Satisfaction With XEN Gel Stent Versus Trabeculectomy for the Treatment of Glaucoma

NCT ID: NCT03852810

Last Updated: 2021-10-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-25

Study Completion Date

2020-12-09

Brief Summary

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This is a prospective, observational, non-interventional study of patients scheduled to receive surgical intervention either via XEN or trabeculectomy for open-angle glaucoma. The decision to treat patients with a particular surgical procedure will not be influenced by the study as the treatment decision will continue to be made by the patient and the clinician. There will be no study mandated visits or treatments.

Detailed Description

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Conditions

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Glaucoma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Receiving surgical intervention via XEN Gel Stent (XEN)

Patient Reported Outcomes (PRO) will be collected before and after this particular procedure

No interventions assigned to this group

Receiving surgical intervention via trabeculectomy

Patient Reported Outcomes (PRO) will be collected before and after this particular procedure

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with OAG (Open Angle Glaucoma) and using at least 2 topical IOP-lowering medication classes in the study eye
* Scheduled to receive surgical treatment with either XEN (Xen gel stent) or trabeculectomy in the study eye
* Access to an electronic device with internet capabilities and an email address for completion of PROs (Patient Reported Outcomes)
* Be willing and able to complete PROs (Patient Reported Outcomes) at the specified time points
* Able to provide voluntary, informed consent to participate in this study

Exclusion Criteria

* Diagnosed with angle closure glaucoma in the study eye
* Presence of a secondary glaucoma, pseudoexfoliation glaucoma, or pigmentary glaucoma
* Presence of neovascular, uveitic, or angle recession glaucoma or any glaucoma associate with vascular disorders
* Prior incisional glaucoma surgery, canal-based surgery, suprachoroidal space-based surgery (trabeculectomy, viscocanalostomy, canaloplasty, shunts of any type, collagen implants, etc.) or a cilio-ablative procedure
* Clinically significant inflammation or infection in the study eye within 30 days prior to the baseline visit (e.g. blepharitis, conjunctivitis, keratitis, uveitis, herpes simplex infection)
* History of corneal surgery, corneal opacities, or corneal disease
* Prior intraocular surgery in either eye ≤ 3 months prior to study enrollment with the exception of uncomplicated cataract surgery in either eye ≥ 1 month prior to study enrollment
* Anticipated ocular surgery in either eye within 6 months of baseline
* Concomitant cataract surgery scheduled at the time of glaucoma procedure

The study eye is defined as the eye receiving surgical intervention with either XEN or trabeculectomy.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Allergan

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joanna Campbell, Ph.D

Role: STUDY_DIRECTOR

Allergan

Locations

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Dalhousie University

Halifax, Nova Scotia, Canada

Site Status

Galen Eye Center

Kingston, Ontario, Canada

Site Status

Prism Eye Institute

Mississauga, Ontario, Canada

Site Status

Toronto Ophthalmic Research Innovation Centre, Inc

Toronto, Ontario, Canada

Site Status

Universitat Augenklinik

Mainz, , Germany

Site Status

Ludwig-Maximilians-Universität München

Munich, , Germany

Site Status

University of Tübingen

Tübingen, , Germany

Site Status

Addenbrooke's Hospital

Cambridge, , United Kingdom

Site Status

Royal Surrey County Hospital

Guildford, , United Kingdom

Site Status

Southend University Hospital

Southend-on-Sea, , United Kingdom

Site Status

Countries

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Canada Germany United Kingdom

Related Links

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http://www.investigatordatabank.org/

To be considered as a site for current and future Allergan Clinical Trials, please register using the Investigator Databank link.

http://www.AllerganClinicalTrials.com

Additional information on study locations near you may be found at AllerganClinicalTrials.com. For any study not on AllerganClinicalTrials.com, please contact [email protected] for assistance

Other Identifiers

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P-2016-6380

Identifier Type: -

Identifier Source: org_study_id