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Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG

NCT ID: NCT03871647

Last Updated: 2021-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

256 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-11

Study Completion Date

2021-03-07

Brief Summary

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Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate.

Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.

Detailed Description

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Conditions

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Coronary Bypass Graft Surgery Atrial Fibrillation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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POAF group

Patients who will experience AF at any time during the first six days after the operation.

Beta blocker

Intervention Type DRUG

perioperative beta blockers

Non POAF group

Patients with a sinus rhythm during the first six days after the operation.

Beta blocker

Intervention Type DRUG

perioperative beta blockers

Interventions

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Beta blocker

perioperative beta blockers

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Age above 18 years.
2. Candidates for CABG surgery without a concurrent valve surgery.
3. Patients receiving perioperative beta blockers before new onset of postoperative AF.

Exclusion Criteria

1. Patients who have either persistent or permanent AF, atrial flutter or atrial tachycardia on ECG obtained on the day of the operation.
2. Serum creatinine \>2 mg/dL before the surgery.
3. Uncontrolled thyroid disease.
4. Recent treatment with amiodarone before the occurrence of POAF
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Misr International University

OTHER

Sponsor Role collaborator

Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Dina Mohamed Kamal El gindy

Assistant Lecturer of Clinical Pharmacy

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dina M El Gindy, MSC

Role: PRINCIPAL_INVESTIGATOR

Misr Ineternational University

Lamiaa M ElWakeel, PhD

Role: STUDY_CHAIR

Ain Shams University

Mona F Schaalan, PhD

Role: STUDY_DIRECTOR

Misr International University

Ramy MR Khorshid, Md, PhD

Role: STUDY_DIRECTOR

Ain Shams Uiversity

Mohamed H Solayman, PhD

Role: STUDY_DIRECTOR

Ain Sham University

Locations

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The Cardiovascular & Thoracic Academy - Ain Shams University.

Cairo, , Egypt

Site Status

Countries

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Egypt

References

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El Gindy DMK, Solayman MH, Khorshid R, Schaalan MF, El Wakeel LM. Effect of Clinical and Genetic Factors on the Development of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG) in Egyptian Patients Receiving Beta-Blockers. Cardiovasc Drugs Ther. 2024 Feb;38(1):99-108. doi: 10.1007/s10557-022-07380-6. Epub 2022 Sep 15.

Reference Type DERIVED
PMID: 36107363 (View on PubMed)

Other Identifiers

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PhD 53

Identifier Type: -

Identifier Source: org_study_id