The Salivary Microbiome in Children With Type 1 Diabetes Mellitus
NCT ID: NCT03908021
Last Updated: 2022-03-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
66 participants
OBSERVATIONAL
2019-08-01
2021-12-30
Brief Summary
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Research: exploring the differences between oral microflora of children with type 1 diabetes mellitus and control healthy children using salivary microbiome. The investigators will furthermore intend to analyze the differences of salivary flow rate, pH, glucose, calcium, inorganic phosphate and urea between the two groups.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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children with type 1 diabetes mellitus
Saliva from 50 children ages 5 to 15 years old who had been diagnosed with type 1 diabetes mellitus and are followed at the Pediatric Endocrinology Clinic, Hadassah University Hospital Mt. Scopus and Ein Kerem, Jerusalem, Isreal,
Microbiome analysis and 16S rRNA gene-based analysis
microbial DNA is extracted from the saliva and 16s library is prepared for sequencing.
Control
50 healthy children, preferably their siblings, matched in age and gender.
Microbiome analysis and 16S rRNA gene-based analysis
microbial DNA is extracted from the saliva and 16s library is prepared for sequencing.
Interventions
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Microbiome analysis and 16S rRNA gene-based analysis
microbial DNA is extracted from the saliva and 16s library is prepared for sequencing.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Children On antibacterial medicaments
5 Years
15 Years
ALL
No
Sponsors
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Hadassah Medical Organization
OTHER
Responsible Party
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Locations
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Hadassah Medical Organization
Jerusalem, , Israel
Countries
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Other Identifiers
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0714-18-HMO
Identifier Type: -
Identifier Source: org_study_id
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