Measurement of Perioperative Glomerular Filtration Rate
NCT ID: NCT03881332
Last Updated: 2021-01-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
4 participants
OBSERVATIONAL
2019-12-26
2021-01-22
Brief Summary
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Detailed Description
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Accurate, direct measurements of glomerular filtration rate (GFR) may provide a tool to monitor perioperative onset of rapidly changing renal function. This may subsequently lead to design of randomized controlled trials examining the effects of earlier intervention with the aim to reduce the incidence of perioperative AKI.
Recently a protocol for continuous infusion of low-dose iohexol (CILDI) as a measure of GFR in stable patients over a range of GFR (28-128 mL/min/1.73 m2) has been developed. Accuracy of this infusion protocol was confirmed with the single bolus injection (SBI) method. Data also showed that the continuous infusion protocol of low-dose iohexol is an accurate and precise method when measuring changing GFR even in critical ill patients with variable AKI risks. Accordingly, SBI and CILDI together now allow us to explore unanswered research questions related to perioperative change in renal function.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
75 Years
ALL
No
Sponsors
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University Hospital of North Norway
OTHER
Responsible Party
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Lars Marius Ytrebo
Professor
Principal Investigators
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Lars Marius Ytrebo, PhD
Role: STUDY_CHAIR
University Hospital of North Norway
Locations
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University Hospital of North Norway
Tromsø, Troms, Norway
Countries
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Other Identifiers
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2018/1934
Identifier Type: -
Identifier Source: org_study_id
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