CT-guided Radioactive I-125 Seeds Implantation for Early Stage Lung Cancer

NCT ID: NCT03916367

Last Updated: 2019-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

39 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-12-15

Study Completion Date

2019-02-15

Brief Summary

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This study observes the efficacy and side effects of CT-guided radioactive iodine-125 seed brachytherapy in inoperable early stage non-small cell lung cancer retrospectively, and analyzes the influence of clinical and dosimetric factors on the outcomes.

Detailed Description

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Radioactive Iodine-125 seed brachytherapy is a conventional treatment in Peking University Third Hospital. Radioactive Iodine-125 seed brachytherapy is the implantation of Iodine-125 seed into tumors.The radioactive Iodine-125 seed can release low dose of irradiation persistently which kills tumors cell and causes less damage to normal tissue at the same time. This study collects the data of patients with early stage (stage I-II, N0) non-small cell lung cancer who underwent CT-guided radioactive Iodine-125 seed implantation from 2010 to 2018. The investigators evaluate the dose that covers 90% target volume(D90) and other parameters after the implantation. The efficacy and adverse effects were observed. Local control(LC) time and overall survival(OS) time are evaluated.

Conditions

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Early Stage Non-small Cell Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Early Stage Lung Cancer

The patients with early stage non-small cell lung cancer who were treated with CT-guided radioactive iodine-125 seeds implantation during December 2010 to December 2018.

CT-guided Radioactive I-125 Seeds Implantation

Intervention Type RADIATION

The radioactive Iodine-125 seed can release low dose of irradiation persistently which kills tumors cell and causes less damage to normal tissue at the same time. The treatment was performed under CT monitoring.

Interventions

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CT-guided Radioactive I-125 Seeds Implantation

The radioactive Iodine-125 seed can release low dose of irradiation persistently which kills tumors cell and causes less damage to normal tissue at the same time. The treatment was performed under CT monitoring.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* histological proven non-small cell lung cancer
* UICC (Union for International Cancer Control) stage was T1-3N0M0 (stage Ia-IIb)
* inoperable and CT-guided radioactive iodine-125 seeds brachytherapy was used as the initial treatment without external beam radiotherapy

Exclusion Criteria

* actual dose of covers 90% target volume (D90) less than 100 Gy in postoperative validation
* case information and/or follow-up information was unavailable
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University Third Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Junjie Wang, M.D. Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Department of Radiation Oncology, Peking University Third Hospital

Other Identifiers

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CNRBG-81532-ESNSCLC-RISI

Identifier Type: -

Identifier Source: org_study_id

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