Heart Rate Variability Biofeedback for Smoking Cessation

NCT ID: NCT03972137

Last Updated: 2020-08-25

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-24

Study Completion Date

2020-02-20

Brief Summary

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Open trial of heart rate variability biofeedback as an adjunct to individualized smoking cessation counseling (SCT) plus transdermal nicotine replacement patch (NRT) in smokers with elevated emotional distress.

Detailed Description

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The investigators propose to develop and pilot test heart rate variability biofeedback (HRVB) for smokers with elevated emotional distress as an adjunct to individual smoking cessation counseling (SCT) and transdermal nicotine patch (NRT). In this open trial, all participants received the active intervention. Findings will be used to refine the protocol in advance of a subsequent Phase III randomized clinical trial.

Conditions

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Tobacco Smoking

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

All participants received individualized smoking cessation therapy (SCT), nicotine replacement therapy patch (NRT) and heart rate variability biofeedback (HRVB).
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

This is an open trial with all participants receiving what will become the 'active intervention' in a subsequent randomized clinical trial.

Study Groups

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Heart Rate Variability Biofeedback-Smoking Cessation Therapy

All participants in this open trial received individualized cognitive-behavioral smoking cessation treatment (SCT), up to 8 weeks of the transdermal nicotine patch (NRT) and individualized heart rate variability biofeedback (HRVB).

Group Type EXPERIMENTAL

Cognitive-Behavioral Smoking Cessation

Intervention Type BEHAVIORAL

Participants were provided with six individualized smoking cessation counseling sessions designed to help them prepare to quit, set a quit date, behaviorally manage early abstinence, and to resume cessation upon lapse.

Heart Rate Variability Biofeedback (HRVB)

Intervention Type BEHAVIORAL

All participants were provided with individualized training in resonance breathing using biofeedback to help improve self-regulation.

Transdermal Nicotine patch

Intervention Type DRUG

All participants were offered up to eight weeks of transdermal nicotine patch, beginning on their quit date.

Interventions

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Cognitive-Behavioral Smoking Cessation

Participants were provided with six individualized smoking cessation counseling sessions designed to help them prepare to quit, set a quit date, behaviorally manage early abstinence, and to resume cessation upon lapse.

Intervention Type BEHAVIORAL

Heart Rate Variability Biofeedback (HRVB)

All participants were provided with individualized training in resonance breathing using biofeedback to help improve self-regulation.

Intervention Type BEHAVIORAL

Transdermal Nicotine patch

All participants were offered up to eight weeks of transdermal nicotine patch, beginning on their quit date.

Intervention Type DRUG

Other Intervention Names

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Cognitive-behavioral therapy Smoking cessation counseling (SCT) Biofeedback Respiratory biofeedback Nicotine patch Nicotine replacement therapy (NRT)

Eligibility Criteria

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Inclusion Criteria

* Smoking ≥5 cigarettes, daily, for at least two years
* expired carbon monoxide analysis of breath sample ≥8 ppm
* elevated affective distress
* motivation to quit
* computer proficient

Exclusion Criteria

* current use of other tobacco or nicotine products for recreation or to aid in cessation, use of pharmacological intervention for cessation, or current enrollment in a psychosocial intervention for smoking cessation
* endorsement of current or past psychotic or manic symptoms indicative of bipolar spectrum or schizophrenia spectrum disorders and/or current suicidal or homicidal ideation
* inability to provide written informed consent
* current evidence of another substance use disorder
* severe visual or hearing impairments
* self-reported medical condition or medication use that may be contraindicated for participation in a HRVB or confound autonomic parameters:
* self-reported medical issues of potential concern to nicotine patch users
Minimum Eligible Age

21 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

Rutgers, The State University of New Jersey

OTHER

Sponsor Role lead

Responsible Party

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Teresa M. Leyro, Ph.D.

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Teresa Leyro, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Rutgers, The State University of New Jersey

Locations

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Rutgers, School of Arts and Sciences, One Spring Street

New Brunswick, New Jersey, United States

Site Status

Countries

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United States

References

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Leyro TM, Buckman JF, Bates ME. Theoretical implications and clinical support for heart rate variability biofeedback for substance use disorders. Curr Opin Psychol. 2019 Dec;30:92-97. doi: 10.1016/j.copsyc.2019.03.008. Epub 2019 Apr 2.

Reference Type BACKGROUND
PMID: 31055246 (View on PubMed)

Provided Documents

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Document Type: Informed Consent Form

View Document

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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R34DA043751

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2018001848

Identifier Type: -

Identifier Source: org_study_id

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