Trial Outcomes & Findings for Optimizing HPV Vaccine Introduction in Shanghai, China (NCT NCT03972813)

Last Updated: 2025-01-15

Results Overview

Immediately after the experimental component, parents will respond to the question "If you had a daughter, how willing would you be to give your daughter an HPV vaccine at 12 years of age?" This will be assessed on a 5-point scale from "not at all willing" (1) to "very willing" (5). The proportion of parents who select "somewhat" (4) or "very willing" (5) will be tallied as the primary outcome measure.

Recruitment status

TERMINATED

Study phase

Target enrollment

1021 participants

Primary outcome timeframe

same day as intervention

Results posted on

2025-01-15

Participant Flow

Recruitment period: summer 2019 Recruitment locations: immunization clinics and schools in 40 townships in Shanghai, China

Participant milestones

Participant milestones
Measure	Cervical Cancer - Sexually Transmitted (STD) - Standard The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Information about STDs: Caregivers learn that HPV is an STD. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - STD - 12 Years Old (y.o.) The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - STD - 18 y.o. The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - Standard The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - 12 y.o. The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - 18 y.o. The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Blank - Standard The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Cervical Cancer - Blank - 12 y.o. The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Cervical Cancer - Blank - 18 y.o. The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - STD - Standard The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations.	Many Cancers - STD - 12 y.o. The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old.	Many Cancers - STD - 18 y.o. The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old.	Many Cancers - Infectious - Standard The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations.	Many Cancers - Infectious - 12 y.o. The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old.	Many Cancers - Infectious - 18 y.o. The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old.	Many Cancers - Blank - Standard The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - Blank - 12 y.o. The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - Blank - 18 y.o. The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Blank information about communicability: Caregivers are not given any information on how HPV is spread.
Overall Study STARTED	85	49	58	55	52	51	53	55	58	60	62	55	58	55	58	56	51	50
Overall Study COMPLETED	79	45	52	51	48	49	49	52	53	58	57	51	55	52	56	50	48	48
Overall Study NOT COMPLETED	6	4	6	4	4	2	4	3	5	2	5	4	3	3	2	6	3	2

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Many Cancers - STD - 12 y.o. n=57 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old.	Many Cancers - STD - 18 y.o. n=51 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old.	Many Cancers - Infectious - Standard n=55 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations.	Many Cancers - Infectious - 12 y.o. n=52 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old.	Many Cancers - Infectious - 18 y.o. n=56 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old.	Cervical Cancer - Sexually Transmitted (STD) - Standard n=79 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Information about STDs: Caregivers learn that HPV is an STD. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - STD - 12 Years Old (y.o.) n=45 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - STD - 18 y.o. n=52 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - Standard n=51 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - 12 y.o. n=48 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - 18 y.o. n=49 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Blank - Standard n=49 Participants The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Cervical Cancer - Blank - 12 y.o. n=52 Participants The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Cervical Cancer - Blank - 18 y.o. n=53 Participants The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - STD - Standard n=58 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations.	Many Cancers - Blank - Standard n=50 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - Blank - 12 y.o. n=48 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - Blank - 18 y.o. n=48 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Total n=953 Participants Total of all reporting groups
Age, Continuous	37 years n=57 Participants	37 years n=51 Participants	37 years n=55 Participants	37 years n=52 Participants	37 years n=56 Participants	39 years n=79 Participants	38 years n=45 Participants	39 years n=52 Participants	38 years n=51 Participants	35 years n=48 Participants	37.5 years n=49 Participants	39 years n=49 Participants	36 years n=52 Participants	37 years n=53 Participants	36 years n=58 Participants	37 years n=50 Participants	38 years n=48 Participants	38 years n=48 Participants	37 years n=953 Participants
Sex: Female, Male Female	44 Participants n=57 Participants	41 Participants n=51 Participants	43 Participants n=55 Participants	39 Participants n=52 Participants	52 Participants n=56 Participants	61 Participants n=79 Participants	34 Participants n=45 Participants	38 Participants n=52 Participants	40 Participants n=51 Participants	37 Participants n=48 Participants	37 Participants n=49 Participants	40 Participants n=49 Participants	45 Participants n=52 Participants	46 Participants n=53 Participants	47 Participants n=58 Participants	34 Participants n=50 Participants	40 Participants n=48 Participants	40 Participants n=48 Participants	758 Participants n=953 Participants
Sex: Female, Male Male	13 Participants n=57 Participants	10 Participants n=51 Participants	12 Participants n=55 Participants	13 Participants n=52 Participants	4 Participants n=56 Participants	18 Participants n=79 Participants	11 Participants n=45 Participants	14 Participants n=52 Participants	11 Participants n=51 Participants	11 Participants n=48 Participants	12 Participants n=49 Participants	9 Participants n=49 Participants	7 Participants n=52 Participants	7 Participants n=53 Participants	11 Participants n=58 Participants	16 Participants n=50 Participants	8 Participants n=48 Participants	8 Participants n=48 Participants	195 Participants n=953 Participants
Race and Ethnicity Not Collected	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	0 Participants Race and Ethnicity were not collected from any participant.
Region of Enrollment China	57 participants n=57 Participants	51 participants n=51 Participants	55 participants n=55 Participants	52 participants n=52 Participants	56 participants n=56 Participants	79 participants n=79 Participants	45 participants n=45 Participants	52 participants n=52 Participants	51 participants n=51 Participants	48 participants n=48 Participants	49 participants n=49 Participants	49 participants n=49 Participants	52 participants n=52 Participants	53 participants n=53 Participants	58 participants n=58 Participants	50 participants n=50 Participants	48 participants n=48 Participants	48 participants n=48 Participants	953 participants n=953 Participants
Vaccinated at baseline	4 Participants n=57 Participants	2 Participants n=51 Participants	3 Participants n=55 Participants	3 Participants n=52 Participants	3 Participants n=56 Participants	4 Participants n=79 Participants	4 Participants n=45 Participants	2 Participants n=52 Participants	1 Participants n=51 Participants	4 Participants n=48 Participants	6 Participants n=49 Participants	2 Participants n=49 Participants	3 Participants n=52 Participants	2 Participants n=53 Participants	3 Participants n=58 Participants	2 Participants n=50 Participants	2 Participants n=48 Participants	3 Participants n=48 Participants	53 Participants n=953 Participants

