Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane

NCT ID: NCT03930680

Last Updated: 2025-07-08

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-14

Study Completion Date

2025-06-11

Brief Summary

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The purpose of this research study is to determine whether early administration of Dexrazoxane prevents Doxorubicin induced cardiotoxicity.

Detailed Description

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This is a study on volunteers to determine effective dose of dexrazoxane in degrading Topoisomerase 2 b in human blood samples. Each participant will receive one dose of dexrazoxane. Blood samples will be collected to determine the time course and degradation of Topoisomerase 2b and Topoisomerase 2a

Conditions

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Degradation of Top2b and Top2a in Human by Dexrazoxane Time Course and Degradation of Top2b in Human by Dexrazoxane Effects of Dexrazoxane on Healthy Human

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Each subject will receive one dose of dexrazoxane.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Dexrazoxane 100mg/m2

one dose of 100mg/m2 dexrazoxane

Group Type EXPERIMENTAL

Dexrazoxane

Intervention Type DRUG

One dose of dexrazoxane

Dexrazoxane 200mg/m2

one dose of 200mg/m2 dexrazoxane

Group Type EXPERIMENTAL

Dexrazoxane

Intervention Type DRUG

One dose of dexrazoxane

Dexrazoxane 300mg/m2

one dose of 300mg/m2 dexrazoxane

Group Type EXPERIMENTAL

Dexrazoxane

Intervention Type DRUG

One dose of dexrazoxane

Dexrazoxane 400mg/m2

one dose of 400mg/m2 dexrazoxane

Group Type EXPERIMENTAL

Dexrazoxane

Intervention Type DRUG

One dose of dexrazoxane

Dexrazoxane 500mg/m2

one dose of 500 mg/m2

Group Type EXPERIMENTAL

Dexrazoxane

Intervention Type DRUG

One dose of dexrazoxane

Interventions

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Dexrazoxane

One dose of dexrazoxane

Intervention Type DRUG

Other Intervention Names

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Zinecard

Eligibility Criteria

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Inclusion Criteria

* Women,
* Age 18-65,
* Not pregnant, Not currently breast feeding
* No current illness,

Exclusion Criteria

* Pregnancy, currently breast feeding
* Current illness,
* History of cardiac, or renal disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

University of Arkansas

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hui-Ming Chang, MD,MPH

Role: PRINCIPAL_INVESTIGATOR

University of Arkansas

Locations

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University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Site Status

Countries

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United States

References

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Chang HM, Hsu JY, Ahn C, Yeh ETH. Prevention of Heart Failure Induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX Study): dose response and time course of dexrazoxane-induced degradation of topoisomerase 2b. Cardiooncology. 2025 May 2;11(1):42. doi: 10.1186/s40959-025-00339-0.

Reference Type RESULT
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Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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R01HL151993

Identifier Type: NIH

Identifier Source: secondary_id

View Link

262180

Identifier Type: -

Identifier Source: org_study_id

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