Real World Study of Four PD-1 Agents in China

NCT ID: NCT03966456

Last Updated: 2019-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-01

Study Completion Date

2023-06-01

Brief Summary

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Consecutive patients treated with PD-1 therapy in Qingdao City were included in our study. The effecy and safety of the four PD-1 agents according to clinical outcomes in real world will be studied.

Detailed Description

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Consecutive patients treated with PD-1 therapy in Qingdao City were included in our study. The effecy and safety of the four PD-1 agents according to clinical outcomes in real world will be studied. ORR will be studied of the four PD-1 agents(nivolumab, pembrolizumab, toripalimab, sintilimab)

Conditions

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Thoracic Cancer Gynecologic Cancer Abdomen Tumors Malignant Melanoma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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nivolumab

Consecutive patients treated with nivolumab single or combined chemotherapy/targeting therapy.

Chemotherapy

Intervention Type DRUG

compare the effecy and safety of 4 PD-1 agents single and combined with chemotherapy in chinese people.

pembrolizumab

Consecutive patients treated with pembrolizumab single or combined chemotherapy/targeting therapy.

Chemotherapy

Intervention Type DRUG

compare the effecy and safety of 4 PD-1 agents single and combined with chemotherapy in chinese people.

toripalimab

Consecutive patients treated with toripalimab single or combined chemotherapy/targeting therapy.

Chemotherapy

Intervention Type DRUG

compare the effecy and safety of 4 PD-1 agents single and combined with chemotherapy in chinese people.

sintilimab

Consecutive patients treated with sintilimab single or combined chemotherapy/targeting therapy.

Chemotherapy

Intervention Type DRUG

compare the effecy and safety of 4 PD-1 agents single and combined with chemotherapy in chinese people.

Interventions

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Chemotherapy

compare the effecy and safety of 4 PD-1 agents single and combined with chemotherapy in chinese people.

Intervention Type DRUG

Other Intervention Names

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targeting therapy

Eligibility Criteria

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Inclusion Criteria

* Patients with lung cancer, liver cancer and other solid cancers
* Histologically or cytologically confirmed diagnosis cancer treated with PD-1 agents
* At least one measurable lesion
* Eastern Cooperative Oncology Group (ECOG) Performance Scale 0 or 1 Adequate organ function

Exclusion Criteria

* patients treated with PD-1 agents less than 2 terms
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Affiliated Hospital of Qingdao University

OTHER

Sponsor Role lead

Responsible Party

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zhangxiaochun

Director of Cancer Precision Medical Center

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xiaochun Zhang, Dr

Role: PRINCIPAL_INVESTIGATOR

The Affiliated Hospital of Qingdao University

Locations

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The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiaochun Zhang, Dr

Role: CONTACT

+86-532-82915333

Man Jiang, Dr

Role: CONTACT

+86-532-82915333

Facility Contacts

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Xiaochun Zhang, Dr

Role: primary

+86-532-82915333

Other Identifiers

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Ic-01

Identifier Type: -

Identifier Source: org_study_id

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