Randomized Study Regarding Preventive Jaw- and Swallowing Intervention for Patients with Head and Neck Cancer

NCT ID: NCT04005521

Last Updated: 2024-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-06-13

Study Completion Date

2028-07-31

Brief Summary

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The study includes patients with tumors of the oropharynx, larynx and hypopharynx scheduled to receive radiotherapy with curative intent (+/- chemotherapy). The patients will be randomized into either an intervention group (performing a preventive jaw- and swallowing exercise protocol before and during radiotherapy) or a control group no performing a exercise protocol. All patients will be encouraged to eat or drink for as long as possible during the therapy. All patients will meet with a speech-language therapist weekly during radiotherapy.

Detailed Description

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Conditions

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Head and Neck Neoplasm Trismus Deglutition Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Preventive intervention

Patient will perform daily exercise: jaw and swallwing exercises, as well as are encouraged to eat and drink for as long as possible during treatment

Group Type EXPERIMENTAL

Preventive intervention

Intervention Type BEHAVIORAL

Preventive, structured exercise protocol

Control group

No intervention, only encouragement to eat and drink for as long as possible during treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Preventive intervention

Preventive, structured exercise protocol

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Head and neck cancer (tumors of the oropharynx, pharynx, hypopharynx and larynx)
* Receiving radiohterpay (+/- chemotherapy) with curative intent
* No previous trismus or dysphagia

Exclusion Criteria

* Surgery due to head and neck cancer
* Previous treatment for head and neck cancer
* Tracheostomized patients
* No teeth
* Inability to perform exercise intervention
* Inability to independently fill out questionnaires in Swedish
* Previous neurologic or neuromuscular disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sahlgrenska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Lisa Tuomi

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status

Countries

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Sweden

References

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Saghafi E, Kadhim K, Andas CA, Cahlin BJ, Finizia C, Axelsson T, Kjeller G, Tuomi L. Jaw exercise in head and neck cancer patients for prevention of temporomandibular disorders: a randomized controlled trial. J Cancer Surviv. 2024 Nov 22. doi: 10.1007/s11764-024-01717-w. Online ahead of print.

Reference Type BACKGROUND
PMID: 39576571 (View on PubMed)

Petersson K, Finizia C, Pauli N, Tuomi L. Preventing radiation-induced dysphagia and trismus in head and neck cancer-A randomized controlled trial. Head Neck. 2025 Jan;47(1):159-174. doi: 10.1002/hed.27886. Epub 2024 Aug 1.

Reference Type BACKGROUND
PMID: 39091121 (View on PubMed)

Other Identifiers

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Identifier Type: -

Identifier Source: org_study_id