Accelerated Theta Burst in Chronic Pain: A Biomarker Study

NCT ID: NCT03984201

Last Updated: 2024-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-01

Study Completion Date

2024-08-01

Brief Summary

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This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for chronic pain. In this double blind, randomized control study, participants will be randomized to the treatment group to receive accelerated theta-burst stimulation or to a control group. All participants will be offered the open-label, active treatment 4 week prior to completing the initial 5 days of treatment.

Detailed Description

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Repetitive transcranial magnetic stimulation (rTMS) is an established technology as therapy for treatment-resistant depression and has been utilized to treat persons suffering from chronic pain. The approved method for treatment is 10Hz stimulation for 40 min over the left dorsolateral prefrontal cortex (L-DLPFC). This methodology has been very successful in real world situations. The limitations of this approach include the duration of the treatment (approximately 40 minutes per treatment session). Recently, researchers have aggressively pursued modifying the treatment parameters to reduce treatment times with some preliminary success. This study intends to further modify the parameters to create a more rapid form of the treatment and look at the change in neuroimaging biomarkers.

Conditions

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Chronic Pain

Keywords

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Chronic Pain Repetitive Transcranial Magnetic Stimulation (rTMS) Accelerated Theta Burst Stimulation (aTBS) Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinded, randomized control
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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iTBS over L-DLPFC to dACC

Participants will receive iTBS (intermittent theta burst stimulation) to the left dorsal lateral prefrontal cortex (L-DLPFC) with high connectivity to the dorsal anterior cingulate cortex (dACC). The L-DLPFC will be targeted utilizing the Localite neuronavigation system. Stimulation intensity will be standardized at 90% of resting motor threshold adjust to the skull to cortical surface distance.

Stimulation will be delivered to L-DLPFC using the MagPRo stimulator.

Group Type ACTIVE_COMPARATOR

Intermittent Theta Burst Stimulation (iTBS)

Intervention Type DEVICE

Participants will receive active or sham transcranial magnetic stimulation delivered to the L-DLPFC.

iTBS over L-DLPFC to sgACC

Participants will receive iTBS (intermittent theta burst stimulation) to the left dorsal lateral prefrontal cortex (L-DLPFC) with high connectivity to the subgenual cingulate cortex (sgACC). The L-DLPFC will be targeted utilizing the Localite neuronavigation system. Stimulation intensity will be standardized at 90% of resting motor threshold adjust to the skull to cortical surface distance.

Stimulation will be delivered to L-DLPFC using the MagPRo stimulator.

Group Type ACTIVE_COMPARATOR

Intermittent Theta Burst Stimulation (iTBS)

Intervention Type DEVICE

Participants will receive active or sham transcranial magnetic stimulation delivered to the L-DLPFC.

Sham iTBS over L-DLPFC

Participants will receive sham iTBS (intermittent theta burst stimulation) to the left DLPFC. The L-DLPFC will be targeted utilizing the Localite neuronavigation system.

Sham stimulation will be delivered to L-DLPFC using the MagPRo stimulator.

Group Type SHAM_COMPARATOR

Intermittent Theta Burst Stimulation (iTBS)

Intervention Type DEVICE

Participants will receive active or sham transcranial magnetic stimulation delivered to the L-DLPFC.

Interventions

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Intermittent Theta Burst Stimulation (iTBS)

Participants will receive active or sham transcranial magnetic stimulation delivered to the L-DLPFC.

Intervention Type DEVICE

Other Intervention Names

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Accelerated Theta Burst Stimulation (aTBS) Repetitive Transcranial Magnetic Stimulation (rTMS)

Eligibility Criteria

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Inclusion Criteria

1. Patients need to meet at least a 4/10 on a clinical pain rating scale and/or fulfill fibromyalgia diagnostic criteria on the 2010 Fibromyalgia Diagnostic Criteria (Wolfe et al., 2010)
2. Age 18 - 70
3. Right-handed
4. Agree to having fMRI scans as well as rTMS sessions
5. Proficiency in English sufficient to complete questionnaires / follow instructions during fMRI assessments and treatment
6. Women of childbearing potential must agree to use adequate contraception prior to study entry and continue this for the duration of the study
7. Participants may continue antidepressant regimen, but must be stable for 6 weeks prior to enrollment in the study. Antidepressant must be of the SSRI class only (if currently on a different antidepressant, patients will be switched to an SSRI). They must maintain that same antidepressant regimen throughout the study duration.

Exclusion Criteria

1. History of MI, CABG, CHF, or other cardiac history.
2. Any condition that would contraindicate MRI (such as ferromagnetic metal in the body)
3. Pregnancy or breastfeeding
4. Any neurological condition, history of epilepsy, history of rTMS failure with FDA approved rTMS parameters, history of any implanted device or psychosurgery for depression, history of receiving ECT. OCD, narcolepsy or any additional significant neurological disorder as determined by the PI.
5. Autism spectrum disorder
6. Inability to stop taking medication contraindicated with treatment
7. Any significant psychiatric disorder as identified on the Mini International Neuropsychiatric Interview and determined by the PI
8. A positive urine toxicology screen
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Nolan R

Assistant Professor of Psychiatry and Behavioral Sciences

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Stanford University

Palo Alto, California, United States

Site Status

Countries

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United States

References

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Other Identifiers

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48366

Identifier Type: -

Identifier Source: org_study_id