Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

NCT ID: NCT03860883

Last Updated: 2024-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

2998 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-12-17

Study Completion Date

2034-12-31

Brief Summary

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Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of life.

Detailed Description

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This study will determine whether there is a difference in disease-free survival rates for patients with primary cutaneous melanoma with Breslow thickness \> 2mm or 1-2mm with ulceration (pT2b-pT4b, AJCC 8th edition), treated with either a 1cm excision margin or 2cm margin. The study is designed to be able to prove or disprove that there is no difference in risk of the tumour recurring around the scar or anywhere else in the body between the two groups of patients. If the study shows no risk of tumour recurrence then we will also be able to determine how much of an impact the narrower excision has on patients in terms of improved quality of life and reduced side effects from the surgery and melanoma disease. This trial will also evaluate and determine the economic impact of narrower excision margins on the health services and society in general.

Conditions

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Cutaneous Melanoma, Stage II

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm A (Wide Local Excision = 1cm Margin)

1cm Wide Local Excision margin + Sentinel Lymph Node Biopsy +/- Reconstruction

Group Type EXPERIMENTAL

Wide Local Excision = 1cm Margin

Intervention Type PROCEDURE

A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

Arm B (Wide Local Excision = 2cm Margin)

2 cm Wide Local Excision margin + Sentinel Lymph Node Biopsy +/- Reconstruction

Group Type ACTIVE_COMPARATOR

Wide Local Excision = 2cm Margin

Intervention Type PROCEDURE

A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

Interventions

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Wide Local Excision = 1cm Margin

A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

Intervention Type PROCEDURE

Wide Local Excision = 2cm Margin

A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Patients may be included in the study if they meet ALL of the following criteria:

1. 1\. Patients must have a Stage II primary invasive cutaneous melanoma (pT2b-pT4b, AJCC 8th edition) with Breslow thickness \>1.0mm to 2.0mm; \>2.0mm to 4.0mm or \>4.0mm with ulceration, or \>2.0mm to 4.0mm; or \>4.0mm without ulceration (Table 1) as determined by diagnostic biopsy (narrow excision, incision, shave or punch biopsy) and subsequent histopathological analysis.
2. Must have a primary melanoma that is cutaneous (including head, neck, trunk, extremity, scalp, palm or sole).
3. An uninterrupted 2cm margin must be technically feasible around biopsy scar or primary melanoma.
4. 4\. Surgical intervention (which refers to the staging -SLNB and WLE as these are both to be done on the same day) must be completed within 120 days of the original diagnosis. Surgical intervention must also be performed within 28 days of randomisation.
5. Patients must be 18 years or older at time of consent.
6. Patient must be able to give informed consent and comply with the treatment protocol and follow up plan.
7. Life expectancy of at least 5 years from the time of diagnosis, not considering the melanoma in question, as determined by the PI.
8. Patients must have an ECOG performance score between 0 and 1 at screening.
9. A survivor of prior cancer is eligible provided that ALL of the following criteria are met and documented:

* The patient has undergone potentially curative therapy for all prior malignancies,
* There has been no evidence of recurrence of any prior malignancies for at least FIVE years (with the exception of successfully treated uterine/cervical or non-melanoma skin cancers (SCCs/BCCs) with no evidence of recurrence), and
* The patient is deemed by their treating physician to be at low risk of recurrence from previous malignancies.

Exclusion Criteria

Patients will be excluded from the study for ANY of the following reasons:

