Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
5000 participants
OBSERVATIONAL
2011-01-01
2032-01-01
Brief Summary
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The Homburg Keratoconus Center (HKC) was founded in 2010 and, up to now, comprises more than 3,000 Keratoconus patients. Topographic, tomographic and biomechanic characteristics of the disease are being analyzed with the intention to elucidate how the disease begins and develops during lifetime.
Detailed Description
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Conditions
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Study Design
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COHORT
OTHER
Study Groups
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Patients with Keratoconus
Aim is to include as many Keratoconus patients as possible with the intention to elucidate how the disease begins and develops during lifetime.
Topographic, tomographic and biomechanical analysis.
The study is based upon data obtained during routine medical follow-ups using
1. the Pentacam high resolution (Oculus, Wetzlar, Germany)
2. the Corvis ST (Oculus, Wetzlar, Germany)
3. the Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2 (Tomey, Nagoya, Japan)
4. the Ocular Response Analyzer (Reichert Technologies, New York, USA).
Interventions
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Topographic, tomographic and biomechanical analysis.
The study is based upon data obtained during routine medical follow-ups using
1. the Pentacam high resolution (Oculus, Wetzlar, Germany)
2. the Corvis ST (Oculus, Wetzlar, Germany)
3. the Anterior-Segment Optical Coherence Tomograph (AS-OCT) Casia 2 (Tomey, Nagoya, Japan)
4. the Ocular Response Analyzer (Reichert Technologies, New York, USA).
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Universität des Saarlandes
OTHER
Responsible Party
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Elias Flockerzi
Principal Investigator, Resident of Ophthalmology
Locations
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Department of Ophthalmology
Homburg, Saarland, Germany
Countries
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Facility Contacts
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References
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Flockerzi E, Seitz B. Keratectasia severity staging and progression assessment based on the biomechanical E-staging. Eye Vis (Lond). 2024 Jul 1;11(1):24. doi: 10.1186/s40662-024-00392-3.
Sideroudi H, Flockerzi E, Daas L, Jullien T, Xanthopoulou K, Hamon L, Seitz B. Baseline Characteristics of 1976 Patients With Ectatic Corneal Disorders at a Single Center From 2010 to 2021: A Cross-Sectional Study of the Homburg Keratoconus Center. Eye Contact Lens. 2023 Sep 1;49(9):392-398. doi: 10.1097/ICL.0000000000001014. Epub 2023 Jul 14.
Flockerzi E, Vinciguerra R, Belin MW, Vinciguerra P, Ambrosio R Jr, Seitz B. Combined biomechanical and tomographic keratoconus staging: Adding a biomechanical parameter to the ABCD keratoconus staging system. Acta Ophthalmol. 2022 Aug;100(5):e1135-e1142. doi: 10.1111/aos.15044. Epub 2021 Oct 16.
Flockerzi E, Elzer B, Daas L, Xanthopoulou K, Eppig T, Langenbucher A, Seitz B. The Reliability of Successive Scheimpflug Imaging and Anterior Segment Optical Coherence Tomography Measurements Decreases With Increasing Keratoconus Severity. Cornea. 2021 Nov 1;40(11):1433-1439. doi: 10.1097/ICO.0000000000002657.
Flockerzi E, Vinciguerra R, Belin MW, Vinciguerra P, Ambrosio R Jr, Seitz B. Correlation of the Corvis Biomechanical Factor with tomographic parameters in keratoconus. J Cataract Refract Surg. 2022 Feb 1;48(2):215-221. doi: 10.1097/j.jcrs.0000000000000740.
Flockerzi E, Hafner L, Xanthopoulou K, Daas L, Munteanu C, Langenbucher A, Seitz B. Reliability analysis of successive Corneal Visualization Scheimpflug Technology measurements in different keratoconus stages. Acta Ophthalmol. 2022 Feb;100(1):e83-e90. doi: 10.1111/aos.14857. Epub 2021 Mar 22.
Flockerzi E, Xanthopoulou K, Goebels SC, Zemova E, Razafimino S, Hamon L, Jullien T, Kluhspies U, Eppig T, Langenbucher A, Seitz B. Keratoconus staging by decades: a baseline ABCD classification of 1000 patients in the Homburg Keratoconus Center. Br J Ophthalmol. 2021 Aug;105(8):1069-1075. doi: 10.1136/bjophthalmol-2020-316789. Epub 2020 Aug 23.
Flockerzi E, Xanthopoulou K, Daas L, Feld S, Langenbucher A, Seitz B. Evaluation of Dynamic Corneal Response Parameters and the Biomechanical E-Staging After Accelerated Corneal Cross-Linking in Keratoconus. Asia Pac J Ophthalmol (Phila). 2022 Nov 1;11(6):514-520. doi: 10.1097/APO.0000000000000580.
Other Identifiers
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HKC
Identifier Type: -
Identifier Source: org_study_id