Safety, Tolerability, Pharmacokinetics, and Food Effect of BLU-782 in Healthy Adults
NCT ID: NCT03858075
Last Updated: 2019-11-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
108 participants
INTERVENTIONAL
2019-02-12
2019-09-11
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SEQUENTIAL
BASIC_SCIENCE
QUADRUPLE
Study Groups
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Single ascending doses with BLU-782
BLU-782
oral capsules
Single ascending doses with placebo
Placebo
oral capsules
Multiple ascending doses with BLU-782
BLU-782
oral capsules
Multiple ascending doses with placebo
Placebo
oral capsules
Food effect of BLU-782 taken with food
BLU-782 taken with food
oral capsules
Food effect of BLU-782 taken without food
BLU-782
oral capsules
Interventions
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BLU-782
oral capsules
Placebo
oral capsules
BLU-782 taken with food
oral capsules
Eligibility Criteria
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Inclusion Criteria
* Non-smoker
* Body mass index (BMI) ≥ 18 and ≤ 32 kg/m2
* No clinically significant cardiac history
* No current electrocardiogram (ECG) abnormality
* Female must not be of childbearing potential
Exclusion Criteria
* History or current clinically significant medical/psychiatric condition/disease
* History of any illness that, in the opinion of the Investigator, might impact the results of the study or pose an additional risk to the participant
* History or current alcoholism/drug abuse
* History or current allergy to the study drug or a similar drug
19 Years
65 Years
ALL
Yes
Sponsors
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Blueprint Medicines Corporation
INDUSTRY
Responsible Party
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Locations
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Undisclosed
Lincoln, Nebraska, United States
Countries
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Other Identifiers
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BLU-782-0101
Identifier Type: -
Identifier Source: org_study_id
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