1. Uncertain diagnosis of melanoma i.e., so-called 'melanocytic lesion of unknown malignant potential'.
2. Patient has already undergone WLE at the site of the primary index lesion.
3. Patient unable or ineligible to undergo staging SLNB of the primary index lesion.
4. Perineural invasion or neurotropic melanoma: Neurotropism or perineural invasion in any type of melanoma is an exclusion. Perineural invasion does not include entrapment of nerves within the main primary tumour mass.
5. Desmoplastic melanoma: with any patient where pathology determines melanoma as PURE desmoplastic (as per WHO definition of \>90% desmoplasia), they are not eligible for this study. However melanomas with less than 90% desmoplasia or mixed desmoplastic subtypes are eligible unless there is neurotropism present (perineural invasion).
6. Microsatellitosis (a nest of metastatic tumour cells found to be growing away from the primary tumour) as per AJCC 8th edition definition is an exclusion.
7. Subungual melanoma
8. Patient has already undergone a local flap reconstruction of the defect after excision of the primary and determination of an accurate excision margin is impossible.
9. History of previous or concurrent (i.e. \>1 primary melanoma) invasive melanoma.
10. Melanoma located distal to the metacarpophalangeal joint; on the tip of the nose; the eyelids or on the ear; genitalia, perineum or anus; mucous membranes or internal viscera.
11. Physical, clinical, radiographic or pathologic evidence of satellite, in-transit, regional, or distant metastatic melanoma.
12. Patient has undergone surgery on a separate occasion to clear the lymph nodes of the probable draining lymphatic field, including -SLNB, of the index melanoma.
13. Any additional solid tumour or hematologic malignancy during the past 5 years (with exception of non- melanoma skin cancers (T1 skin lesions of squamous cell carcinoma (SCCs), basal cell carcinoma (BCCs)), or uterine/cervical cancer).
14. Melanoma-related operative procedures not corresponding to criteria described in the protocol.
15. Planned adjuvant radiotherapy to the primary melanoma site after wide local excision is not permitted as part of the protocol and any patients given this treatment would be excluded from the study.
16. History of organ transplantation.
17. Oral or parenteral immunosuppressive agents (not topical or inhaled steroids) at enrolment or within 6 months prior to enrolment.

Pregnancy is not a specific exclusion criterion for this trial, though it may not be clinically appropriate to perform a wide excision and SLNB until the pregnancy has been completed, which may exclude the patient due to violation of inclusion criterion 4. We would advise careful counselling of the patient prior to enrolling the patient, which would include a discussion at the treating centre's multidisciplinary team meeting or tumour board. We would strongly advise contacting the central trial office to discuss the case prior to enrolling on the study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Norfolk and Norwich University Hospitals NHS Foundation Trust

OTHER

Sponsor Role collaborator

Canadian Cancer Trials Group

NETWORK

Sponsor Role collaborator

Cancer Trials Ireland

NETWORK

Sponsor Role collaborator

Zuyderland Medical Centre

OTHER

Sponsor Role collaborator

Melanoma and Skin Cancer Trials Limited

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Henderson

Role: STUDY_CHAIR

Peter MacCallum Cancer Centre, Australia

Marc Moncrieff

Role: STUDY_CHAIR

Norfolk & Norwich University Hospital

Locations

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University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, United States

Site Status RECRUITING

Banner MD Anderson Cancer Center

Gilbert, Arizona, United States

Site Status RECRUITING

Mayo Clinic Phoenix

Phoenix, Arizona, United States

Site Status RECRUITING

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Site Status RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, United States

Site Status RECRUITING

Los Angeles General Medical Center

Los Angeles, California, United States

Site Status RECRUITING

Los Angeles General Medical Center

Los Angeles, California, United States

Site Status RECRUITING

USC Norris Comprehensive Cancer Center

Los Angeles, California, United States

Site Status RECRUITING

USC Norris Comprehensive Cancer Center

Los Angeles, California, United States

Site Status RECRUITING

The Angeles (Cedars-Sinai Medical Center and its Affiliates)

Los Angeles, California, United States

Site Status RECRUITING

UC Irvine Health - Chao Family Comprehensive Cancer Center

Orange, California, United States

Site Status RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Orange, California, United States

Site Status RECRUITING

Stanford Cancer Institute

Palo Alto, California, United States

Site Status RECRUITING

Huntington Memorial Hospital

Pasadena, California, United States

Site Status RECRUITING

Stanford Cancer Center South Bay

San Jose, California, United States

Site Status RECRUITING

Kaiser Permanente - Vallejo Medical Center

Vallejo, California, United States

Site Status RECRUITING

Kaiser Permanente - Walnut Creek Medical Center

Walnut Creek, California, United States

Site Status RECRUITING

Smilow Hospital Care Center, Guilford

Guilford, Connecticut, United States

Site Status RECRUITING

Yale University

New Haven, Connecticut, United States

Site Status RECRUITING

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, United States

Site Status RECRUITING

MedStar Washington Hospital Center

Washington D.C., District of Columbia, United States

Site Status RECRUITING

University of Miami Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, United States

Site Status RECRUITING

University of Miami Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, United States

