Medical and Surgical Management of Patients With Brain Metastases
NCT ID: NCT03981016
Last Updated: 2020-10-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
105 participants
INTERVENTIONAL
2015-03-02
2020-08-31
Brief Summary
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Detailed Description
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Every histological or biological profile requires a specific evaluation, and management. Clinical trials are the reference to establish the efficacy and the toxicity of the new processes, but usually answer only at a single question and for very selected patients.
For this reason, the SIRIC Montpellier Cancer proposes to develop a prospective and regional Clinical Database Project and regional biological collection (blood and tumor samples), which is an expanding data collection designed to contribute to a better understand the patient's management with brain metastases including quality of life and neuropsychological/cognitive aspects.
Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Biological collection
For the patients include in the study :
* blood samples collected at different times : Before surgery and during the post-operative visit and
* frozen tumor samples and / or paraffin samples at the time of surgery and- paraffin around tumor samples at the time of surgery
Biological collection
* blood samples collected at different times : Before surgery and during the post-operative visit and
* frozen tumor samples and / or paraffin samples at the time of surgery and- paraffin around tumor samples at the time of surgery
Interventions
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Biological collection
* blood samples collected at different times : Before surgery and during the post-operative visit and
* frozen tumor samples and / or paraffin samples at the time of surgery and- paraffin around tumor samples at the time of surgery
Eligibility Criteria
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Inclusion Criteria
2. Radiological diagnosis of brain metastases
3. Patient eligible for neurosurgical exeresis or treatment by radio-surgery
4. Patient treated in a neurosurgery center of the Languedoc-Roussillon region (whatever therapeutic treatment realized on primary tumor)
5. Present brain metastases not previously treated
6. Signed informed consent
7. Patient affiliated to a national insurance system or beneficiary of such a system
Exclusion Criteria
2. Impossibility to be regularly monitored for psychological, family, social, or geographical reasons
3. Subject under guardianship
18 Years
ALL
No
Sponsors
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Institut du Cancer de Montpellier - Val d'Aurelle
OTHER
Responsible Party
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Principal Investigators
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Luc Bauchet, MD
Role: PRINCIPAL_INVESTIGATOR
Centre hospitalier de Montpellier
Locations
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Centre hospitalier régional et universitaire de Nîmes
Nîmes, Gard, France
Centre médical Oncogard
Nîmes, Gard, France
Clinique les Franciscaines
Nîmes, Gard, France
Laboratoire d'anatomo-pathologie de Nîmes
Nîmes, Gard, France
Centre médical Oncodoc Béziers
Béziers, Hérault, France
Centre d'Anatomie et Cytologie Pathologiques de Grabels
Grabels, Hérault, France
Centre hospitalier régional et universitaire de Montpellier
Montpellier, Hérault, France
Clinique Clémentville
Montpellier, Hérault, France
Clinique du Millénaire
Montpellier, Hérault, France
Institut régional du cancer
Montpellier, Hérault, France
Centre hospitalier de Perpignan
Perpignan, Pyrénées-orientales, France
Clinique Saint-Pierre
Perpignan, Pyrénées-orientales, France
Countries
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References
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Davis FG, Dolecek TA, McCarthy BJ, Villano JL. Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data. Neuro Oncol. 2012 Sep;14(9):1171-7. doi: 10.1093/neuonc/nos152. Epub 2012 Aug 16.
Fox BD, Cheung VJ, Patel AJ, Suki D, Rao G. Epidemiology of metastatic brain tumors. Neurosurg Clin N Am. 2011 Jan;22(1):1-6, v. doi: 10.1016/j.nec.2010.08.007.
Smedby KE, Brandt L, Backlund ML, Blomqvist P. Brain metastases admissions in Sweden between 1987 and 2006. Br J Cancer. 2009 Dec 1;101(11):1919-24. doi: 10.1038/sj.bjc.6605373. Epub 2009 Oct 13.
Kocher M, Soffietti R, Abacioglu U, Villa S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, Ben Hassel M, Kouri M, Valeinis E, van den Berge D, Collette S, Collette L, Mueller RP. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol. 2011 Jan 10;29(2):134-41. doi: 10.1200/JCO.2010.30.1655. Epub 2010 Nov 1.
Other Identifiers
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ICM-URC-2014/21
Identifier Type: -
Identifier Source: org_study_id
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