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Effects of a Multiple Component Training Program on Muscles in Adults With Myotonic Dystrophy Type 1

NCT ID: NCT04001920

Last Updated: 2019-06-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-23

Study Completion Date

2013-12-13

Brief Summary

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A strength and endurance training program was conducted in adults with myotonic dystrophy type 1 (DM1). Participants underwent a 12-week/18-session supervised training program consisted of 6 exercises: elbow flexion/extension, shoulder horizontal adduction, leg press, and knee flexion/extension. To offer a complete training program aimed at improving function it was divided: the first 6 weeks were dedicated to strength-training, whereas the following weeks focused on endurance-training. To evaluate the effects of the training program, participants completed maximal strength, endurance and functional evaluations. Volunteers could also add a muscle biopsy at the beginning and the end of the program to evaluate physiological parameters.

Detailed Description

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Conditions

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Myotonic Dystrophy 1

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Training program

12-week strength and endurance training program

Group Type EXPERIMENTAL

Training program

Intervention Type OTHER

12-week, 18-session training program. To offer a complete training program aimed at improving function it was divided : the first 6 weeks were dedicated to strength-training (2 sets of 6 repetitions at 80% of 1-RM), whereas the following weeks focused on endurance-training (1 set of 25 repetitions at 40% of 1-RM).

Interventions

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Training program

12-week, 18-session training program. To offer a complete training program aimed at improving function it was divided : the first 6 weeks were dedicated to strength-training (2 sets of 6 repetitions at 80% of 1-RM), whereas the following weeks focused on endurance-training (1 set of 25 repetitions at 40% of 1-RM).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults with DM1
* Walk without technical aid
* Muscle impairment rating scale (MIRS) of 3 or 4

Exclusion Criteria

* Severe musculoskeletal disorders
* Any medical contraindication to physical exercise
* Any medical contraindication to muscle biopsies for the biopsy volunteers
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondation du Grand défi Pierre Lavoie

UNKNOWN

Sponsor Role collaborator

Cynthia Gagnon

OTHER

Sponsor Role lead

Responsible Party

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Cynthia Gagnon

Sponsor-Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Cynthia Gagnon, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Université de Sherbrooke

Locations

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Groupe de recherche interdisciplinaire sur les maladies neuromusculaires

Saguenay, Quebec, Canada

Site Status

Countries

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Canada

References

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Roussel MP, Morin M, Girardin M, Fortin AM, Leone M, Mathieu J, Gagnon C, Duchesne E. Training program-induced skeletal muscle adaptations in two men with myotonic dystrophy type 1. BMC Res Notes. 2019 Aug 20;12(1):526. doi: 10.1186/s13104-019-4554-z.

Reference Type DERIVED
PMID: 31429798 (View on PubMed)

Other Identifiers

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2013-008

Identifier Type: -

Identifier Source: org_study_id