Site Status RECRUITING

University of Miami Sylvester Cancer Center at Coral Springs

Coral Springs, Florida, United States

Site Status RECRUITING

University of Miami Sylvester Comprehensive Center at Deerfield Beach

Deerfield Beach, Florida, United States

Site Status RECRUITING

University of Miami Sylvester Comprehensive Center at Hollywood

Hollywood, Florida, United States

Site Status RECRUITING

Baptist MD Anderson Cancer Center

Jacksonville, Florida, United States

Site Status RECRUITING

Mayo Clinic in Florida

Jacksonville, Florida, United States

Site Status RECRUITING

Lakeland Regional Health Hollis Cancer Center

Lakeland, Florida, United States

Site Status RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Centre

Miami, Florida, United States

Site Status RECRUITING

University of Miami Comprehensive Cancer Center at Kendall

Miami, Florida, United States

Site Status RECRUITING

University of Miami Comprehensive Cancer Center at Plantation

Plantation, Florida, United States

Site Status RECRUITING

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, United States

Site Status RECRUITING

Moffitt Cancer Center, Magnolia Campus

Tampa, Florida, United States

Site Status RECRUITING

Emory University Hospital Midtown

Atlanta, Georgia, United States

Site Status RECRUITING

Emory University

Atlanta, Georgia, United States

Site Status RECRUITING

Emory Saint Joseph's Hospital

Atlanta, Georgia, United States

Site Status RECRUITING

Northside Hospital Atlanta

Atlanta, Georgia, United States

Site Status RECRUITING

Northside Hospital Cancer Institute

Atlanta, Georgia, United States

Site Status NOT_YET_RECRUITING

Nancy N and JC Lewis Cancer & Research Pavilion St. Joseph's/Candler

Savannah, Georgia, United States

Site Status RECRUITING

Advocate Illinois Masonic Medical Center

Chicago, Illinois, United States

Site Status RECRUITING

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, United States

Site Status RECRUITING

Northwestern University

Evanston, Illinois, United States

Site Status RECRUITING

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, United States

Site Status RECRUITING

Northwestern Medicine Cancer Center Lake Forest Hospital

Lake Forest, Illinois, United States

Site Status RECRUITING

Advocate Lutheran General Hospital

Park Ridge, Illinois, United States

Site Status RECRUITING

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, United States

Site Status RECRUITING

Indiana University - Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, United States

Site Status RECRUITING

Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Indianapolis, Indiana, United States

Site Status RECRUITING

Franciscan Health Indianapolis

Indianapolis, Indiana, United States

Site Status RECRUITING

University of Kansas Hospital - Indian Creek Campus

Overland Park, Kansas, United States

Site Status RECRUITING

University of Kansas Hospital- Westwood Cancer Center

Westwood, Kansas, United States

Site Status RECRUITING

University of Kentucky

Lexington, Kentucky, United States

Site Status RECRUITING

MedStar Franklin Square Medical Center

Baltimore, Maryland, United States

Site Status RECRUITING

University of Michigan Medical Center

Ann Arbor, Michigan, United States

Site Status RECRUITING

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, United States

Site Status RECRUITING

Mercy Health Saint Mary's

Grand Rapids, Michigan, United States

Site Status RECRUITING

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, United States

Site Status RECRUITING

West Michigan Cancer Centre

Kalamazoo, Michigan, United States

Site Status RECRUITING

Siteman Cancer Centre, Barnes Jewish West County

Creve Coeur, Missouri, United States

Site Status RECRUITING

University of Kansas Cancer Center

Kansas City, Missouri, United States

Site Status RECRUITING

Cox South Hospital

Springfield, Missouri, United States

Site Status RECRUITING

Washington University School of Medicine

St Louis, Missouri, United States

Site Status RECRUITING

Nebraska Medicine - Bellevue

Bellevue, Nebraska, United States

Site Status RECRUITING

Nebraska Medicine-Village Pointe

Omaha, Nebraska, United States

Site Status RECRUITING

University of Nebraska Medicine

Omaha, Nebraska, United States

Site Status RECRUITING

Cooperman Barnabas Medical Center

Livingston, New Jersey, United States

Site Status RECRUITING

Rutgers Cancer Institute of New Jersey

Piscataway, New Jersey, United States

Site Status RECRUITING

Lovelace Medical Centre-Saint Joseph Square

Albuquerque, New Mexico, United States

Site Status RECRUITING

Lovelace Women's Hospital

Albuquerque, New Mexico, United States

Site Status RECRUITING

Northwell Health Imbert Cancer Center

Bay Shore, New York, United States

Site Status RECRUITING

Roswell Park Cancer Institute

Buffalo, New York, United States

Site Status RECRUITING

Northwell Health/Center for Advanced Medicine

Lake Success, New York, United States

Site Status RECRUITING

NYU Langone Medical Center (Winthrop Hospital)

