The PRECIOUS Study: Predicting Crohn's & ColitIs Outcomes in the United States

NCT ID: NCT03952364

Last Updated: 2021-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-10

Study Completion Date

2022-06-30

Brief Summary

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A multi-center observational study based at referral centers and community hospitals within the US. Patients' blood will be collected at enrollment for testing with PredictSURE IBD™, which will occur at a later date. Patients will be prospectively followed up for 12 months with clinicians treating according to local standard of care, with a step-up or accelerated step-up regimen. Clinicians and patients will be blinded to the biomarker results.

Detailed Description

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This is a multi-center, observational study of newly diagnosed IBD (CD or UC) patients. The Study aims to assess whether a prognostic biomarker can stratify IBD patients in the US.

Conditions

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Crohn Disease Ulcerative Colitis IBD Inflammatory Bowel Diseases

Study Design

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Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Interventions

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PredictSURE IBD™

To evaluate a test called PredictSURE IBD™ in the US population

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Active UC or CD with typical symptoms in conjunction with at least one objective measure of disease activity: elevated CRP, calprotectin, endoscopic evidence.
* Not currently receiving systemic therapy\* with steroids, immunomodulators or biologics, and at least 7 days since the last steroid dose.
* Due to be managed using a "step-up" or "accelerated step-up" approach (so will not receive biologics as first line therapy).
* Aged 16-80 years old.

Note, the ideal patients for this study are newly diagnosed patients who are treatment-naïve.

Exclusion Criteria

* The presence of any of the following will preclude patient inclusion:
* Patients with fistulating peri-anal Crohn's disease or active perianal sepsis.
* Obstructive symptoms and evidence of a fixed stricture on radiology or colonoscopy.
* Patients who are scheduled to start on "top-down" therapy or receive biologics as a first line therapy
Minimum Eligible Age

16 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Crohn's and Colitis Foundation

OTHER

Sponsor Role collaborator

PredictImmune Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James Lee, MD

Role: PRINCIPAL_INVESTIGATOR

PredictImmune Ltd

Locations

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University of Miami Crohn's and Colitis Center

Miami, Florida, United States

Site Status RECRUITING

Washington University in St. Louis

St Louis, Missouri, United States

Site Status RECRUITING

Rutgers Robert Wood Johnson Medical School (Adult)

New Brunswick, New Jersey, United States

Site Status RECRUITING

Rutgers Robert Wood Johnson Medical School (Prediatric)

New Brunswick, New Jersey, United States

Site Status RECRUITING

Manhattan Clinical Research, LLC.

New York, New York, United States

Site Status RECRUITING

NYU Langone Health

New York, New York, United States

Site Status RECRUITING

Weill Cornell Medical Center

New York, New York, United States

Site Status RECRUITING

ClinSearch

Chattanooga, Tennessee, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Karen Hills, PhD

Role: CONTACT

+44 (0) 1223 804195

Facility Contacts

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Mills Grechen

Role: primary

305-243-6405

Baylee Kinnett

Role: primary

Roohi Patel, MD

Role: primary

Lisa Cerracchio

Role: primary

732-235-5976

Resmi Varughese

Role: primary

212-889-5544 ext. 9472

Ghoncheh Ghiasian

Role: primary

646-501-7822

Laura Cvetkovski

Role: primary

646-697-0985 ext. 2220988

Misti Earwood

Role: primary

423-698-4584

Other Identifiers

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The Precious Study

Identifier Type: -

Identifier Source: org_study_id