Trial Outcomes & Findings for A Message Framing Intervention for Increasing Parental Acceptance of Human Papillomavirus Vaccination (NCT NCT03856437)
NCT ID: NCT03856437
Last Updated: 2024-03-15
Results Overview
Attitudes toward HPV vaccination for children Scale range: 1-7 (higher score indicates more positive attitude) Subscales were averaged.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
1170 participants
Primary outcome timeframe
baseline posttest (test was approximately 5 minutes to complete)
Results posted on
2024-03-15
Participant Flow
Participant milestones
| Measure |
Gain-framed Messages
Participants in this arm receive gain-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Loss-framed Messages
Participants in this arm receive loss-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Control Messages
Participants in this arm receive non-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
|---|---|---|---|
|
Overall Study
STARTED
|
380
|
407
|
383
|
|
Overall Study
COMPLETED
|
380
|
407
|
383
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
A Message Framing Intervention for Increasing Parental Acceptance of Human Papillomavirus Vaccination
Baseline characteristics by cohort
| Measure |
Gain-framed Messages
n=380 Participants
Participants in this arm receive gain-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Loss-framed Messages
n=407 Participants
Participants in this arm receive loss-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Control Messages
n=383 Participants
Participants in this arm receive non-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Total
n=1170 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Continuous
|
38.10 years
STANDARD_DEVIATION 8.59 • n=5 Participants
|
38.64 years
STANDARD_DEVIATION 8.86 • n=7 Participants
|
38.05 years
STANDARD_DEVIATION 8.81 • n=5 Participants
|
38.27 years
STANDARD_DEVIATION 8.75 • n=4 Participants
|
|
Sex/Gender, Customized
Male
|
103 Participants
n=5 Participants
|
99 Participants
n=7 Participants
|
111 Participants
n=5 Participants
|
313 Participants
n=4 Participants
|
|
Sex/Gender, Customized
Female
|
272 Participants
n=5 Participants
|
299 Participants
n=7 Participants
|
262 Participants
n=5 Participants
|
833 Participants
n=4 Participants
|
|
Sex/Gender, Customized
Non-Binary
|
3 Participants
n=5 Participants
|
5 Participants
n=7 Participants
|
5 Participants
n=5 Participants
|
13 Participants
n=4 Participants
|
|
Sex/Gender, Customized
Other
|
2 Participants
n=5 Participants
|
4 Participants
n=7 Participants
|
5 Participants
n=5 Participants
|
11 Participants
n=4 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Asian
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Black or African American
|
380 Participants
n=5 Participants
|
407 Participants
n=7 Participants
|
383 Participants
n=5 Participants
|
1170 Participants
n=4 Participants
|
|
Race (NIH/OMB)
White
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
|
Baseline Attitudes
|
5.35 units on a scale
STANDARD_DEVIATION 1.77 • n=5 Participants
|
5.30 units on a scale
STANDARD_DEVIATION 1.93 • n=7 Participants
|
5.37 units on a scale
STANDARD_DEVIATION 1.87 • n=5 Participants
|
5.34 units on a scale
STANDARD_DEVIATION 1.86 • n=4 Participants
|
PRIMARY outcome
Timeframe: baseline posttest (test was approximately 5 minutes to complete)Attitudes toward HPV vaccination for children Scale range: 1-7 (higher score indicates more positive attitude) Subscales were averaged.
Outcome measures
| Measure |
Gain-framed Messages
n=380 Participants
Participants in this arm receive gain-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Loss-framed Messages
n=407 Participants
Participants in this arm receive loss-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Control Messages
n=383 Participants
Participants in this arm receive non-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
|---|---|---|---|
|
Attitudes
|
5.61 score on a scale
Standard Deviation 1.74
|
5.56 score on a scale
Standard Deviation 1.94
|
5.51 score on a scale
Standard Deviation 1.87
|
PRIMARY outcome
Timeframe: baseline posttest (test was approximately 5 minutes to complete)Intention to have children vaccinated against HPV free of cost Scale range: 1-6 (higher score indicates stronger intention) Subscales were averaged.
Outcome measures
| Measure |
Gain-framed Messages
n=380 Participants
Participants in this arm receive gain-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Loss-framed Messages
n=407 Participants
Participants in this arm receive loss-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Control Messages
n=383 Participants
Participants in this arm receive non-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
|---|---|---|---|
|
Intention to Vaccinate Free of Cost
|
4.56 units on a scale
Standard Deviation 1.57
|
4.59 units on a scale
Standard Deviation 1.64
|
4.46 units on a scale
Standard Deviation 1.70
|
SECONDARY outcome
Timeframe: baseline posttest (test was approximately 5 minutes to complete)Intention to have children vaccinated against HPV free with cost Scale range: 1-6 (higher score indicates stronger intention) Subscales were averaged.
Outcome measures
| Measure |
Gain-framed Messages
n=380 Participants
Participants in this arm receive gain-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Loss-framed Messages
n=407 Participants
Participants in this arm receive loss-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
Control Messages
n=383 Participants
Participants in this arm receive non-framed HPV vaccination messages.
HPV vaccination messages: Digital multimedia messages consisting of text and imagery conveying the benefits of being vaccinated against HPV, the costs of not being vaccinated against HPV, or neither benefits or costs but simply a call for action.
|
|---|---|---|---|
|
Intention to Vaccinate With Cost
|
4.17 units on a scale
Standard Deviation 1.70
|
4.27 units on a scale
Standard Deviation 1.79
|
4.08 units on a scale
Standard Deviation 1.82
|
Adverse Events
Gain-framed Messages
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Loss-framed Messages
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Control Messages
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place