Mineola, New York, United States

Site Status RECRUITING

Northern Westchester Hospital

Mount Kisco, New York, United States

Site Status RECRUITING

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

New York, New York, United States

Site Status RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, United States

Site Status RECRUITING

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Site Status RECRUITING

Vassar Brothers Medical Center

Poughkeepsie, New York, United States

Site Status RECRUITING

University of Rochester

Rochester, New York, United States

Site Status RECRUITING

Phelps Memorial Hospital Center

Sleepy Hollow, New York, United States

Site Status RECRUITING

State University of New York Upstate Medical University

Syracuse, New York, United States

Site Status RECRUITING

State University of New York Upstate Medical Center-Community Campus

Syracuse, New York, United States

Site Status RECRUITING

Wilmont Cancer Institute at Webster

Webster, New York, United States

Site Status RECRUITING

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Site Status RECRUITING

Duke University Medical Center

Durham, North Carolina, United States

Site Status RECRUITING

East Carolina University

Greenville, North Carolina, United States

Site Status RECRUITING

University of North Carolina Hospitals - Hillsborough Campus

Hillsborough, North Carolina, United States

Site Status RECRUITING

Sanford Broadway Medical Centre

Fargo, North Dakota, United States

Site Status RECRUITING

Sanford Roger Maris Cancer Centre

Fargo, North Dakota, United States

Site Status RECRUITING

University Hospitals Avon Health Center

Avon, Ohio, United States

Site Status RECRUITING

Miami Valley Hospital South

Centerville, Ohio, United States

Site Status RECRUITING

University Hospitals Geauga Medical Center

Chardon, Ohio, United States

Site Status RECRUITING

University of Cincinnati

Cincinnati, Ohio, United States

Site Status RECRUITING

University Hospitals Cleveland Medical Centre

Cleveland, Ohio, United States

Site Status RECRUITING

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Site Status RECRUITING

University Hospitals Chagrin Highlands Medical Centre

Orange, Ohio, United States

Site Status RECRUITING

West Chester Hospital (OH394)

West Chester, Ohio, United States

Site Status RECRUITING

University Hospitals St. John Medical Center

Westlake, Ohio, United States

Site Status RECRUITING

OUHSC Stephenson Cancer Center

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Mercy Health Center - Oncology Hematology

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Kaiser Sunnyside Medical Center

Clackamas, Oregon, United States

Site Status RECRUITING

Kaiser Permanente Northwest - Oncology Clinic

Portland, Oregon, United States

Site Status RECRUITING

St. Luke's University Health Network - Allentown Cancer Center

Allentown, Pennsylvania, United States

Site Status RECRUITING

St Luke's University Health Network, Bethlehem Campus

Bethlehem, Pennsylvania, United States

Site Status RECRUITING

St Luke's University Health Network, Anderson Campus

Easton, Pennsylvania, United States

Site Status RECRUITING

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

St Luke's University Health Network Quakertown Campus

Quakertown, Pennsylvania, United States

Site Status RECRUITING

St. Luke's University Health Network - Upper Bucks

Quakertown, Pennsylvania, United States

Site Status RECRUITING

Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, United States

Site Status RECRUITING

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status RECRUITING

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, United States

Site Status RECRUITING

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States

Site Status RECRUITING

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States

Site Status RECRUITING

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Site Status RECRUITING

Intermountain Medical Center

Murray, Utah, United States

Site Status RECRUITING

Huntsman Cancer Institute (The University of Utah)

