Topical Remetinostat Gel as Neoadjuvant Therapy in Patients With Squamous Cell Carcinoma (SCC)

NCT ID: NCT03875859

Last Updated: 2021-05-20

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 4 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-12-12
• Study Completion Date: 2021-01-30

Brief Summary

The primary purpose of this study is to determine if 8 weeks of topical remetinostat applied three times daily will suppress Squamous Cell Carcinoma.

Detailed Description

The primary purpose of this study is:

• to determine if 8 weeks of topical remetinostat gel applied 3 times daily (TID) under occlusion will suppress SCC growth
• to determine the overall response rate (ORR) of SCCs after 8 weeks of treatment with topical remetinostat gel 1%, as measured by at least 30% decrease in greatest area (in mm2).

• Subjects with at least 1 biopsy-proven cutaneous SCC will be recruited for this study.
• Subjects will apply remetinostat gel 1% to at least 1 SCC.
• Non-invasive cutaneous SCC lesions, including Bowen's disease, are also eligible for this study
• There is 1 treatment option: Topical remetinostat gel 1% applied 3 times daily.
• The study is a single arm, open label design
• For purposes of ClinicalTrials.gov, there is no secondary outcome.

Conditions

Squamous Cell Carcinoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Remetinostat

Subjects will apply remetinostat gel 1% to at least 1 SCC: Topical remetinostat gel 1% applied 3 times daily.

Group Type: EXPERIMENTAL

Remetinostat

Intervention Type: DRUG

Topical 1% remetinostat gel

Interventions

Remetinostat

Topical 1% remetinostat gel

Intervention Type: DRUG

Other Intervention Names

suberohydroxamic acid phenyl ester (SHAPE); SHAPE Gel; SHP-141; and 4-[[8-(hydroxyamino)-1,8-dioxooctyl]oxy]-benzoic acid methyl ester

Eligibility Criteria

Inclusion Criteria

1. Must have at least one biopsy-proven cutaneous SCC or SCC in situ (SCC-IS) lesion greater than or equal to 5 mm. Non-invasive SCC lesion(s), including Bowen's disease (SCC-IS), are eligible, but must be amenable to surgical resection.

2. 18 years of age or older.

3. Must be willing to apply the topical remetinostat 3 times daily for 8 weeks and cover with an occlusive bandage.

4. Negative serum pregnancy test within 14 days prior to the first dose of study therapy for women of child-bearing potential, defined as a sexually mature woman who has not undergone a hysterectomy or who has not been naturally postmenopausal for at least 24 consecutive months (i.e., who has had menses any time in the preceding 24 consecutive months)

5. Sexually active women of child bearing potential (WCBP) and male patients with a female partner of child-bearing potential must agree to use acceptable methods of contraception to avoid pregnancy (for example, oral, injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive with spermicide; or vasectomized partner) before the first dose of study therapy and for 3 months after the last dose of study therapy

6. Has signed and dated the current, approved informed consent document.

Exclusion Criteria

1. Any large (> 20 mm) SCC lesion. Patients with large SCC lesion(s) will be referred for evaluation for surgical resection.

2. Inoperable locally-advanced and/or non-cutaneous metastatic SCC.

3. SCC lesion(s) in cosmetically-sensitive areas (e.g. tip of nose, eyelid) are not eligible for enrollment. (If a patient has SCC lesion(s) in other areas, those tumor(s) may be considered for enrollment.)

4. Taking any medication known to affect SCC growth

5. Within the past 6 months, has used topical or systemic therapies that might interfere with the evaluation of the study medication during the study. Specifically, these include the topical use at the site of the study tumors:

• Glucocorticoids
• Retinoids either systemically or topically at the tumor site (e.g., etretinate, isotretinoin, tazarotene, tretinoin, adapalene)
• Alpha-hydroxy acids (e.g., glycolic acid, lactic acid) to the tumor site
• 5-fluorouracil or imiquimod

6. Has received treatment with systemic chemotherapy within 60 days prior to starting study medication.

7. Currently receiving systemic medications that could affect SCC tumors (e.g., oral retinoids) or might interact with remetinostat

8. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, recurrent seizure history or psychiatric illness/social situations that would limit compliance with study requirements.

9. Moderate to significant immunosuppression (e.g., active cancer, significant autoimmune disease) and/or receiving immunosuppressive drugs that result in moderate to significant immunosuppression (e.g. low dose oral glucocorticoids do not necessarily exclude a patient)

10. Known or previous hypersensitivity to HDACi

11. History of congestive heart failure, cardiac arrhythmias, or other findings of ventricular dysfunction.

12. Pregnancy or breast-feeding.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Medivir

INDUSTRY

Sponsor Role: collaborator

Kavita Sarin

OTHER

Sponsor Role: lead

Responsible Party

Kavita Sarin

Assistant Professor of Dermatology.

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Kavita Y Sarin, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

Stanford Medical Center

Stanford, California, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

SKIN0050

Identifier Type: OTHER

Identifier Source: secondary_id

IRB-49542

Identifier Type: -

Identifier Source: org_study_id