PRIMARY outcome

Timeframe: same day as intervention

Outcome measures

Outcome measures
Measure	Cervical Cancer - Sexually Transmitted (STD) - Standard n=79 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Information about STDs: Caregivers learn that HPV is an STD. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - STD - 12 Years Old (y.o.) n=45 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - STD - 18 y.o. n=52 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - Standard n=51 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - 12 y.o. n=48 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Infectious - 18 y.o. n=49 Participants The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer.	Cervical Cancer - Blank - Standard n=49 Participants The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Cervical Cancer - Blank - 12 y.o. n=52 Participants The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Cervical Cancer - Blank - 18 y.o. n=53 Participants The Human Papilloma Virus (HPV) causes cervical cancer. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Cervical cancer: Caregivers are told that HPV causes cervical cancer. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - STD - Standard n=58 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations.	Many Cancers - STD - 12 y.o. n=57 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old.	Many Cancers - STD - 18 y.o. n=51 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is a sexually transmitted disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about STDs: Caregivers learn that HPV is an STD. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old.	Many Cancers - Infectious - Standard n=55 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations.	Many Cancers - Infectious - 12 y.o. n=52 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old.	Many Cancers - Infectious - 18 y.o. n=56 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Information about infectious disease: Caregivers learn that HPV is infectious (but information that it is an STD is omitted). Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old.	Many Cancers - Blank - Standard n=50 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Standard age information: Caregivers are given information about when the HPV vaccination can be given in China, but no additional recommendations. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - Blank - 12 y.o. n=48 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Recommendation for children 12 years old: Caregivers are prompted to get their child vaccinated when the child is 12 years old. Blank information about communicability: Caregivers are not given any information on how HPV is spread.	Many Cancers - Blank - 18 y.o. n=48 Participants The Human Papilloma Virus (HPV) causes cancers all over the body, from the head to the reproductive system. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between high school and college or work is a particularly good time to think about the HPV vaccine. Broadened information about cancers: Caregivers receive information that HPV causes more than just cervical cancer. Recommendation for children 18 years old: Caregivers are prompted to get their child vaccinated when the child is 18 years old. Blank information about communicability: Caregivers are not given any information on how HPV is spread.
To Determine How the Framing of the HPV Vaccination Across Several Dimensions Affects Short-term Willingness to Receive it	46 Participants	31 Participants	29 Participants	21 Participants	28 Participants	26 Participants	28 Participants	23 Participants	31 Participants	35 Participants	33 Participants	27 Participants	33 Participants	31 Participants	29 Participants	22 Participants	28 Participants	25 Participants

SECONDARY outcome

Timeframe: 3 years

Population: This study was terminated early because of COVID-19, and data on the secondary outcome were not collected.

Three years after the experimental component, parents will respond to the question "If you had a daughter, how willing would you be to give your daughter an HPV vaccine at 12 years of age?" This will be assessed on a 5-point scale from "not at all willing" (1) to "very willing" (5). The proportion of parents who select "somewhat" (4) or "very willing" (5) will be tallied as the primary outcome measure.