Salt Lake City, Utah, United States

Site Status RECRUITING

University of Vermont Medical Center

Burlington, Vermont, United States

Site Status RECRUITING

University of Vermount and Sate Agricultural College

Burlington, Vermont, United States

Site Status RECRUITING

University of Virginia Health System

Charlottesville, Virginia, United States

Site Status RECRUITING

VCU Massey Cancer Center Peninsula Cancer Institute

Newport News, Virginia, United States

Site Status RECRUITING

VCU Massey Cancer Center

Richmond, Virginia, United States

Site Status RECRUITING

Carilion Roanoke Memorial Hospital

Roanoke, Virginia, United States

Site Status RECRUITING

VCU Massey Cancer Center Affiliate Valley Health

Winchester, Virginia, United States

Site Status RECRUITING

University of Winsconsin Carbone Cancer Center-Eastpark medical Center

Madison, Wisconsin, United States

Site Status RECRUITING

University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, United States

Site Status RECRUITING

Marshfield Medical Center - Marshfield

Marshfield, Wisconsin, United States

Site Status RECRUITING

Aurora St Luke's Medical Center

Milwaukee, Wisconsin, United States

Site Status RECRUITING

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status RECRUITING

Marshfield Medical Center- Weston

Weston, Wisconsin, United States

Site Status RECRUITING

Calvary Public Hospital Bruce

Bruce, Australian Capital Territory, Australia

Site Status RECRUITING

The Canberra Hospital

Garran, Australian Capital Territory, Australia

Site Status NOT_YET_RECRUITING

Westmead Hospital

Sydney, New South Wales, Australia

Site Status RECRUITING

Melanoma Institute Australia

Sydney, New South Wales, Australia

Site Status RECRUITING

Royal Prince Alfred Hospital

Sydney, New South Wales, Australia

Site Status RECRUITING

Princess Alexandra Hospital

Brisbane, Queensland, Australia

Site Status NOT_YET_RECRUITING

Robina Hospital

Gold Coast, Queensland, Australia

Site Status NOT_YET_RECRUITING

Royal Adelaide Hospital

Adelaide, South Australia, Australia

Site Status RECRUITING

Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia

Site Status RECRUITING

The Alfred Hospital

Melbourne, Victoria, Australia

Site Status RECRUITING

Tom Baker Cancer Centre

Calgary, Alberta, Canada

Site Status RECRUITING

BCCA - Cancer Centre for the Southern Interior

Kelowna, British Columbia, Canada

Site Status RECRUITING

CancerCare Manitoba

Winnipeg, Manitoba, Canada

Site Status RECRUITING

Royal Victoria Regional Health Centre

Barrie, Ontario, Canada

Site Status RECRUITING

Hamilton Health Sciences Centre

Hamilton, Ontario, Canada

Site Status RECRUITING

Oak Valley Health

Markham, Ontario, Canada

Site Status RECRUITING

Ottawa Hospital Research Institute

Ottawa, Ontario, Canada

Site Status RECRUITING

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Site Status RECRUITING

UHN - Princess Margaret Cancer Centre

Toronto, Ontario, Canada

Site Status RECRUITING

Hopital Maisonneuve-Rosemont

Montreal, Quebec, Canada

Site Status RECRUITING

Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec, Canada

Site Status RECRUITING

Hotel-Dieu de Quebec

Québec, Quebec, Canada

Site Status RECRUITING

Cork University Hospital

Cork, , Ireland

Site Status RECRUITING

Mater Misericordiae University Hospital

Dublin, , Ireland

Site Status RECRUITING

St James Hospital

Dublin, , Ireland

Site Status RECRUITING

IOV Istituto Oncologico Veneto IRCCS-Padova

Padua, , Italy

Site Status NOT_YET_RECRUITING

Fondazione IRCCS Policlinico San Matteo

Pavia, , Italy

