Effect Mode of Delivery and Feeding on Body Composition and Nutritional Status of Children

NCT ID: NCT03900663

Last Updated: 2019-04-03

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-06-30
• Study Completion Date: 2021-10-31

Brief Summary

• Feeding and growth during infancy have been associated with later life body mass index.
• Breastfeeding seems to have a small but consistent protective effect against obesity in children.
• The Cholesterol content of human milk is 6-fold greater than that of the standard infant formulas.
• Infants delivered by caesarean section may be at increased risk of childhood obesity and adulthood obesity.

Detailed Description

• Previous guidelines recommended that infants who are exclusively breast fed for the first 6 months of life, with particular solid foods gradually introduced from 6 months associated with lower childhood fat mass.
• The stated reason for discouraging introduction of solids to infant before 4 months include the risk of excessive weight gain, vulnerability of the gut to infection and increased susceptibility to the development of allergic disease.
• Infants whose dietary pattern was most similar to feeding guidelines, with high frequencies of fresh fruit and vegetables, home prepared foods and breast milk, gained weight and skin fold thickness more rapidly from 6 to12 months than other infants, independent of milk feeding, age of introduction of solids and maternal factors.
• Exclusively breastfed infants had significantly higher Total Cholesterol (TC) level and Low density Lipoprotein level (LDL) and lower High density lipoprotein level (HDL) as compared to mixed-fed infants in the first 6 months of life.
• Exclusive breast feeding seems to have a protective effect against some risk factors for cardiovascular disease in later life, as those who exclusively breastfed had lower level of plasma low density lipoprotein (LDL) cholesterol conc., higher level of high density lipoprotein (HDL) and lower LDL/HDL ratio than those bottle fed.
• Early weaning is related to rapid weight gain in infancy, and this may have implication for childhood obesity.
• Vaginally delivered children are colonised with bacterial strains from the mothers' vagina during delivery in contrast to children delivered by CS, and these differences seem to persist throughout infancy.
• The gut microbiota may have a role in energy harvesting, hence inoculation with maternal microbiota through vaginal delivery may be protective for childhood overweight compared with delivery by CS.

Conditions

Child Obesity

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Breast fed infants

Anthropometric measures

Intervention Type: DEVICE

Measure body weight , height , chest circumference , mid upper arm circumference,skin fold thickness , head circumference

Formula fed infants

Anthropometric measures

Intervention Type: DEVICE

Measure body weight , height , chest circumference , mid upper arm circumference,skin fold thickness , head circumference

vaginally delivered infants

Anthropometric measures

Intervention Type: DEVICE

Measure body weight , height , chest circumference , mid upper arm circumference,skin fold thickness , head circumference

Infants delivered by caesarean section

Anthropometric measures

Intervention Type: DEVICE

Measure body weight , height , chest circumference , mid upper arm circumference,skin fold thickness , head circumference

Interventions

Anthropometric measures

Measure body weight , height , chest circumference , mid upper arm circumference,skin fold thickness , head circumference

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Infants of both sexes
• Infants from 2 to 3 years
• Breast fed or formula fed or mixed fed infants

Exclusion Criteria

• Children less than 2 and more than 3 years ago.
• Children having family history of chronic illness
• Children having family history of metabolic
• Children fed cow milk or buffalo milk.
• Infants delivered preterm.

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 3 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

MR Rassmy

Pediatric Resident

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Maher M. Ahmed, Professor

Role: CONTACT

maher.farghali@med.au.edu.eg

01066006605

Osama M. El Asheer, lecturer

Role: CONTACT

Osama_elasheer@med.au.edu.eg

01001348864

References

Harit D, Faridi MM, Aggarwal A, Sharma SB. Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study. Eur J Clin Nutr. 2008 Feb;62(2):203-9. doi: 10.1038/sj.ejcn.1602692. Epub 2007 Feb 28.

Reference Type: BACKGROUND

PMID: 17327867 (View on PubMed)

Goldani HA, Bettiol H, Barbieri MA, Silva AA, Agranonik M, Morais MB, Goldani MZ. Cesarean delivery is associated with an increased risk of obesity in adulthood in a Brazilian birth cohort study. Am J Clin Nutr. 2011 Jun;93(6):1344-7. doi: 10.3945/ajcn.110.010033. Epub 2011 Apr 20.

Reference Type: BACKGROUND

PMID: 21508088 (View on PubMed)

Ravelli AC, van der Meulen JH, Osmond C, Barker DJ, Bleker OP. Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity. Arch Dis Child. 2000 Mar;82(3):248-52. doi: 10.1136/adc.82.3.248.

Reference Type: BACKGROUND

PMID: 10685933 (View on PubMed)

Other Identifiers

Delivery,feeding,child obesity

Identifier Type: -

Identifier Source: org_study_id