taken.
Saliva and blood samples
After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.
Magnet Resonance Spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.
Women with gestational diabetes
Blood sampling
After a fasting period over night blood samples will be taken.
Saliva and blood samples
After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.
Magnet Resonance Spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.
Healthy control subjects
Blood sampling
After a fasting period over night blood samples will be taken.
Saliva and blood samples
After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.
Magnet Resonance Spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.
Pregnant women without gestational diabetes
Blood sampling
After a fasting period over night blood samples will be taken.
Saliva and blood samples
After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.
Magnet Resonance Spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.
Interventions
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Blood sampling
After a fasting period over night blood samples will be taken.
Saliva and blood samples
After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications.
Magnet Resonance Spectroscopy
The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy.
Eligibility Criteria
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Inclusion Criteria
* prediabetic patients
* women with gestational diabetes
* healthy control subjects without diabetes
* healthy pregnant women
Exclusion Criteria
* infectious diseases such as hepatitis or HIV
* malignoms
* patients with claustrophoby
18 Years
75 Years
ALL
No
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Alexandra Kautzky-Willer
Principal Investigator
Principal Investigators
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Alexandra Kautzky-Willer, Univ.Prof.Dr.
Role: PRINCIPAL_INVESTIGATOR
Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna
Locations
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Medical University of Vienna
Vienna, , Austria
Countries
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Central Contacts
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Facility Contacts
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References
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Klepochova R, Leutner M, Bastian M, Krebs M, Weber M, Trattnig S, Kautzky-Willer A, Krssak M. Muscle-Specific Relation of Acetylcarnitine and Intramyocellular Lipids to Chronic Hyperglycemia: A Pilot 3-T 1H MRS Study. Obesity (Silver Spring). 2020 Aug;28(8):1405-1411. doi: 10.1002/oby.22846.
Other Identifiers
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EPI-1090
Identifier Type: -
Identifier Source: org_study_id
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