Site Status NOT_YET_RECRUITING

AOU Città della Salute e della Scienza di Torino

Torino, , Italy

Site Status NOT_YET_RECRUITING

Flevo Hospital

Almere Stad, Flevoland, Netherlands

Site Status RECRUITING

Ziekenhuis Gelderse Vallei

Ede, Gelderland, Netherlands

Site Status RECRUITING

Gelre Hospital

Zutphen, Gelderland, Netherlands

Site Status RECRUITING

Maxima Medical Centre, Eindhoven

Eindhoven, North Brabant, Netherlands

Site Status RECRUITING

University Medical Centre Groningen

Groningen, , Netherlands

Site Status RECRUITING

Zuyderland Medical Center

Heerlen, , Netherlands

Site Status RECRUITING

Maastricht University Medical Center

Maastricht, , Netherlands

Site Status RECRUITING

Diakonessenhuis

Utrecht, , Netherlands

Site Status RECRUITING

Maxima Medical Center - Veldhoven

Veldhoven, , Netherlands

Site Status RECRUITING

Isala Hospital

Zwolle, , Netherlands

Site Status RECRUITING

North Shore Hospital

Auckland, , New Zealand

Site Status RECRUITING

Institute of Oncology Ljubljana

Ljubljana, , Slovenia

Site Status RECRUITING

Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status RECRUITING

Central Hospital Kristianstad

Kristianstad, , Sweden

Site Status RECRUITING

University Hospitals Birmingham NHS Foundation Trust

Edgbaston, Birmingham, United Kingdom

Site Status RECRUITING

Royal Cornwall Hospital NHS Trust

Truro, Cornwall, United Kingdom

Site Status RECRUITING

Hull University Teaching Hospitals NHS Trust

Hull, East Yorkshire, United Kingdom

Site Status RECRUITING

MID & South Essex NHS Foundation Trust

Westcliff-on-Sea, Essex, United Kingdom

Site Status RECRUITING

Lancashire Teaching Hospitals NHS Foundation Trust

Preston, Lancashire, United Kingdom

Site Status RECRUITING

Oxford University Hospitals NHS Foundation Trust

Headington, Oxford, United Kingdom

Site Status RECRUITING

Imperial College Healthcare NHS Trust

London, The Bays, United Kingdom

Site Status RECRUITING

Queen Victoria Hospital NHS Foundation Trust

East Grinstead, West Sussex, United Kingdom

Site Status RECRUITING

North Bristol NHS Trust

Bristol, , United Kingdom

Site Status RECRUITING

Cambridge University Hospitals NHS Foundation Trust

Cambridge, , United Kingdom

Site Status RECRUITING

The Leeds Teaching Hospitals NHS Trust

Leeds, , United Kingdom

Site Status RECRUITING

St. Helens & Knowsley Teaching Hospitals NHS Trust

Liverpool, , United Kingdom

Site Status RECRUITING

Royal Free London NHS Foundation Trust

London, , United Kingdom

Site Status RECRUITING

Guy's and St Thomas's NHS Foundation Trust, of St Thomas' Hospital

London, , United Kingdom

Site Status RECRUITING

St George's University Hospitals NHS Foundation Trust

London, , United Kingdom

Site Status RECRUITING

The Royal Marsden Hospital NHS Foundation Trust

London, , United Kingdom

Site Status RECRUITING

The Christie NHS Foundation Trust

Manchester, , United Kingdom

Site Status RECRUITING

South Tees Hospitals NHS Foundation Trust of The James Cook University Hospital

Middlesbrough, , United Kingdom

Site Status RECRUITING

Norfolk and Norwich University Hospital NHS Trust

Norwich, , United Kingdom

Site Status RECRUITING

Nottingham University Hospitals, NHS Trust, Trust HQ, City Hospital

Nottingham, , United Kingdom

Site Status RECRUITING

Countries

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United States Australia Canada Ireland Italy Netherlands New Zealand Slovenia Sweden United Kingdom

Central Contacts

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Melanoma and Skin Cancer Trials Coordinator

