A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma

NCT ID: NCT03941379

Last Updated: 2023-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-27

Study Completion Date

2029-12-31

Brief Summary

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The purpose of this observational research study is to follow participants who have been treated with either bel-sar or received alternate treatment (sham, standard of care therapy, etc.) while participating in a previous Aura Biosciences clinical research study to assess the long-term safety and effectiveness in these subjects. This study will collect information from procedures conducted as part of routine follow-up eye care and cancer care. Additionally, the registry will collect all adverse events, information about pregnancy and symptomatic overdose.

Detailed Description

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This is a multi-center long-term observational Registry of subjects with Primary Indeterminate Lesions or Choroidal Melanoma.

The Registry will initially be open to subjects who have previously participated in an Aura Biosciences bel-sar sponsored clinical trial for their primary Choroidal Melanoma or Indeterminate Lesions.

All subjects will be followed for a minimum of 5 years (including time enrolled in an Aura sponsored clinical trial), until withdrawal of consent, or until death whichever comes first.

No interventions will be required as part of the Registry. Data collection will be based on IL or CM information anticipated to be available based on the standard of care for subjects with CM or IL.

Conditions

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Choroidal Melanoma Indeterminate Lesions of Eye

Keywords

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Choroidal Melanoma Indeterminate Lesions of Eye

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Subjects previously participated in an Aura Biosciences bel-sar study

Subjects with Choroidal Melanoma or Indeterminate Lesions.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Have been clinically diagnosed with primary IL or CM at the time of entry to a previous Aura Biosciences sponsored clinical trial.
* Have received AU-011 bel-sar or assigned to a different cohort or treatment arm (sham, SoC, etc.) an observation cohort in a previous Aura sponsored clinical trial.

Exclusion Criteria

\- None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aura Biosciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Aura Biosciences Inc.

Locations

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Retina Associates SW, P.C.

Tucson, Arizona, United States

Site Status RECRUITING

UCLA Jules Stein Eye Institute

Los Angeles, California, United States

Site Status RECRUITING

Byers Eye Institute at Stanford University

Palo Alto, California, United States

Site Status RECRUITING

Retina Consultants of Sacramento

Sacramento, California, United States

Site Status ACTIVE_NOT_RECRUITING

Massachusetts Eye and Ear Infirmary

Boston, Massachusetts, United States

Site Status RECRUITING

W. K. Kellogg Eye Center, University of Michigan

Ann Arbor, Michigan, United States

Site Status RECRUITING

Associated Retinal Consultants, PC

Royal Oak, Michigan, United States

Site Status RECRUITING

Retina Center

Minneapolis, Minnesota, United States

Site Status RECRUITING

Columbia University Medical Center

New York, New York, United States

Site Status RECRUITING

Oregon Health & Science University Casey Eye Institute

Portland, Oregon, United States

Site Status RECRUITING

Wills Eye Hospital

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Retina Consultants of Carolina, PA

Greenville, South Carolina, United States

Site Status RECRUITING

St. Thomas Health / Tennessee Retina, PC

Nashville, Tennessee, United States

Site Status RECRUITING

Texas Retina Associates

Dallas, Texas, United States

Site Status RECRUITING

Retina Consultants of Houston

Houston, Texas, United States

Site Status RECRUITING

University of Wisconsin

Madison, Wisconsin, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Medical Monitor

Role: CONTACT

Phone: 617-500-8864

Email: [email protected]

Medical Monitor

Role: CONTACT

Facility Contacts

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Amy Merz

Role: primary

Rosaleen Ostrick

Role: primary

Mariana Nunez

Role: primary

Grayson Hanlon

Role: primary

Pamela Campbell

Role: primary

Kendra Mellert

Role: primary

Andi Gilchrist, BS CMSS

Role: primary

Ellen Alt

Role: primary

Ann Lundquist

Role: primary

Lisa Flynn

Role: primary

Lauren Frazier

Role: primary

Lisa Walden

Role: primary

Sally Arceneaux

Role: primary

Allison Stroh

Role: primary

Bonnie Verges

Role: primary

Related Links

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Other Identifiers

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Registry AU-011-401

Identifier Type: -

Identifier Source: org_study_id