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Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment

NCT ID: NCT03855319

Last Updated: 2019-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-12-15

Study Completion Date

2018-12-15

Brief Summary

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This is a non-pharmacological pilot study showing the improvement of a SMR/theta neurofeedback training program on cognitive performance and EEG activity in Elderly with Mild Cognitive Impairment.

Detailed Description

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Neurofeedback training (NF) as self-regulation method of brain activity, may be beneficial in elderly with mild cognitive impairment. In this pilot study, the investigators studied whether a sensorimotor(SMR)/theta NF training could improve cognitive performance and brain electrical activity in a sample group of elderly patients with mild cognitive impairment. Twenty participants performed an electroencephalography recording, a battery of neuropsychological tests before the neurofeedback training program (T0), following the neurofeedback training program (T1) and 1-month follow-up (T2).

Conditions

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Mild Cognitive Impairment

Keywords

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Neurofeedback Electroencephalography MCI Alzheimer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

no randomized, no controlled
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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SMR neurofeedback training to MCI

A sensorimotor/theta neurofeedback training consisted of 20 individuals sessions, twice a week during 11 weeks maximum. For each subject, NF was planned and conducted by a neuropsychologist experienced in neurophysiology an neurofeedback. Each session lasted 1h10 minutes and was conducted as follows:

* Preparation and installation of the electrodes, verification of the impedance, adjustement of the calibration.
* NF training (tasks and video described below)(45minutes)
* Feedback and debriefing about the session (15 minutes)

Group Type EXPERIMENTAL

SMR neurofeedback training to MCI

Intervention Type BEHAVIORAL

The intervention consisted to increase the synaptic strengths and sensitivity within this network. Electroencephalography signals for SMR/theta training was recorded at channel Cz according to the international 10-20 system. Theta rhythm was also recorded and, in this case, SMR was stimulated while theta waves were suppressed.A 32 channels system (EEGDigitrcak Biofeedback plus module, Inc Elmiko Medical) was used for the SMR/theta Neurofeedback training.

Interventions

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SMR neurofeedback training to MCI

The intervention consisted to increase the synaptic strengths and sensitivity within this network. Electroencephalography signals for SMR/theta training was recorded at channel Cz according to the international 10-20 system. Theta rhythm was also recorded and, in this case, SMR was stimulated while theta waves were suppressed.A 32 channels system (EEGDigitrcak Biofeedback plus module, Inc Elmiko Medical) was used for the SMR/theta Neurofeedback training.

Intervention Type BEHAVIORAL

Other Intervention Names

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SMR neurofeedback

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Mild Cognitive Impairment
* education level of 9 years of studies minimum
* righthandedness
* subjective memory complaint confirmed by an informant
* a Mini Mental Status Examination score \>20.
* preserve activity of daily living and absence of dementia.

Exclusion Criteria

* elderly persons who were under guardianship
* resident in nursing facilities
* neurological disease, psychiatric disease
* and involved in another cogniitve intervention.
Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fabienne Marlats

OTHER

Sponsor Role lead

Responsible Party

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Fabienne Marlats

Neuropsychologist

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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anne-Sophie AR Rigaud, Professor

Role: PRINCIPAL_INVESTIGATOR

Study Principal Investigator

Other Identifiers

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LUS3EEGNF

Identifier Type: -

Identifier Source: org_study_id