Ondansetron in the Prevention of Hypotension in Patients Undergoing Spinal Anesthesia

NCT ID: NCT03973411

Last Updated: 2019-06-04

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE4
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-03-01
• Study Completion Date: 2020-03-31

Brief Summary

Ondansetron, a potent 5-HT 3 receptor antagonist commonly used as an antiemetic. The main objective of the present study is to verify the hypothesis that blocking type 3 serotonin receptors with intravenous ondansetron reduces the incidence of spinal anesthesia-induced hypotension

Detailed Description

Spinal anesthesia is usually the first choice for many surgical procedures of lower limbs, perineum, and lower abdomen. It is a simple and safe procedure, however it can present complications such as hypotension and bradycardia.

Hypotension results mainly from a decrease in systemic vascular resistance secondary to a blockage of sympathetic fibers. The Bezold-Jarisch reflex, proposed as a mechanism for bradycardia is mediated by serotonin receptors (subtype 5-HT3) located in the vagus nerve and within the walls of the cardiac ventricles. 5-HT3 receptors are activated in response to systemic hypotension, causing increased vagal efferent signaling, bradycardia, reduced cardiac output and increased exacerbation of hypotension.

Therefore, ondansetron, a potent 5-HT 3 receptor antagonist commonly used as an antiemetic, is potentially useful in attenuating this response. To assess this response, the main goal of the present study is to verify the hypothesis that blocking type 3 serotonin receptors with intravenous ondansetron reduces the incidence of spinal anesthesia-induced hypotension.

This prospective, randomized, double-blind, placebo-controlled study aims to verify the hypothesis that blocking serotonin type 3 receptors with intravenous ondansetron prior to subarachnoid block reduces hypotension induced by spinal anesthesia in surgical procedures at Base Hospital of the Federal District. The examiners responsible for patient assessment will not have access to the agents used.

Patients will be randomized through a randomly generated list. The examiner responsible for opening the envelope will make the draw, will include the patient in one of the groups, write down their data in the random list, prepare the syringe with the medication, and deliver it to the operating room so that the next examiners will not be aware of the administered drug.

Patients will receive standard monitoring, venoclysis, intravenous midazolam as pre-anesthetic medication. The study drug (ondansetron 0.15 mg / kg or placebo) will then be administered. All patients received spinal anesthesia with hyperbaric bupivacaine and opioid adjuvants at the discretion of the anesthesiologist.

The evolution of vital signs such as systolic blood pressure, mean heart rate, height of the sensitive block, incidence of adverse events such as bradycardia, tachycardia, hypertension or hypotension, nausea, vomiting, vasopressor and antiemetic consumption will be evaluated.

Conditions

Hypotension

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

Ondansetron group

Patients will receive intravenous ondansetron before spinal anesthesia

Group Type: ACTIVE_COMPARATOR

Prophylactic ondansetron

Intervention Type: DRUG

Pacients will receibe prophylactic ondansetron plus standard spinal anesthesia

Control group

Patients will receive intravenous saline before spinal anesthesia

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Pacients will receibe standard spinal anesthesia

Interventions

Prophylactic ondansetron

Pacients will receibe prophylactic ondansetron plus standard spinal anesthesia

Intervention Type: DRUG

Placebo

Pacients will receibe standard spinal anesthesia

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Patients aged between 18 and 70 years, electively scaled for surgery requiring neuraxial block, with programming of spinal anesthesia.
• Physical State 1, 2 or 3 of the American Society of Anesthesiology (ASA)

Exclusion Criteria

• Patients taking prophylactic or therapeutic anticoagulation, except respecting the allowed range;
• Patients with atrioventricular block
• Patients with cardiac arrhythmias
• Patients with heart failure;
• Patients with renal disease
• Patients with liver disease
• Patient carrying or suspecting any type of systemic infection or located in a puncture site;
• Patients who refuse to participate in the study after presenting the free and informed consent form;

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hospital de Base

OTHER

Sponsor Role: lead

Responsible Party

Fabricio Tavares Mendonca

Preceptor of medical residency in anesthesiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Fabricio T Mendonça, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital de Base do Distrito Federal

Locations

Hospital de Base do Distrito Federal

Brasília, Federal District, Brazil

Site Status: RECRUITING

Countries

Brazil

Central Contacts

Fabricio T Mendonça, MD

Role: CONTACT

correiodofabricio@gmail.com

5561981882640

Facility Contacts

Jamil Elias, MD

Role: primary

uamphbdf@gmail.com

556133151588

Viviane Rezende, MD

Role: backup

vrezende@icab.med.br

556133151331

Other Identifiers

Ondansetron for spinal

Identifier Type: -

Identifier Source: org_study_id