The Effect of Arsenic Trioxide on Eliminating HIV-1 Reservoir Combined With cART

NCT ID: NCT03980665

Last Updated: 2022-09-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-01

Study Completion Date

2025-12-31

Brief Summary

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To evaluate the safety and efficacy of arsenic trioxide combined with cART in eliminating latent HIV-1 reservoir, providing potential strategies for AIDS functional cure.

Detailed Description

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Although combined antiretroviral therapy (cART) could control human immunodeficiency virus type 1 (HIV-1) infection, the persistence of HIV-1 viral reservoir make it extremely difficult to achieving cure of AIDS. The shock and kill strategy has been extensively practiced. The latency reversing agents (LRAs) could reactivate latent HIV-1 and then the reactivated virus could be eradicated. However, no appropriate activator has been found nor manufactured. Our previous work found that the arsenic trioxide, clinically approved for treating acute promyelocytic leukemia,could efficiently reactivate latent provirus in CD4+T cells from HIV-1 patients and Simian immunodeficiency virus (SIV)-infected macaques, without significant systemic T cell activation and inflammatory responses. In this study, we are going to study the safety of and efficacy of arsenic trioxide combined with cART in 20 HIV-1 infected patients, by observing adverse events,HIV-1 reservoir, HIV-1 load, and some immune index.

Conditions

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HIV/AIDS

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The control arm includes HIV-infected patients with the therapy of Antiretroviral drugs.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arsenic trioxide combined with cART

Receiving intravenous arsenic trioxide, 0.16mg/kg/day, no more than 10 mg per-day , two to four weeks, combined with continuous cART after attaining plasma HIV-1 suppression (plasma HIV RNA \<50 cp/ml) and CD4+ cell count more than 350 cells/ul over 1 year by cART, without active HCV or HBV infection or opportunistic infections.

Group Type EXPERIMENTAL

Arsenic Trioxide

Intervention Type DRUG

a arsenic class of mineral, clinically approved for treating acute promyelocytic leukemia

Without arsenic trioxide therapy

Only receiving cART without arsenic Trioxide after attaining plasma HIV-1 suppression (plasma HIV RNA \<50 cp/ml) and CD4+ cell count more than 350 cells/ul over 1 year by cART, without active HCV or HBV infection or opportunistic infections.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Arsenic Trioxide

a arsenic class of mineral, clinically approved for treating acute promyelocytic leukemia

Intervention Type DRUG

Other Intervention Names

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Arsenic Trioxide Injectable Solution

Eligibility Criteria

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Inclusion Criteria

1. HIV infection confirmed
2. Receiving HAART more than 12 months.
3. HIV viral-load \< 50 copies/ml and CD4+ cell count more than 350 cells/ul.
4. Without serious heart, lung, liver or kidney disease.
5. Participants know about the study and sign informed consent.

Exclusion Criteria

1. With serious active HBV or HCV infection or opportunistic infections
2. With serious chronic disease such as diabetes, mental illness,et al
3. History of suffering from pancreatitis during HAART.
4. Pregnant or breast-fed.
5. With poor adherence.
6. Unable to complete the follow up.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences

UNKNOWN

Sponsor Role collaborator

Guangzhou 8th People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Linghua LI

Vice Chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Weiping Cai, Bachelor

Role: STUDY_CHAIR

Guangzhou 8th People's Hospital

Locations

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Guangzhou 8th People's Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Linghua Li, Doctor

Role: CONTACT

020-83710825

Weiping Cai, Bachelor

Role: CONTACT

020-83710816

Facility Contacts

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Linghua LI, PhD

Role: primary

020-83710825

C

Role: backup

References

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Other Identifiers

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20170812V1

Identifier Type: -

Identifier Source: org_study_id

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