Monitoring Of Scratch Via Accelerometry In Children

NCT ID: NCT03873220

Last Updated: 2020-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-14

Study Completion Date

2020-06-09

Brief Summary

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Sleep sensors, wrist worn accelerometers, polysomnography (PSG), and associated data analysis platforms would provide quantitative and qualitative knowledge regarding the action of scratching and sleep quantity in a symptomatic atopic dermatitis (AD) population. The overall aim of this research is to validate the use of sensor technology and digital measures to quantitatively and qualitatively evaluate scratch and sleep in AD patients, and specifically in this study in children ages 2 to 11 years. To evaluate this experimental paradigm, the investigators propose using wearable accelerometers, a sleep sensor, PSG, videography and associated traditional patient-reported outcome measures/clinical outcome assessments (PRO/COA) in patients/caregivers with AD in a well-controlled in-laboratory and at-home study.

Detailed Description

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To assess the feasibility of quantifying scratch and sleep in children with Atopic Dermatitis (AD), children, age 2 to 11 years, with AD will be recruited. The subjects will complete specific questionnaires related to itch, sleeping habits and AD and continuously wear two wrist worn accelerometry devices. The EarlySense Sleep Monitor will also be placed underneath the mattress to measure additional sleep related activities.

The study will be comprised of two overnight sleep laboratory site visits. The clinic visits will be followed by a continuous \~48 hour in-home environment assessment period (defined as the subject's daily routine environment). During the sleep lab site visit, the subject and accompanying parent(s)/guardian(s) will sleep overnight at the facility. The subject will be video-recorded during the in-sleep lab visit, wear the wrist accelerometry devices, use the sleep sensor and complete assessments (Depending on age, parent/guardian may complete some assessments). Upon the completion of sleep lab activities the subjects will then continue to wear the wrist accelerometry devices, utilize the sleep sensor and complete Patient Reported Outcome/Clinical Outcome Assessments (PRO/COA) assessments during the 48 hour in-home assessment. At the conclusion of the in-home portion of the assessment, the subject will return the device/s and assessments to the facility and undergo brief assessments/interview.

Conditions

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Atopic Dermatitis

Keywords

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Wearable devices Scratch Sleep

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Monitoring scratch in children

Sensor technology and digital measures will be used to evaluate scratch and sleep in children with atopic dermatitis who will wear watch-like wrist actigraphy devices, sleep monitor, polysomnography, and videography.

Wrist Actigraphy Devices

Intervention Type DEVICE

A watch-like wearable sensor

Sleep Monitor

Intervention Type DEVICE

Remote Sensor

Polysomnography

Intervention Type DEVICE

Sleep Monitor

Videography

Intervention Type DEVICE

Thermal Camera

Interventions

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Wrist Actigraphy Devices

A watch-like wearable sensor

Intervention Type DEVICE

Sleep Monitor

Remote Sensor

Intervention Type DEVICE

Polysomnography

Sleep Monitor

Intervention Type DEVICE

Videography

Thermal Camera

Intervention Type DEVICE

Other Intervention Names

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GENEActiv Watch EarlySense

Eligibility Criteria

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Inclusion Criteria

1. Male or female subjects aged ≥2 years of age and \<12 years of age at Day 1.
2. Written informed consent from parent(s)/guardian(s) and assent from the subject (where assent is applicable).
3. Native English speakers or demonstrated fluency in English (both subject and parent(s)/guardian(s)).
4. Has a clinical diagnosis of Atopic Dermatitis (AD) according to the criteria of Hanifin and Rajka (concomitant AD treatments are permitted on study).

Exclusion Criteria

1. AD affected surface areas are in a location of device placement.
2. Has unstable AD (Total BSA\>40%).
3. Has any planned surgical or medical procedure that would overlap with study participation.
Minimum Eligible Age

2 Years

Maximum Eligible Age

11 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kevin C Thomas, PhD MBA

Role: PRINCIPAL_INVESTIGATOR

Boston University, Department of Anatomy and Neurobiology

Locations

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Evans Biomedical Research Center

Boston, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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H-37801

Identifier Type: -

Identifier Source: org_study_id