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Neural Activations During Imaginal Exposure in Individuals Fearful of Spiders

NCT ID: NCT03969160

Last Updated: 2019-05-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-11

Study Completion Date

2018-02-22

Brief Summary

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This study explores the brain basis of imaginal exposure, a widely used psychological treatment technique. Specifically, this study uses functional magnetic resonance imaging to examine brain areas activated during imaginal exposure, in individuals fearful of spiders. Physiological responses and subjective fear experienced during imaginal exposure are also assessed.

The primary aim of this study is to explore differences in neural activity during exposure to phobic, compared to neutral, mental imagery. The study will focus primarily on exploratory whole brain analyses, but will also include regions of interest analyses on brain areas previously associated with imaginal exposure. The experimental procedure consists of repeated exposure to mental imagery, i.e. imagery of short durations, including either highly emotion-provoking or neutral content, prompted by verbal instructions. A secondary aim is to explore the effects of repeated exposure to mental imagery, used during the experimental procedure, on subjective fear and physiological responses.

Detailed Description

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Results will elucidate if neural activity to phobic imagery differs from activity associated with the production of mental imagery per se. Findings will also increase our general understanding of the neural basis of imaginal exposure treatments.

Conditions

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Individuals With Fear of Spiders

Keywords

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Imaginal exposure brain imaging mental imagery

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Imaginal exposure

The experimental procedure consists of imaginal exposure to mental imagery of phobic and neutral stimuli, prompted through recorded verbal instructions. Participants' repeat the experimental procedure one week later in a follow-up session. Brain imaging data is only collected during day 1

Group Type EXPERIMENTAL

Imaginal exposure

Intervention Type BEHAVIORAL

Imaginal exposure to mental imagery of phobic and neutral stimuli

Interventions

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Imaginal exposure

Imaginal exposure to mental imagery of phobic and neutral stimuli

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Significant fear of spiders

Exclusion Criteria

* Current psychiatric disorder other than spider phobia
* Substance abuse
* Neurological disease
* Psychological treatment or psychotropic medication within six months
* Magnetic resonance imaging contradiction
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Uppsala University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Uppsala University Hospital - Akademiska sjukhuset

Uppsala, , Sweden

Site Status

Uppsala University, Departement of Psychology

Uppsala, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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2017/419

Identifier Type: -

Identifier Source: org_study_id