Role: CONTACT

+61 3 9903 9022

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

John H Howard, MD

Role: primary

Tiffany Fulford

Role: backup

Mark Gimbel

Role: primary

Sandra Ortega

Role: backup

Barbara A Pockaj, MD

Role: primary

Courtney Nelson

Role: backup

Michail Mavros

Role: primary

Maki Yamamoto, MD

Role: primary

Gino In

Role: primary

Gino In, MD

Role: primary

Gino In

Role: primary

Gino In, MD

Role: primary

Dr Mark Faries

Role: primary

Jeremy Harris

Role: primary

Maki Yamamoto

Role: primary

Amanda Kirane, MD FACS

Role: primary

650-725-4169

Patrick Yuan

Role: backup

+1 650-498-7061

Mark Faries

Role: primary

Amanda Kirane

Role: primary

Tatjana Kolevska, MD

Role: primary

Desiree Goldstein

Role: backup

Tatjana Kolevska, MD

Role: primary

Desiree Goldstein

Role: backup

James Clune

Role: primary

James Clune

Role: primary

Geoffrey T Gibney

Role: primary

Marc Boisvert, MD

Role: primary

Nicolas Rojas

Role: backup

Jessica S Crystal

Role: primary

Jessica S Crystal

Role: primary

Jessica S Crystal

Role: primary

Jessica S Crystal

Role: primary

Jessica S Crystal

Role: primary

Konstantinos Chouliaras

Role: primary

James W Jakub

Role: primary

Manuel Molina

Role: primary

Jessica S Crystal

Role: primary

Jessica S Crystal

Role: primary

Jessica S Crystal

Role: primary

Jonathan Zager

Role: primary

Jonathan Zager

Role: primary

Michael Lowe, MD

Role: primary

Rachel Mock

Role: backup

Dr Michael Lowe

Role: primary

Michael Lowe, MD

Role: primary

Charisse Ellis

Role: backup

Nicole Kounalakis

Role: primary

Margaret Ferreira

Role: primary

Dr. Nicole Kounalakis

Role: backup

Yana Puckett, MD

Role: primary

Stephanie Reyes

Role: backup

Sigrun Hallmeyer

Role: primary

Jeffrey Wayne

Role: primary

Jeffrey Wayne

Role: primary

Jeffrey Wayne

Role: primary

Jeffrey Wayne

Role: primary

Sigrun Hallmeyer, MD

Role: primary

Cheryl Korabik

Role: backup

Jeffrey Wayne

Role: primary

Karl Bilimoria, MD

Role: primary

Role: backup

Karl Bilimoria

Role: primary

Juliana Meyer

Role: primary

Luke Selby

Role: primary

Luke Selby

Role: primary

Erin Burke

Role: primary

Edward McCarron

Role: primary

Christina Angeles

Role: primary

Christina Angeles

Role: primary

Kathleen Yost

Role: primary

Renee Porter

Role: backup

Kathleen Yost

Role: primary

Kathleen Yost

Role: primary

Ryan Fields

Role: primary

Luke Selby

Role: primary

Srikant Nannapaneni

Role: primary

Ryan Fields

Role: primary

Bradley Reames

Role: primary

Bradley Reames

Role: primary

Bradley Reames

Role: primary

Adam Berger

Role: primary

Professor Adam Berger

Role: primary

Bridget Fahy, MD

Role: primary

Bridget Fahy, MD

Role: primary

Alan Kadison, MD

Role: primary

Diane Delliliune

Role: backup

Shalana O'Brien

Role: primary

Alan Kadison, MD

Role: primary

Alexa Amoroso

Role: backup

Erica Friedman

Role: primary

Alan Kadison

Role: primary

Erica Friedman

Role: primary

Bret Taback

Role: primary

Associate Professor Danielle Bello

Role: primary

James Nitzkorski

Role: primary

Karley Flinn

Role: backup

Paul Barr

Role: primary

Alan Kadison

Role: primary

Daniel Thomas, MD

Role: primary

Laine Abernathy

Role: backup

Daniel Thomas, MD

Role: primary

Laine Abernathy

Role: backup

Paul Barr, MD

Role: primary

Sarah Cawley

Role: backup

David W Ollila

Role: primary

Jay Lee

Role: primary

Nasreen Vohra

Role: primary

David Ollila

Role: primary

Preston Steen

Role: primary

Preston Steen

Role: primary

Luke Rothermel

Role: primary

James Ouellette

Role: primary

Luke Rothermel

Role: primary

Jeffrey Sussman

Role: primary

Luke Rothermel

Role: primary

Joal Joal

Role: primary

Luke Rothermel

Role: primary

Jeffrey Sussman

Role: primary

Luke Rothermel

Role: primary

William Dooley

Role: primary

