Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
EARLY_PHASE1
6 participants
INTERVENTIONAL
2018-07-01
2018-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
OTHER
NONE
Study Groups
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A
Oral APAP and IV Fomepizole.
Fomepizole
IV 4-MP.
APAP
Oral APAP
B
Oral APAP.
APAP
Oral APAP
Interventions
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Fomepizole
IV 4-MP.
APAP
Oral APAP
Eligibility Criteria
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Inclusion Criteria
* No APAP use in previous 2 weeks
* No ingestion of alcohol or drugs that affect CYP 2E1 over previous 5 days
* No allergy to APAP or fomepizole
* BMI \< 29
Exclusion Criteria
* History of alcohol abuse
* Allergy to APAP or fomepizole
* Screening LFTs above normal range
18 Years
ALL
Yes
Sponsors
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University of Arizona
OTHER
Responsible Party
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Locations
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BUMCP - Department of Medical Toxicology
Phoenix, Arizona, United States
Countries
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References
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Kang AM, Padilla-Jones A, Fisher ES, Akakpo JY, Jaeschke H, Rumack BH, Gerkin RD, Curry SC. The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers. J Med Toxicol. 2020 Apr;16(2):169-176. doi: 10.1007/s13181-019-00740-z. Epub 2019 Nov 25.
Other Identifiers
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1805526976
Identifier Type: -
Identifier Source: org_study_id
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