Hypothermia Risk With Continuous Renal Replacement Therapy

NCT ID: NCT03973814

Last Updated: 2023-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-01

Study Completion Date

2023-12-21

Brief Summary

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The present study aims at testing if the TherMax blood warmer is more accurate and reliable in reaching and maintaining chosen target temperature during continuous renal replacement therapy as compared to the Prismaflo IIS blood warmer used for the PrismaFlex system.

Detailed Description

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Blood warming devices during continuous renal replacement therapy (CRRT) have not been adequately tested.

The novel TherMax blood warmer for the newly introduced PrisMax System heats blood and replacement solutions via a dry heat plate system. In contrast, the PRISMAFLO IIS Blood Warmer for PRISMAFLEX System uses an electric heating sleeve on a standard CRRT filter set.

Data on adverse events (AE) during continuous renal replacement therapy (CRRT) has been studied and one of the most common AE was hypothermia, reported in 44% of all cases.

The present study aims at testing if the TherMax blood warmer is more accurate and reliable in reaching and maintaining chosen target temperature during CRRT as compared to the blood warmer used for the PrismaFlex system.

Conditions

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Acute Kidney Injury Hypothermia

Keywords

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continuous renal replacement therapy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SEQUENTIAL

The investigators will assess body temperature before-, during- and after Thermax blood warming treatment. Patients are essentially their own controls.

Moreover, we will use historic data on the previous blood warmer for the Prismaflex device to assess temperature changes.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Prior to Thermax Warming

Baseline temperature

Group Type ACTIVE_COMPARATOR

Thermax Blood Warmer

Intervention Type DEVICE

Patients will be their own controls: Prior to-, during-, and after Thermax blood warming.

During warming

Temperature during Thermax warming

Group Type ACTIVE_COMPARATOR

Thermax Blood Warmer

Intervention Type DEVICE

Patients will be their own controls: Prior to-, during-, and after Thermax blood warming.

Post warming

Temperature after cessation of Thermax warming

Group Type ACTIVE_COMPARATOR

Thermax Blood Warmer

Intervention Type DEVICE

Patients will be their own controls: Prior to-, during-, and after Thermax blood warming.

Interventions

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Thermax Blood Warmer

Patients will be their own controls: Prior to-, during-, and after Thermax blood warming.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adult (18-100 years) critically ill patients treated with CRRT.

Exclusion Criteria

* Patients under 18 years of age. Non-RRT patients.
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Skane University Hospital

OTHER

Sponsor Role collaborator

Karolinska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Max Bell

MD, PhD, Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Max Bell, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Karolinska University Hospital

Marcus Broman, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Skane University Hospital

Locations

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Karolinska University Hospital

Stockholm, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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BxIIRgrant

Identifier Type: -

Identifier Source: org_study_id