Christian Ellis, DO

Role: primary

Trisha Strubhar

Role: backup

Sandeep Mashru

Role: primary

Sandeep Mashru

Role: primary

Darius Desai, MD

Role: primary

Amy Grossman

Role: backup

Darius Desai

Role: primary

Darius Desai

Role: primary

Dr Stephanie Greco

Role: primary

Darius Desai

Role: primary

Darius Desai, MD

Role: primary

Amy Grossman

Role: backup

David Bertsch, MD

Role: primary

Susan Hadlock

Role: backup

Andrea Abbott

Role: primary

Daniel Almquist, MD

Role: primary

Daniel Almquist, MD

Role: primary

Jeffrey Gershenwald

Role: primary

Fedrico Tozzi, MD

Role: primary

Samantha Bankston

Role: backup

Tawnya Bowles

Role: primary

Kevin Adams

Role: backup

Professor John Hynstrom

Role: primary

Jessica Cintolo-Gonzalez, MD

Role: primary

Elizabeth Abrecht

Role: backup

Jessica Cintolo-Gonzalez, MD

Role: primary

Elizabeth Abrecht

Role: backup

Lynn Dengel

Role: primary

Giao Phan

Role: primary

Giao Phan

Role: primary

Giao Phan

Role: primary

Kristin Campbell

Role: backup

Giao Phan

Role: primary

Heather Neuman

Role: primary

Heather Neuman, MD

Role: backup

Heather Neuman

Role: primary

Sam Hanson

Role: backup

Rohit Sharma

Role: primary

Sigrun Hallmeyer

Role: primary

Jennifer Bruening

Role: primary

Chloe Papageorgio

Role: backup

Rohit Sharma, MD

Role: primary

Dr Rebecca Read

Role: primary

Emily Baxter

Role: primary

Pablo Fernandez-Peñas

Role: primary

Andrew Spillane

Role: primary

Robyn Saw

Role: primary

Prof Mark Smithers

Role: primary

Dr Jennifer Chang

Role: primary

Robert Whitfield

Role: primary

Michael Henderson

Role: primary

Dr Frank Bruscino-Raiola

Role: primary

Christopher Baliski

Role: primary

Justin Rivard, Dr

Role: primary

204-787-4156

Kelly Cruise

Role: primary

705-728-9090 ext. 45639

Dr. Renee Hanrahan

Role: backup

Dr. Valerie Francescutti

Role: primary

905-387-9495

Jennifer Zhirui Li

Role: primary

Dr. Carolyn Nessim

Role: primary

Dr Frances Wright

Role: primary

416-480-4210

Alexandra Easson, Dr

Role: primary

Audrey Lamoureux

Role: primary

514-252-3400 ext. 6258

Leïla Idrissi Kaïtouni

Role: backup

514-252-3400 ext. 5853

Kerianne Boulva

Role: primary

Dr Cindy Boulanger-Gobeil

Role: primary

Prof Jim Clover, BMEd Sci,BM BS,MRCS,MD,FFERCS

Role: primary

0214922575

Shirley Potter

Role: primary

Marlese Dempsey

Role: primary

Romina Spina

Role: primary

Alessandra Ferrari

Role: primary

Valentina Pala

Role: primary

Gwen Diepenhorst

Role: primary

Role: backup

Miriam L Hoven-Gondrie

Role: primary

Dominique van Uden, MD

Role: primary

Sabrina Maaskant

Role: primary

Barbara Leeuwen

Role: primary

James van Bastelaar, Dr

Role: primary

Kevin Wevers

Role: primary

Barbara Molenkamp

Role: primary

Sabrina Maaskant

Role: primary

Anne-Brecht Francken

Role: primary

Dr Richard Martin

Role: primary

Barbara Peric, MD, PhD

Role: primary

Roger Olofsson Bagge

Role: primary

(0)31-3428207 ext. +46

Dr Karolin Isaksson

Role: primary

Agustin Martin-Clavijo

Role: primary

Polly King

Role: primary

Paolo Matteucci

Role: primary

Prof Peter Dziewulski

Role: primary

Richard Wain

Role: primary

oliver cassell

Role: primary

Role: backup

Jonathon Dunne

Role: primary

Mark Cabelles

Role: backup

Siva Kumar

Role: primary

Ewan Wilson, Mr

Role: primary

Amit Roshan

Role: primary

Howard Peach, Mr

Role: primary

Rowan Pritchard Jones, Prof

Role: primary

Steven Hamilton

Role: primary

Jenny Geh, Ms

Role: primary

Joy Odili, Ms

Role: primary

Myles Smith

Role: primary

Role: backup

Deemesh Oudit

Role: primary

Oliver Bassett, Mr

Role: primary

Professor Marc Moncrieff

Role: primary

Mr Jonathon Pollock

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

02.18

Identifier Type: -

Identifier Source: org_study_id

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